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Title: Systematic review of the safety and efficacy of foam sclerotherapy for venous disease of the lower limbs
Authors: Jia, Xueli
Mowatt, Graham
Burr, Jennifer Margaret
Cassar, Kevin
Cook, Jonathan Alistair
Fraser, Cynthia Mary
Keywords: Varicose veins
Sclerotherapy
Systematic review
Issue Date: 2007
Publisher: Wiley
Citation: Jia, X., Mowatt, G., Burr, J.M., Cassar, K., Cook, J., and Fraser, C. (2007) Systematic review of the safety and efficacy of foam sclerotherapy for venous disease of the lower limbs. British Journal of Surgery, 94(8), pp. 925-936.
Abstract: Background: Foam sclerotherapy is a potential treatment for lower limb venous disease. Methods: A systematic review, with no restriction on study design, to assess the safety and efficacy of foam sclerotherapy. Results: 69 studies were included. For serious adverse events including pulmonary embolism and deep vein thrombosis, the median event rates were less than 1%. Median rate for visual disturbance was 1.4%. Median rates for some other adverse events were more common, including headache (4.2%), thrombophlebitis (4.7%), matting/skin staining/pigmentation (17.8%) and pain at the site of injection (25.6%). Median rate for complete occlusion of treated veins was 87.0% and for recurrence or development of new veins was 8.1%. Evidence from meta-analysis for complete occlusion suggests that foam sclerotherapy is associated with a lower rate compared with surgery (RR 0.86, 95% CI 0.67 to 1.10) and a higher rate compared with liquid sclerotherapy (RR 1.39, 95% CI 0.91 to 2.11). However, there was substantial heterogeneity across the studies in the meta-analysis. Conclusion: Serious adverse events were rare. There is insufficient evidence to reliably compare the effectiveness of foam sclerotherapy with other minimally invasive therapies or surgery. Evidence from high quality randomised controlled trials is required.
URI: http://hdl.handle.net/2164/163
ISSN: 0007-1323
Appears in Collections:Applied Health Sciences research
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