Browsing by Author "Harrington, Charles R."
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Item Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease(2016-04-08) Lai, Robert Y. K.; Harrington, Charles R.; Wischik, Claude M.; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia(2020-05-19) Shiells, Helen; Schelter, Bjoern O.; Bentham, Peter; Baddeley, Thomas C.; Rubino, Christopher M.; Ganesan, Harish; Hammel, Jeffrey; Vuksanovic, Vesna; Staff, Roger T.; Murray, Alison D.; Bracoud, Luc; Wischik, Damon J.; Riedel, Gernot; Gauthier, Serge; Jia, Jianping; Moebius, Hans J.; Hardlund, Jiri; Kipps, Christopher M.; Kook, Karin; Storey, John M. D.; Harrington, Charles R.; Wischik, Claude M.; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Chemistry; University of Aberdeen.Applied Medicine; University of Aberdeen.Centre for Health Data Science; University of Aberdeen.Medical Sciences; University of Aberdeen.Grampian Data Safe Haven (DaSH); University of Aberdeen.Aberdeen Biomedical Imaging CentreItem Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease(2019-11-26) Schelter, Bjoern O.; Shiells, Helen; Baddeley, Thomas C.; Rubino, Christopher M.; Ganesan, Harish; Hammel, Jeffrey; Vuksanovic, Vesna; Staff, Roger T.; Murray, Alison D.; Bracoud, Luc; Riedel, Gernot; Gauthier, Serge; Jia, Jianping; Bentham, Peter; Kook, Karin; Storey, John M. D.; Harrington, Charles R.; Wischik, Claude M.; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Chemistry; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Grampian Data Safe Haven (DaSH); University of Aberdeen.Aberdeen Biomedical Imaging CentreItem Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)(2018-10-19) Al-Hilaly, Youssra K.; Pollack, Saskia J.; Rickard, Janet E.; Simpson, Michael; Raulin, Ana-C; Baddeley, Thomas; Schellenberger, Pascale; Storey, John M. D.; Harrington, Charles R.; Wischik, Claude M.; Serpell, Louise C.; University of Aberdeen.Applied Medicine; University of Aberdeen.Chemistry; University of Aberdeen.Medical SciencesItem Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro(2022-10-15) Maina, Mahmoud B.; Al-Hilaly, Youssra K.; Oakley, Sebastian; Burra, Gunasekhar; Khanom, Tahmida; Biasetti, Luca; Mengham, Kurtis; Marshall, Karen; Harrington, Charles R.; Wischik, Claude M.; Serpell, Louise C.; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Applied MedicineItem Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine : A Prospective Study of Phase 3 Clinical Trial Participants(2023-09-06) Arastoo, Mohammad; Mazanetz, Michael P.; Miller, Sonya; Shiells, Helen; Hull, Claire; Robinson, Keith; Storey, John M.D.; Harrington, Charles R.; Wischik, Claude M.; University of Aberdeen.Medical Sciences; University of Aberdeen.Chemistry; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Applied MedicineItem Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model : Effects of hydromethylthionine(2022-09-01) Schwab, Karima; Chasapopoulou, Zoi; Frahm, Silke; Magbagbeolu, Mandy; Cranston, Anna; Harrington, Charles R.; Wischik, Claude M.; Theuring, Franz; Riedel, Gernot; University of Aberdeen.Applied Medicine; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical SciencesItem HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine(2022-04-07) Santos, Renato X.; Melis, Valeria; Goatman, Elizabeth A.; Leith, Michael; Baddeley, Thomas C.; Storey, John M.D.; Riedel, Gernot; Wischik, Claude M.; Harrington, Charles R.; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Chemistry; University of Aberdeen.NeuroscienceItem Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies : interference by cholinesterase inhibitors(2024-06-15) Schwab, Karima; Lauer, Dilyara; Magbagbeolu, Mandy; Institute, Mossakowski; Institute, Mossakowski; Institute, Mossakowski; Harrington, Charles R.; Wischik, Claude M.; Niewiadomska, Grażyna; Riedel, Gernot; University of Aberdeen.Applied Medicine; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical SciencesItem A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine(2025-09-01) Al-Hilaly, Youssra K.; Rickard, Janet E.; Simpson, Michael; Storey, John