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Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis

dc.contributor.authorCarini, Claudio
dc.contributor.authorHunter, Ewan
dc.contributor.authorRamadass, Aroul S.
dc.contributor.authorGreen, Jayne
dc.contributor.authorAkoulitchev, Alexandre
dc.contributor.authorMcInnes, Iain B.
dc.contributor.authorGoodyear, Carl S.
dc.contributor.authorLiversidge, Janet
dc.contributor.authorReid, David
dc.contributor.authorBasu, Neil
dc.date.accessioned2018-02-13T12:26:06Z
dc.date.available2018-02-13T12:26:06Z
dc.date.issued2018-01-29
dc.identifier.citationCarini , C , Hunter , E , Scottish Early Rheumatoid Arthritis Inception cohort Investigators , Ramadass , A S , Green , J , Akoulitchev , A , McInnes , I B & Goodyear , C S 2018 , ' Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis ' Journal of translational medicine , vol 16 , 18 , pp. 1-11 . DOI: 10.1186/s12967-018-1387-9en
dc.identifier.issn1479-5876
dc.identifier.otherPURE: 115923372
dc.identifier.otherPURE UUID: 5039f046-fa06-4324-a84d-4435d58e1896
dc.identifier.otherRIS: urn:55CD676F9684B92CC2C04CFB25F024A4
dc.identifier.otherRIS: Carini2018
dc.identifier.otherScopus: 85041231810
dc.identifier.urihttp://hdl.handle.net/2164/10036
dc.descriptionThe authors would like to thank members of OBD Reference Facility Benjamin Foulkes, Chloe Bird, Emily Corfeld and Matthew Salter for expedient processing of clinical samples on the EpiSwitch™ platform and Magdalena Jeznach and Willem Westra for help with preparation of the manuscript. The study employed samples from the SERA Biobank used with permission and approval of the SERA Approval Group. We gratefully acknowledge the invaluable contribution of the clinicians and operating team in SERA. We would also like to thank Prof. Raju Kucherlapati (Harvard Medical School), and Prof. Jane Mellor (Oxford Univ.), Prof. John O’Shea (National Institute of Health) and Prof. John Isaacs (New Castle Univ.) for their independent and critical review of our study. A list of Scottish Early Rheumatoid Arthritis (SERA) inception cohort investigators is provided in Additional fle 1: Additional Note. Funding This work was funded by Oxford BioDynamics.en
dc.format.extent11en
dc.language.isoeng
dc.relation.ispartofJournal of translational medicineen
dc.rights© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectEarly rheumatoid arthritisen
dc.subjectMethotrexateen
dc.subjectRheumatoid arthritisen
dc.subjectDMARDs (synthetic)en
dc.subjectPrecision medicine drug response biomarkersen
dc.subjectMethotrexate (MTX)en
dc.subjectChromatin conformation signatures (CCS)en
dc.subjectExpression quantitative trait loci (eQTL)en
dc.subjectR Medicine (General)en
dc.subject.lccR1en
dc.titleChromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritisen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen, Medicine, Medical Sciences & Nutrition, Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen, Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen, Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen, Data Safe Havenen
dc.contributor.institutionUniversity of Aberdeen, Epidemiology Groupen
dc.contributor.institutionUniversity of Aberdeen, Institute of Applied Health Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttp://dx.doi.org/10.1186/s12967-018-1387-9


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