Browsing by Author "Chandran, Siddharthan"
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Item 40 Years of CSF Toxicity Studies in ALS : What Have We Learnt About ALS Pathophysiology?(2021-03-18) Ng Kee Kwong, Koy Chong; Harbham, Pratap K.; Selvaraj, Bhuvaneish T.; Gregory, Jenna; Pal, Suvankar; Hardingham, Giles E.; Chandran, Siddharthan; Mehta, Arpan R.; University of Aberdeen.Medical Sciences; University of Aberdeen.NeuroscienceItem C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity(2018-01-24) Selvaraj, Bhuvaneish T.; Livesey, Matthew R.; Zhao, Chen; Gregory, Jenna M.; James, Owain T.; Cleary, Elaine M.; Chouhan, Amit K.; Gane, Angus B.; Perkins, Emma M.; Dando, Owen; Lillico, Simon G.; Lee, Youn Bok; Nishimura, Agnes L.; Poreci, Urjana; Thankamony, Sai; Pray, Meryll; Vasistha, Navneet A.; Magnani, Dario; Borooah, Shyamanga; Burr, Karen; Story, David; McCampbell, Alexander; Shaw, Christopher E.; Kind, Peter C.; Aitman, Timothy J.; Whitelaw, C. Bruce A.; Wilmut, Ian; Smith, Colin; Miles, Gareth B.; Hardingham, Giles E.; Wyllie, David J.A.; Chandran, Siddharthan; University of Aberdeen.Medical SciencesItem Cerebrospinal fluid cytotoxicity in amyotrophic lateral sclerosis : a systematic review of in vitro studies(2020-08-06) Ng Kee Kwong, Koy Chong; Gregory, Jenna; Pal, Suvankar; Chandran, Siddharthan; Mehta, Arpan R.; University of Aberdeen.Medical SciencesItem Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective(2021-10-01) Wong, Charis; Stavrou, Maria; Elliott, Elizabeth; Gregory, Jenna; Leigh, Nigel; Pinto, Ashwin A.; Williams, Timothy L.; Chataway, Jeremy; Swingler, Robert; Parmar, Mahesh K. B.; Stallard, Nigel; Weir, Christopher J; Parker, Richard A; Chaouch, Amina; Hamdalla, Hisham; Ealing, John; Gorrie, George; Morrison, Ian; Duncan, Callum W.; Connelly, Peter; Carod-Artal, Francisco Javier; Davenport, Richard; Reitboeck, Pablo Garcia; Radunovic, Aleksandar; Srinivasan , Venkataramanan; Preston, Jenny; Mehta, Arpan R.; Leighton, Danielle; Glasmacher, Stella; Beswick, Emily; Williamson, Jill; Stenson, Amy; Weaver, Christine; Newton, Judith; Chandran, Siddharthan; Dakin, Rachel; Lyle, Dawn; Pal, Suvankar; Macleod, Malcolm R.; University of Aberdeen.Medical Sciences; University of Aberdeen.NeuroscienceItem Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?(2019-05-21) Barton, Samantha Kate; Gregory, Jenna; Chandran, Siddharthan; Turner , Bradley J; University of Aberdeen.Medical SciencesItem The Dementias Platform UK (DPUK) data portal(2020-06) Bauermeister, Sarah; Orton, Christopher; Thompson, Simon; Barker, Roger A.; Bauermeister, Joshua R.; Ben-Shlomo, Yoav; Brayne, Carol; Burn, David; Campbell, Archie; Calvin, Catherine; Chandran, Siddharthan; Chaturvedi, Nishi; Chêne, Geneviève; Chessell, Iain P.; Corbett, Anne; Davis, Daniel H. J.; Denis, Mike; Dufouil, Carole; Elliott, Paul; Fox, Nick; Hill, Derek; Hofer, Scott M.; Hu, Michele T.; Jindra, Christoph; Kee, Frank; Kim, Chi-Hun; Kim, Changsoo; Kivimaki, Mika; Koychev, Ivan; Lawson, Rachael A.; Linden, Gerry J.; Lyons, Ronan A.; Mackay, Clare; Matthews, Paul M.; McGuiness, Bernadette; Middleton, Lefkos; Moody, Catherine; Moore, Katrina; Na, Duk L.; O'Brien, John T.; Ourselin, Sebastien; Paranjothy, Shantini; Park, Ki-Soo; Porteous, David J.; Richards, Marcus; Ritchie, Craig W.; Rohrer, Jonathan D.; Rossor, Martin N.; Rowe, James B.; Scahill, Rachael; Schnier, Christian; Schott, Jonathan M.; Seo, Sang W.; South, Matthew; Steptoe, Matthew; Tabrizi, Sarah J.; Tales, Andrea; Tillin, Therese; Timpson, Nicholas J.; Toga, Arthur W.; Visser, Pieter-Jelle; Wade-Martins, Richard; Wilkinson, Tim; Williams, Julie; Wong, Andrew; Gallacher, John E. J.; University of Aberdeen.Other Applied Health SciencesItem Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis.