Browsing by Author "MacKenzie, Alasdair"
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Item Allele-specific differences in activity of a novel cannabinoid receptor 1 (CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia, and hippocampus(2012-04-13) Nicoll, Gemma; Davidson, Scott; Shanley, Lynne; Hing, Ben; Lear, Marissa; McGuffin, Peter; Ross, Ruth; MacKenzie, Alasdair; University of Aberdeen.Medical SciencesItem An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome(2017-08) Hay, Elizabeth Anne; Khalaf, Abdulla Razak; Marini, Pietro; Brown, Andrew; Heath, Karyn; Sheppard, Darrin; MacKenzie, Alasdair; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Medical Education; University of Aberdeen.Biological SciencesItem An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans(2024-03-01) McEwan, Andrew Robert; Hing, Benjamin; Erickson, Johanna C.; Hutchings, Greg; Urama, Charity; Norton-Hughes, Emily; D'Ippolito, Mariam; Berry, Susan; Delibegovic, Mirela; Grassmann, Felix; MacKenzie, Alasdair; University of Aberdeen.Medical Sciences; University of Aberdeen.Molecular and Cellular Function; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Applied MedicineItem The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet(2021-03) McEwan, Andrew; Erickson, Johanna Celene; Davidson, Connor; Heijkoop, Jenny; Turnbull, Yvonne; Delibegovic, Mirela; Murgatroyd , Christopher; MacKenzie, Alasdair; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medical Sciences; University of Aberdeen.Vice Principals; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Molecular and Cellular FunctionItem Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities(2022-06) MacKenzie, Alasdair; Hay, Elizabeth A; McEwan, Andrew R; University of Aberdeen.Molecular and Cellular Function; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Institute of Medical SciencesItem CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake(2019-12-13) Mcewan, Andrew; Hay, Elisabeth; Davidson, Connor; Turnbull, Yvonne; Erickson, Johanna Celene; Marini, Pietro; Wilson, Dana; McIntosh, Andrew M.; Adams, Mark J.; Murgatroyd, Chris; Barrett, Perry; Delibegovic, Mirela; Clarke, Toni-Kim; MacKenzie, Alasdair; University of Aberdeen.Medical Education; University of Aberdeen.Rowett Institute; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Medical SciencesItem CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake(2021-06) McEwan, Andrew R; Davidson, Connor; Hay, Elizabeth; Turnbull, Yvonne; Erickson, Johanna Celene; Marini, Pietro; Wilson, Dana; McIntosh, Andrew; Adams, Mark J.; Murgatroyd, Chris; Barrett, Perry; Delibegovic, Mirela; Clarke, Toni-Kim; MacKenzie, Alasdair; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Education; University of Aberdeen.Rowett Institute; University of Aberdeen.Vice Principals; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Molecular and Cellular FunctionItem Disease associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue specific activity of the cannabinoid‐1 receptor gene promoter; implications for cannabinoid pharmacogenetics(2020-01-01) Hay, Elizabeth A; Cowie, Philip; McEwan, Andrew R; Ross, Ruth; Pertwee, Roger G; MacKenzie, Alasdair; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical SciencesItem Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour(2019-11) Hay, Elizabeth A.; McEwan, Andrew; Wilson, Dana; Barrett, Perry; D'Agostino, Giuseppe; Pertwee, Roger G.; MacKenzie, Alasdair; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Rowett Institute; University of Aberdeen.Institute of Applied Health SciencesItem Early and reversible changes to the hippocampal proteome in mice on a high-fat diet(2019-12) McLean, Fiona H.; Campbell, Fiona M.; Sergi, Domenico; Grant, Christine; Morris, Amanda C.; Hay, Elizabeth A.; MacKenzie, Alasdair; Mayer, Claus-D.; Langston, Rosamund F.; Williams, Lynda M.; University