dc.contributor.author | Carini, Claudio | |
dc.contributor.author | Hunter, Ewan | |
dc.contributor.author | Ramadass, Aroul S. | |
dc.contributor.author | Green, Jayne | |
dc.contributor.author | Akoulitchev, Alexandre | |
dc.contributor.author | McInnes, Iain B. | |
dc.contributor.author | Goodyear, Carl S. | |
dc.contributor.author | Liversidge, Janet | |
dc.contributor.author | Reid, David | |
dc.contributor.author | Basu, Neil | |
dc.date.accessioned | 2018-02-13T12:26:06Z | |
dc.date.available | 2018-02-13T12:26:06Z | |
dc.date.issued | 2018-01-29 | |
dc.identifier.citation | Carini , C , Hunter , E , Scottish Early Rheumatoid Arthritis Inception cohort Investigators , Ramadass , A S , Green , J , Akoulitchev , A , McInnes , I B & Goodyear , C S 2018 , ' Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis ' Journal of translational medicine , vol. 16 , 18 , pp. 1-11 . DOI: 10.1186/s12967-018-1387-9 | en |
dc.identifier.issn | 1479-5876 | |
dc.identifier.other | PURE: 115923372 | |
dc.identifier.other | PURE UUID: 5039f046-fa06-4324-a84d-4435d58e1896 | |
dc.identifier.other | RIS: urn:55CD676F9684B92CC2C04CFB25F024A4 | |
dc.identifier.other | RIS: Carini2018 | |
dc.identifier.other | Scopus: 85041231810 | |
dc.identifier.uri | http://hdl.handle.net/2164/10036 | |
dc.description | The authors would like to thank members of OBD Reference Facility Benjamin Foulkes, Chloe Bird, Emily Corfeld and Matthew Salter for expedient processing of clinical samples on the EpiSwitch™ platform and Magdalena Jeznach and Willem Westra for help with preparation of the manuscript. The study employed samples from the SERA Biobank used with permission and approval of the SERA Approval Group. We gratefully acknowledge the invaluable contribution of the clinicians and operating team in SERA. We would also like to thank Prof. Raju Kucherlapati (Harvard Medical School), and Prof. Jane Mellor (Oxford Univ.), Prof. John O’Shea (National Institute of Health) and Prof. John Isaacs (New Castle Univ.) for their independent and critical review of our study. A list of Scottish Early Rheumatoid Arthritis (SERA) inception cohort investigators is provided in Additional fle 1: Additional Note. Funding This work was funded by Oxford BioDynamics. | en |
dc.format.extent | 11 | en |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of translational medicine | en |
dc.rights | © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en |
dc.subject | Early rheumatoid arthritis | en |
dc.subject | Methotrexate | en |
dc.subject | Rheumatoid arthritis | en |
dc.subject | DMARDs (synthetic) | en |
dc.subject | Precision medicine drug response biomarkers | en |
dc.subject | Methotrexate (MTX) | en |
dc.subject | Chromatin conformation signatures (CCS) | en |
dc.subject | Expression quantitative trait loci (eQTL) | en |
dc.subject | R Medicine (General) | en |
dc.subject.lcc | R1 | en |
dc.title | Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis | en |
dc.type | Journal article | en |
dc.contributor.institution | University of Aberdeen, Applied Medicine | en |
dc.contributor.institution | University of Aberdeen, Other Applied Health Sciences | en |
dc.contributor.institution | University of Aberdeen, Data Safe Haven | en |
dc.contributor.institution | University of Aberdeen, Epidemiology Group | en |
dc.contributor.institution | University of Aberdeen, Institute of Applied Health Sciences | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Publisher PDF | en |
dc.identifier.doi | https://doi.org/10.1186/s12967-018-1387-9 | |