(2021-09-21) Gregory, Jenna; Barton, Samantha K.; Selvaraj, Bhuvaneish T.; McDade, Karina; Henstridge, Christopher M.; Spires-Jones, Tara L.; James, Owen G.; Mehta, Arpan R.; Story, David; Burr, Karen; Magnani, Dario; Isaacs, Adrian M.; Smith, Colin; Chandran, Siddharthan; University of Aberdeen.Medical Sciences; University of Aberdeen.NeuroscienceItem Executive, language and fluency dysfunction are markers of localised TDP-43 cerebral pathology in non-demented ALS(2020-02) Gregory, Jenna; McDade, Karina; Bak, Thomas H; Pal, Suvankar; Chandran, Siddharthan; Smith, Colin; Abrahams, Sharon; University of Aberdeen.Medical SciencesItem Improved detection of RNA foci in C9orf72 amyotrophic lateral sclerosis post-mortem tissue using BaseScope™ shows a lack of association with cognitive dysfunction(2020-01) Mehta, Arpan R.; Barton, Samantha K.; McDade, Karina; Abrahams, Sharon; Chandran, Siddharthan; Smith, Colin; Gregory, Jenna; University of Aberdeen.Medical SciencesItem Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis(2021-02) Mehta, Arpan R.; Gregory, Jenna; Dando, Owen; Carter, Roderick N.; Burr, Karen; Nanda, Jyoti; Story, David; McDade, Karina; Smith, Colin; Morton, Nicholas M.; Mahad, Don J.; Hardingham, Giles E.; Chandran, Siddharthan; Selvaraj, Bhuvaneish T.; University of Aberdeen.Medical Sciences; University of Aberdeen.NeuroscienceItem Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART) : a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease(2022-07-07) Wong, Charis; Dakin, Rachel S; Williamson, Jill; Newton, Judith; Steven, Michelle; Colville, Shuna; Stavrou, Maria; Gregory, Jenna M; Elliott, Elizabeth; Mehta, Arpan R; Chataway, Jeremy; Swingler, Robert J; Parker, Richard Anthony; Weir, Christopher J; Stallard, Nigel; Parmar, Mahesh K B; Macleod, Malcolm R; Pal, Suvankar; Chandran, Siddharthan; University of Aberdeen.Medical Sciences; University of Aberdeen.NeuroscienceItem Neuronal clusterin expression is associated with cognitive protection in amyotrophic lateral sclerosis(2020-05-18) Gregory, J. M.; Elliott, E.; McDade, K.; Bak, T.; Pal, Suvankar; Chandran, Siddharthan; Abrahams, Sharon; Smith, C.; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical SciencesItem NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis(2022-03) Banerjee, Poulomi; Elliott, Elizabeth; Rifai, Olivia M; O'shaughnessy, Judi; McDade, Karina; Abrahams, Sharon; Chandran, Siddharthan; Smith, Colin; Gregory, Jenna; University of Aberdeen.Medical Sciences; University of Aberdeen.NeuroscienceItem Probing TDP-43 condensation using an in silico designed aptamer(2022-06-23) Zacco, Elsa; Kantelberg, Owen; Milanetti, Edoardo; Armaos, Alexandros; Panei, Francesco Paolo; Gregory, Jenna; Jeacock, Kiani; Clarke, David J.; Chandran, Siddharthan; Ruocco, Giancarlo; Gustincich, Stefano; Horrocks, Mathew; Pastore, Annalisa; Tartaglia, Gian Gaetano; University of Aberdeen.Medical Sciences; University of Aberdeen.NeuroscienceItem Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72-ALS(2022-12) Rifai, Olivia M.; Longden, James; O'Shaughnessy, Judi; Sewell, Michael D.E.; Pate, Judith; McDade, Karina; Daniels, Michael J.D.; Abrahams, Sharon; Chandran, Siddharthan; McColl, Barry W.; Sibley, Christopher R.; Gregory, Jenna M.; University of