Browsing by Author "Lois, Noemi"

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Clinical and cost-effectiveness of internal limiting membrane peeling for patients with idiopathic full thickness macular hole. Protocol for a Randomised Controlled Trial : FILMS (Full-thickness macular hole and Internal Limiting Membrane peeling Study)
(BMC, 2008-11-03) Lois, Noemi; Burr, Jennifer Margaret; Norrie, John David; Vale, Luke David; Cook, Jonathan Alistair; McDonald, Alison Mary; FILMS Group; University of Aberdeen, School of Medicine & Dentistry, Division of Applied Health Sciences
Background: A full-thickness macular hole (FTMH) is a common retinal condition associated with impaired vision. Randomised controlled trials (RCTs) have demonstrated that surgery, by means of pars plana vitrectomy and post-operative intraocular tamponade with gas, is effective for stage 2, 3 and 4 FTMH. Internal limiting membrane (ILM) peeling has been introduced as an additional surgical manoeuvre to increase the success of the surgery; i.e. increase rates of hole closure and visual improvement. However, little robust evidence exists supporting the superiority of ILM peeling compared with no-peeling techniques. The purpose of FILMS (Fullthickness macular hole and Internal Limiting Membrane peeling Study) is to determine whether ILM peeling improves the visual function, the anatomical closure of FTMH, and the quality of life of patients affected by this disorder, and the cost-effectiveness of the surgery. Methods/Design: Patients with stage 2–3 idiopathic FTMH of less or equal than 18 months duration (based on symptoms reported by the participant) and with a visual acuity ≤ 20/40 in the study eye will be enrolled in this FILMS from eight sites across the UK and Ireland. Participants will be randomised to receive combined cataract surgery (phacoemulsification and intraocular lens implantation) and pars plana vitrectomy with postoperative intraocular tamponade with gas, with or without ILM peeling. The primary outcome is distance visual acuity at 6 months. Secondary outcomes include distance visual acuity at 3 and 24 months, near visual acuity at 3, 6, and 24 months, contrast sensitivity at 6 months, reading speed at 6 months, anatomical closure of the macular hole at each time point (1, 3, 6, and 24 months), health related quality of life (HRQOL) at six months, costs to the health service and the participant, incremental costs per quality adjusted life year (QALY) and adverse events. Discussion: FILMS will provide high quality evidence on the role of ILM peeling in FTMH surgery. Trial registration: This trial is registered with Current Controlled Trials ISRCTN number 33175422 and Clinical Trials.gov identifier NCT00286507.
Diabetic Macular Edema and Diode Subthreshold Micropulse Laser : A Randomized Double-Masked Noninferiority Clinical Trial
(2023-01) Lois, Noemi; Campbell, Christina; Waugh, Norman; Azuara-Blanco, Augusto; Maredza, Mandy; Mistry, Hema; McAuley, Danny; Acharya, Nachiketa; Aslam, Tariq M.; Bailey, Clare; Chong, Victor; Downey, Louise; Eleftheriadis, Haralabos; Fatum, Samia; George, Sheena; Ghanchi, Faruque; Groppe, Markus; Hamilton, Robin; Menon, Geeta; Saad, Ahmed; Sivaprasad, Sobha; Shiew, Marianne; Steel, David H.; Talks, James Stephen; Doherty, Paul; McDowell, Cliona; Clarke, Mike; DIAMONDS Study Group; University of Aberdeen.Other Applied Health Sciences
The Effect of Macular Hole Duration on Surgical Outcomes : An Individual Participant Data Study of Randomized Controlled Trials
(2023-02-01) Murphy, Declan C.; Al-Zubaidy , Mo; Lois, Noemi; Scott, Neil; Steel, David H; Qu, Jinfeng; Zhao, Mingwei; Sadda, Srinivas; Manasa, Sreekumar; Agarwal, Divya; Kumar, Atul; Kakkar, Prateek; Bourgault, Serge; Tourville, Eric; Velez-Montoya, Raul; Hernandez-Da Mota, Sergio E.; Ramirez-Estudillo, J. Abdel; Nawrocki, Jerzy; Nawrocka, Zofia Anna; Lange, Clemens; Bainbridge, James; Yorston, David; Alberti, Mark; la Cour, Morten; Christensen, Ulrik; Ho Alvin, Kwok Kwan; Macular Hole Duration Study Group; University of Aberdeen.Medical Statistics; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences
The Epidemiology of Stargardt Disease in the United Kingdom
(2017-11) Spiteri Cornish, Kurt; Ho, Jason; Downes, Susan; Scott, Neil W; Bainbridge, James; Lois, Noemi; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Medical Statistics; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Applied Medicine
Instrumental variable methods for a binary outcome were used to informatively address non-compliance in a randomised trial in surgery
(2018-04) Cook, Jonathan A; Maclennan, Graeme S; Palmer, Tom; Lois, Noemi; Emsley, Richard; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences
Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology
(2018-11) Cao, Lin; Liu, Jie; Pu, Jin; Milne, Gillian; Chen, Mei; Xu, Heping; Shipley, Alan; Forrester, John V; McCaig, Colin D.; Lois, Noemi; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Aberdeen Centre for Evaluation