Browsing by Author "Harrington, Charles R"
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Item Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking(2017-11-24) Al-Hilaly, Youssra K; Pollack, Saskia J; Vadukul, Devkee; Citossi, Francesca; Rickard, Janet E; Simpson, Michael; Storey, John M D; Harrington, Charles R; Wischik, Claude M; Serpell, Louise C; University of Aberdeen.Applied Medicine; University of Aberdeen.Chemistry; University of Aberdeen.Medical SciencesItem Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease(2015-04-24) Harrington, Charles R; Storey, John M D; Clunas, Scott; Harrington, Kathleen A; Horsley, David; Ishaq, Ahtsham; Kemp, Steven J; Larch, Christopher P; Marshall, Colin; Nicoll, Sarah L; Rickard, Janet E; Simpson, Michael; Sinclair, James P; Storey, Lynda J; Wischik, Claude M; University of Aberdeen.Medical Sciences; University of Aberdeen.Chemistry; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Applied MedicineItem Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration(2020-03-30) Cranston, Anna L; Wysocka, Adrianna; Steczkowska, Marta; Zadrozny, Maciej; Palasz, Ewelina; Harrington, Charles R; Theuring, Franz; Wischik, Claude; Riedel, Gernot; Niewiadomska, Grazyna; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease(2024-05-21) Penny, Lewis K; Lofthouse, Richard; Arastoo, Mohammad; Porter, Andy; Palliyil, Soumya; Harrington, Charles R; Wischik, Claude M; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Medical Sciences; University of Aberdeen.Microbiology and Immunity; University of Aberdeen.Neuroscience; University of Aberdeen.Farr Aberdeen; University of Aberdeen.Applied MedicineItem Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease(2020-11-26) Arastoo, Mohammad; Lofthouse, Richard; Penny, Lewis; Harrington, Charles R; Porter, Andy; Wischik, Claude M; Palliyil, Soumya; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia(2020-12-25) Lemke, Nora; Melis, Valeria; Lauer, Dilyara; Magbagbeolu, Mandy; Neumann, Boris; Harrington, Charles R; Riedel, Gernot; Wischik, Claude M.; Theuring, Franz; Schwab, Karima; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models(2015-06) Melis, Valeria; Magbagbeolu, Mandy; Rickard, Janet E; Horsley, David; Davidson, Kathleen; Harrington, Kathleen A; Goatman, Keith; Goatman, Elizabeth A; Deiana, Serena; Close, Steve P; Zabke, Claudia; Stamer, Karsten; Dietze, Silke; Schwab, Karima; Storey, John M D; Harrington, Charles R; Wischik, Claude M; Theuring, Franz; Riedel, Gernot; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Epidemiology Group; University of Aberdeen.Chemistry; University of Aberdeen.Medical SciencesItem Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease : a randomised, controlled, double-blind, parallel-arm, phase 3 trial(2016-12) Gauthier, Serge; Feldman, Howard H; Schneider, Lon S; Wilcock, Gordon K; Frisoni, Giovanni B; Hardlund, Jiri H; Moebius, Hans J; Bentham, Peter; Kook, Karin A; Wischik, Damon J; Schelter, Bjoern O; Davis, Charles S; Staff, Roger T; Bracoud, Luc; Shamsi, Kohkan; Storey, John M D; Harrington, Charles R; Wischik, Claude M; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Medical Sciences; University of Aberdeen.Chemistry; University of Aberdeen.Applied MedicineItem Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine(2022) Kondak, Constantin; Riedel, Gernot; Harrington, Charles R; Wischik, Claude M; Klein, Jochen; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)(2019) König, Magdalena; Berlin, Beata; Schwab, Karima; Frahm, Silke; Theuring, Franz; Wischik, Claude M; Harrington, Charles R; Riedel, Gernot; Klein, Jochen; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical SciencesItem A Meta-Analysis on Presynaptic Changes