Aberdeen.Medical Sciences; University of Aberdeen.NeuroscienceItem Random forest modelling of neuropathological features identifies microglial activation as an accurate pathological classifier of C9orf72-related amyotrophic lateral sclerosis(bioRxiv, 2021-12-10) Rifai, Olivia M.; Longden, James; O’Shaughnessy, Judi; Sewell, Michael D.E.; McDade, Karina; Daniels, Michael J.D.; Abrahams, Sharon; Chandran, Siddharthan; McColl, Barry; Sibley, Christopher R.; Gregory, Jenna M.; University of Aberdeen.Medical Sciences; University of Aberdeen.NeuroscienceItem Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology(2022-01-10) Jiwaji, Zoeb; Tiwari, Sachin S.; Avilés-Reyes, Rolando X.; Hooley, Monique; Hampton, David; Torvell, Megan; Johnson, Delinda A.; McQueen, Jamie; Baxter, Paul; Sabari-Sankar, Kayalvizhi; Qiu, Jing; He, Xin; Fowler, Jill; Febery, James; Gregory, Jenna; Rose, Jamie; Tulloch, Jane; Loan, Jamie; Story, David; McDade, Karina; Smith, Amy M.; Greer, Peta; Ball, Matthew; Kind, Peter C.; Matthews, Paul M.; Smith, Colin; Dando, Owen; Spires-Jones, Tara L.; Johnson, Jeffrey A.; Chandran, Siddharthan; Hardingham, Giles E.Item Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis(2020-08) Gregory, J. M.; McDade, K.; Livesey, M. R.; Croy, I.; Marion de Proce, S.; Aitman, T.; Chandran, Siddharthan; Smith, C.; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Natural & Computing SciencesItem A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease(MedRxiv, 2022-04-22) Wong, Charis; Gregory, Jenna; Liao, Jing; Egan, Kieren; Vesterinen, Hanna M.; Khan, Aimal Ahmad; Anwar, Maarij; Beagan, Caitlin; Brown, Fraser; Cafferkey, John; Cardinali, Alessandra; Chiam, Jane Yi; Chiang, Claire; Collins, Victoria; Dormido, Joyce; Elliott, Elizabeth; Foley, Peter; Foo, Yu Cheng; Fulton-Humble, Lily; Gane, Angus B.; Glasmacher, Stella; Heffernan, Áine; Jayaprakash, Kiran; Jayasuriya, Nimesh; Kaddouri, Amina; Kiernan, Jamie; Langlands, Gavin; Leighton, Danielle; Liu, Jiaming; Lyon, James; Mehta, Arpan R.; Meng, Alyssa; Nguyen, Vivienne; Park, Kyu Hyung; Quigley, Suzanne; Rashid, Yousuf; Salzinger, Andrea; Shiell, Bethany; Singh, Ankur; Soane, Tim; Thompson, Alexandra; Tomala, Olaf; Waldron, Fergal M.; Selvaraj, Bhuvaneish T.; Chataway, Jeremy; Swingler, Robert; Connick, Peter; Pal, Suvankar; Chandran, Siddharthan; Macleod, Malcolm R.; University of Aberdeen.Neuroscience; University of Aberdeen.Medical SciencesItem Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease : Using systematic reviews to inform expert consensus(2023-02) Wong, Charis; Gregory, Jenna M.; Liao, Jing; Egan, Kieren; Vesterinen, Hanna M.; Ahmad Khan, Aimal; Anwar, Maarij; Beagan, Caitlin; Brown, Fraser S.; Cafferkey, John; Cardinali, Alessandra; Chiam, Jane Yi; Chiang, Claire; Collins, Victoria; Dormido, Joyce; Elliott, Elizabeth; Foley, Peter; Foo, Yu Cheng; Fulton-Humble, Lily; Gane, Angus B.; Glasmacher, Stella A.; Heffernan, Áine; Jayaprakash, Kiran; Jayasuriya, Nimesh; Kaddouri, Amina; Kiernan, Jamie; Langlands, Gavin; Leighton, D.; Liu, Jiaming; Lyon, James; Mehta, Arpan R.; Meng, Alyssa; Nguyen, Vivienne; Park, Na Hyun; Quigley, Suzanne; Rashid, Yousuf; Salzinger, Andrea; Shiell, Bethany; Singh, Ankur; Soane, Tim; Thompson, Alexandra; Tomala, Olaf; Waldron, Fergal M.; Selvaraj, Bhuvaneish T.; Chataway, Jeremy; Swingler, Robert; Connick, Peter; Pal, Suvankar; Chandran, Siddharthan; Macleod, Malcolm; University of Aberdeen.Medical Sciences; University of Aberdeen.Neuroscience; University of Aberdeen.Applied Medicine