of Aberdeen.East Bio; University of Aberdeen.Rowett Institute; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical SciencesItem Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes(2014-12) Richardson, Tom G; Minica, Camelia; Heron, Jon; Tavare, Jeremy; MacKenzie, Alasdair; Day, Ian; Lewis, Glyn; Hickman, Matthew; Vink, Jacqueline M; Gelernter, Joel; Kranzler, Henry R; Farrer, Lindsay A; Munafò, Marcus; Wynick, David; University of Aberdeen.Medical SciencesItem Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones(2011) Shanley, Lynne; Lear, Marissa; Davidson, Scott; Ross, Ruth Alexandra; MacKenzie, Alasdair; University of Aberdeen.Medical SciencesItem Evidence of uneven selective pressure on different subsets of the conserved human genome : implications for the significance of intronic and intergenic DNA(2009-12-16) Davidson, Scott; Starkey, Andrew; MacKenzie, Alasdair; University of Aberdeen.Medical Sciences; University of Aberdeen.Engineering; University of Aberdeen.Centre for Applied Dynamics Research (CADR)Item Exploring the effects of polymorphisms on cis-regulatory signal transduction response(2013-02) MacKenzie, Alasdair; Hing, Benjamin; Davidson, Scott; University of Aberdeen.Medical SciencesItem Exploring the roles of conserved context-dependent cis-regulatory elements (ccdCREs) in multicellularity, human health and disease(2025-07-04) McEwan, Andrew Robert; Rattray, Alexander; Hutchings, Greg; Hay, Elizabeth Anne; Murgatroyd, Chris; MacKenzie, Alasdair; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Molecular and Cellular Function; University of Aberdeen.Institute of Medical SciencesItem Functional effects of polymorphisms on glucocorticoid receptor modulation of human anxiogenic substance-P gene promoter activity in primary amygdala neurones(2014-09) Hay, Colin; Shanley, Lynne; Davidson, Scott; Cowie, Philip; Lear, Marissa; McGuffin, Peter; Riedel, Gernot; McEwan, Iain J; MacKenzie, Alasdair; University of Aberdeen.Medical SciencesItem The human preprotachykinin-A gene promoter has been highly conserved and can drive human-like marker gene expression in the adult mouse CNS.(2000) MacKenzie, Alasdair; University of Aberdeen, Medicine, Medical Sciences & Nutrition, Institute of Medical SciencesItem The human preprotachykinin-A gene promoter has been highly conserved and can drive human-like marker gene expression in the adult mouse CNS.(2000) MacKenzie, Alasdair; University of Aberdeen.Medical SciencesItem Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation(2024-05-07) Leeson-Payne, Alasdair; Iyinikkel, Jean; Malcolm, Cameron; Lam, Brian Y H; Sommer, Nadine; Dowsett, Georgina K C; Blanco Martinez de Morentin, Pablo; Thompson, Dawn; MacKenzie, Alasdair; Chianese, Raffaella; Kentistou, Katherine A; Gardner, Eugene J.; Perry, John R.B.; Grassmann, Felix; Speakman, John; Rochford, Justin; Yeo, Giles S. H.; Murray, Fiona; Heisler, Lora; University of Aberdeen.Rowett Institute; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Cardiometabolic Disease; University of Aberdeen.Aberdeen Cardiovascular and Diabetes Centre; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Molecular and Cellular Function; University of Aberdeen.Environment and Food Security; University of Aberdeen.Energetics Research Group; University of Aberdeen.Biological SciencesItem M3 Receptor Pathway Stimulates Rapid Transcription of the CB1 Receptor Activation through Calcium Signalling and the CNR1 Gene Promoter(2023-01-09) Marini, Pietro; Cowie, Philip; Ayar, Ahmet; Bewick, Guy S; Barrow, John; Pertwee, Roger G; MacKenzie, Alasdair; Tucci, Paolo; University of Aberdeen.Institute of Education in Healthcare and Medical Sciences; University of Aberdeen.Medical Education; University of Aberdeen.Medical Sciences; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Vice Principals; University of Aberdeen.Molecular and Cellular Function