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|Title: ||The challenges faced in the design, conduct and analysis of surgical randomised controlled trials|
|Authors: ||Cook, Jonathan Alistair|
University of Aberdeen, School of Medicine & Dentistry, Division of Applied Health Sciences
|Keywords: ||Randomised Controlled Trials as Topic|
Surgical Procedures, Operative
|Issue Date: ||6-Feb-2009|
|Citation: ||Cook, J.A., (2009) The challenges faced in the design, conduct and analysis of surgical randomised controlled trials. Trials, 10 (9).|
|Abstract: ||Randomised evaluations of surgical interventions are rare; some interventions have been widely
adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial
(RCT) design has not become the default study design for the evaluation of surgical interventions.
Surgical trials are difficult to successfully undertake and pose particular practical and methodological challenges. However, RCTs have played a role in the assessment of surgical innovations and there is scope and need for greater use. This article will consider the design, conduct and analysis of an RCT of a surgical intervention. The issues will be reviewed under three
headings: the timing of the evaluation, defining the research question and trial design issues.
Recommendations on the conduct of future surgical RCTs are made. Collaboration between
research and surgical communities is needed to address the distinct issues raised by the assessmentof surgical interventions and enable the conduct of appropriate and well-designed trials.|
|Appears in Collections:||Applied Health Sciences research|
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