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Title: A Pragmatic Randomised, Controlled Trial of Intensive Care follow up programmes in improving Longer-term outcomes from critical illness : the PRACTICAL study
Authors: Cuthbertson, Brian
Rattray, Janice
Johnston, Marie
Wildsmith, J. Anthony
Wilson, Edward
Hernández, Rodolfo Andrés
Ramsay, Craig R
Hull, Alastair M.
Norrie, John David
Campbell, Marion Kay
University of Aberdeen, School of Medicine & Dentistry, Division of Applied Health Sciences
Keywords: Continuity of Patient Care
Critical Illness
Outcome Assessment
Quality of Life
Issue Date: 23-Jul-2007
Publisher: BioMed Central
Citation: Cuthbertson, B.H., Rattray, J., Wildsmith, J.A., Wilson, E., Hernandez, R., Ramsay, C, Hull, A.M., Norries, J., and Campbell, M. (2007). A Pragmatic Randomised, Controlled Trial of Intensive Care follow up programmes in improving Longer-term outcomes from critical illness : the PRACTICAL study. BMC Health Services Research [Online] 7(116). Available from: [Accessed 16 November 2007]
Abstract: Background: A number of intensive care (ICU) patients experience significant problems with physical, psychological, and social functioning for some time after discharge from ICU. These problems have implications not just for patients, but impose a continuing financial burden for the National Health Service. To support recovery, a number of hospitals across the UK have developed Intensive Care follow-up clinics. However, there is a lack of evidence base to support these, and this study aims to test the hypothesis that intensive care follow up programmes are effective and cost-effective at improving physical and psychological quality of life in the year after intensive care discharge. Methods/Design: This is a multi-centre, pragmatic, randomised controlled trial. Patients (n = 270) will be recruited prior to hospital discharge from three intensive care units in the UK, and randomised to one of two groups. The control group will receive standard in-hospital follow-up and the intervention group will participate in an ICU follow-up programme with clinic appointments 2–3 and 9 months after ICU discharge. The primary outcome measure is Health-related Quality of Life (HRQoL) 12 months after ICU discharge as measured by the Short Form-36. Secondary measures include: HRQoL at six months; Quality-adjusted life years using EQ-5D; posttraumatic psychopathology as measured by Davidson Trauma Scale; and anxiety and depression using the Hospital Anxiety and Depression Scale at both six and twelve months after ICU discharge. Contacts with health services in the twelve months after ICU discharge will be measured as part of the economic analysis. Discussion: The provision of intensive care follow-up clinics within the UK has developed in an ad hoc manner, is inconsistent in both the number of hospitals offering such a service or in the type of service offered. This study provides the opportunity to evaluate such services both in terms of patient benefit and cost-effectiveness. The results of this study therefore will inform clinical practice and policy with regard to the appropriate development of such services aimed at improving outcomes after intensive care.
ISSN: 1472-6963
Appears in Collections:Applied Health Sciences research
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