in Alzheimer's Disease(2024-01-02) Anschuetz, Anne; Schwab, Karima; Harrington, Charles R; Wischik, Claude M; Riedel, Gernot; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Applied Medicine; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical SciencesItem Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice(2023-06-28) Kondak, Constantin; Leith, Michael; Baddeley, Thomas C; Santos, Renato X; Harrington, Charles R; Wischik, Claude M; Riedel, Gernot; Klein, Jochen; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Chemistry; University of Aberdeen.Medical Sciences; University of Aberdeen.Neuroscience; University of Aberdeen.Applied MedicineItem Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development(2018-03-13) Wischik, Claude M; Schelter, Björn O; Wischik, Damon J; Storey, John M D; Harrington, Charles R; University of Aberdeen.Applied Medicine; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Chemistry; University of Aberdeen.Medical SciencesItem Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model(2024-04-06) Zadrozny, Maciej; Drapich, Patrycja; Gasiorowska-Bien, Anna; Niewiadomski, Wiktor; Harrington, Charles R; Wischik, Claude M; Riedel, Gernot; Niewiadomska, Grazyna; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Applied MedicineItem The Neurovascular Unit Dysfunction in Alzheimer's Disease(2021-02-18) Soto-Rojas, Luis O; Pacheco-Herrero, Mar; Martínez-Gómez, Paola A; Campa-Córdoba, B Berenice; Apátiga-Pérez, Ricardo; Villegas-Rojas, Marcos M; Harrington, Charles R; de la Cruz, Fidel; Garcés-Ramírez, Linda; Luna-Muñoz, José; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical SciencesItem PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer’s Disease(2020-09-10) Luna-Viramontes, Nabil Itzi; Campa-Córdoba, B. Berenice; Ontiveros-Torres, Miguel Angel; Harrington, Charles R; Villanueva-Fierro, Ignacio; Guadarrama-Ortíz, Parménides; Garcés-Ramírez, Linda; de la Cruz, Fidel; Hernandes-Alejandro, Mario; Martínez-Robles, Sandra; González-Ballesteros, Erik; Pacheco-Herrero, Mar; Luna-Muñoz, José; University of Aberdeen.Medical SciencesItem Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease : Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial(2017-11-28) Wilcock, Gordon K; Gauthier, Serge; Frisoni, Giovanni B; Jia, Jianping; Hardlund, Jiri H; Moebius, Hans J; Bentham, Peter; Kook, Karin A; Schelter, Bjoern Olaf; Wischik, Damon J; Davis, Charles S; Staff, Roger T; Vuksanovic, Vesna; Ahearn, Trevor; Bracoud, Luc; Shamsi, Kohkan; Marek, Ken; Seibyl, John; Riedel, Gernot; Storey, John M. D.; Harrington, Charles R; Wischik, Claude M; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Aberdeen Biomedical Imaging Centre; University of Aberdeen.ChemistryItem A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy(2018-01-10) Schwab, Karima; Frahm, Silke; Horsley, David; Rickard, Janet E; Melis, Valeria; Goatman, Elizabeth A; Magbagbeolu, Mandy; Douglas, Morag; Leith, Michael G; Baddeley, Thomas C.; Storey, John M D; Riedel, Gernot; Wischik, Claude M; Harrington, Charles R; Theuring, Franz; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.ChemistryItem Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies(2010) Wischik, Claude M; Wischik, Damon J; Storey, John M D; Harrington, Charles R; Martinez, Ana; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.ChemistryItem The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease(2015-02-11) Flores-Rodríguez, Paola; Ontiveros-Torres, Miguel A; Cárdenas-Aguayo, María C; Luna-Arias, Juan P; Meraz-Ríos, Marco A; Viramontes-Pintos, Amparo; Harrington, Charles R; Wischik, Claude M; Mena, Raúl; Florán-Garduño, Benjamin; Luna-Muñoz, José; University of Aberdeen.Other Applied Health Sciences