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dc.contributor.authorTesta, Andrea
dc.contributor.authorLucas, Xavier
dc.contributor.authorCastro, Guilherme
dc.contributor.authorChan, Kwok-Ho
dc.contributor.authorWright, Jane E.
dc.contributor.authorRuncie, Andrew C.
dc.contributor.authorGadd, Morgan S.
dc.contributor.authorHarrison, William T. A.
dc.contributor.authorKo, Eun-Jung
dc.contributor.authorFletcher, Daniel
dc.contributor.authorCiulli, Alessio
dc.date.accessioned2018-07-16T11:53:09Z
dc.date.available2018-07-16T11:53:09Z
dc.date.issued2018
dc.identifier.citationTesta , A , Lucas , X , Castro , G , Chan , K-H , Wright , J E , Runcie , A C , Gadd , M S , Harrison , W T A , Ko , E-J , Fletcher , D & Ciulli , A 2018 , ' 3-Fluoro-4-hydroxyprolines : Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation ' Journal of the American Chemical Society , vol. 140 , no. 29 , pp. 9299-9313 . DOI: 10.1021/jacs.8b05807en
dc.identifier.issn0002-7863
dc.identifier.otherPURE: 125973411
dc.identifier.otherPURE UUID: 77896a5b-69a4-40cf-8fdb-c2d4a55669db
dc.identifier.otherScopus: 85049368469
dc.identifier.urihttp://hdl.handle.net/2164/10750
dc.descriptionFunding Sources This project has received funding from the European Research Council (ERC) under the European Union’s Seventh Framework Programme (FP7/2007-2013) as a Starting Grant to A.C. (grant agreement No. ERC-2012-StG-311460 DrugE3CRLs). X.L. and K.-H. C. were supported by Marie Skłodowska-Curie Actions Individual Fellowships from the European Commission (H2020-MSCA-IF-2015-806323 and H2020-MSCA-IF-2014-655516, respectively). G. C. was supported by a Ph.D. Studentship from the Ministério da Educação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, No. 7148-14-3). Biophysics and drug discovery activities are supported by Wellcome Trust strategic awards to Dundee (100476/Z/12/Z and 094090/Z/10/Z, respectively). We thank Professor B. Linclau for helpful discussions, P. Fyfe for support with in-house X-ray facilities, and to the Diamond Light Source for beamtime (BAG proposal MX10071) and beamline support at beamline I04-1.en
dc.format.extent15en
dc.language.isoeng
dc.relation.ispartofJournal of the American Chemical Societyen
dc.rightsACS AuthorChoice - This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. https://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html https://creativecommons.org/licenses/by/4.0/en
dc.subjectQD Chemistryen
dc.subjectEuropean Research Councilen
dc.subjectFP7/2007-2013en
dc.subjectERC-2012-StG-311460 DrugE3CRLsen
dc.subjectEuropean Commissionen
dc.subjectH2020-MSCA-IF-2015-806323en
dc.subjectH2020-MSCA-IF-2014-655516en
dc.subjectWellcome Trusten
dc.subject100476/Z/12/Zen
dc.subject094090/Z/10/Zen
dc.subject.lccQDen
dc.title3-Fluoro-4-hydroxyprolines : Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradationen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen, Chemistryen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1021/jacs.8b05807


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