M.D.; Harrington, Charles R.; Wischik, Claude M.; Serpell, Louise C.; University of Aberdeen.Applied Medicine; University of Aberdeen.Chemistry; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical SciencesItem Long-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier(2021-09-28) Bentham, Peter; Staff, Roger T.; Schelter, Bjoern O.; Shiells, Helen; Harrington, Charles R.; Wischik, Claude M.; University of Aberdeen.Medical Sciences; University of Aberdeen.Centre for Health Data Science; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Physics; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Applied MedicineItem Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model(2020-03-31) Riedel, Gernot; Klein, Jochen; Niewiadomska, Grazyna; Kondak, Constantin; Schwab, Karima; Lauer, Dilyara; Magbagbeolu, Mandy; Steczkowska, Marta; Zadrozny, Maciej; Wydrych, Malgorzata; Cranston, Anna; Melis, Valeria; Santos, Renato X.; Theuring, Franz; Harrington, Charles R.; Wischik, Claude M.; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Applied MedicineItem Molecular Processing of Tau Protein in Progressive Supranuclear Palsy : Neuronal and Glial Degeneration(2021-02-16) Martínez-Maldonado, Alejandra; Ontiveros-Torres, Miguel Ángel; Harrington, Charles R.; Montiel-Sosa, José Francisco; Prandiz, Raúl García-Tapia; Bocanegra-López, Patricia; Sorsby-Vargas, Andrew Michael; Bravo-Muñoz, Marely; Florán-Garduño, Benjamín; Villanueva-Fierro, Ignacio; Perry, George; Garcés-Ramírez, Linda; De La Cruz-López, Fidel; Martínez-Robles, Sandra; Pacheco-Herrero, Mar; Luna-Muñoz, José; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical SciencesItem Monoaminergic Neuropathology in Alzheimer's disease(2017-04) Šimić, Goran; Leko, Mirjana Babić; Wray, Selina; Harrington, Charles R.; Delalle, Ivana; Jovanov-Milošević, Nataša; Bažadona, Danira; Buée, Luc; Silva, Rohan de; Giovanni, Giuseppe Di; Wischik, Claude M.; Hof, Patrick R.; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates(2021-03-22) Maina, Mahmoud B.; Al-Hilaly, Youssra K.; Burra, Gunasekhar; Rickard, Janet E.; Harrington, Charles R.; Wischik, Claude M.; Serpell, Louise C.; University of Aberdeen.Applied Medicine; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical SciencesItem Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells(2020-08-07) Pollack, Saskia J.; Trigg, Jasmine; Khanom, Tahmida; Biasetti, Luca; Marshall, Karen E.; Al-Hilaly, Youssra K.; Rickard, Janet E.; Harrington, Charles R.; Wischik, Claude M.; Serpell, Louise C.; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Other Applied Health SciencesItem Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells : A Morphological Study(2019-09-17) Flores-Rodríguez, Paola; Harrington, Charles R.; Wischik, Claude M.; Ibarra-Bracamontes, Vanessa; Zarco, Natanael; Navarrete, Araceli; Martínez-Maldonado, Alejandra; Guadarrama-Ortíz, Parménides; Villanueva-Fierro, Ignacio; Ontiveros-Torres, Miguel Angel; Perry, George; Alonso, Alejandra D.; Florán-Garduño, Benjamin; Segovia, José; Luna-Muñoz, José; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Proteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks(2021-08-22) Schwab, Karima; Melis, Valeria; Harrington, Charles R.; Wischik, Claude M.; Magbagbeolu, Mandy; Theuring, Franz; Riedel, Gernot; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.NeuroscienceItem Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)(2022-12-08) Al-Hilaly, Youssra K.; Hurt, Connor; Rickard, Janet E.; Harrington, Charles R.; Storey, John M.D.; Wischik, Claude M.; Serpell, Louise C.; Siemer, Ansgar B.; University of Aberdeen.Applied Medicine; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.ChemistryItem Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer’s Disease : Systematic Review and Meta-Analysis(2023-04-18) Zabala-Findlay, Alex; Penny, Lewis K.; Lofthouse, Richard A.; Porter, Andrew J.; Palliyil, Soumya; Harrington, Charles R.; Wischik, Claude M.; Arastoo, Mohammad; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Neuroscience; University of Aberdeen.Applied Medicine