Browsing by Author "McEwan, Iain J."
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Item Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target(2016-05) Asim, Mohammad; Massie, Charles E.; Orafidiya, Folake; Pertega-Gomes, Nelma; Warren, Anne Y.; Esmaeili, Mohsen; Selth, Luke A.; Zecchini, Heather I.; Luko, Katarina; Qureshi, Arham; Baridi, Ajoeb; Menon, Suraj; Madhu, Basetti; Escriu, Carlos; Lyons, Scott; Vowler, Sarah L.; Zecchini, Vincent R.; Shaw, Greg; Hessenkemper, Wiebke; Russell, Roslin; Mohammed, Hisham; Stefanos, Niki; Lynch, Andy G.; Grigorenko, Elena; D'Santos, Clive; Taylor, Chris; Lamb, Alistair; Sriranjan, Rouchelle; Yang, Jiali; Stark, Rory; Dehm, Scott M.; Rennie, Paul S.; Carroll, Jason S.; Griffiths, John R.; Tavare, Simon; Mills, Ian G.; McEwan, Iain J.; Baniahmad, Aria; Tilley, Wayne D.; Neal, David E.; University of Aberdeen.Medical SciencesItem Current and emerging approaches to noncompetitive AR inhibition(2023-09) Riley, Christopher M.; Elwood, Jessica M.L.; Henry, Martyn C.; Hunter, Irene; Daniel Lopez-Fernandez, J.; McEwan, Iain J.; Jamieson, Craig; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical SciencesItem Deciphering the allosteric control of androgen receptor DNA binding by its disordered N-terminal domain(2025-10-01) Heling, Laurens W.H.J.; van der Veen, Jolieke; Rofe, Adam; West, Eric; Jiménez-Panizo, Alba; Alegre-Martí, Andrea; Sheikhhassani, Vahid; Ng, Julian; Schmidt, Thomas; Estébanez-Perpiñá, Eva; McEwan, Iain J.; Mashaghi, Alireza; University of Aberdeen.Medical Sciences; University of Aberdeen.Biological Sciences; University of Aberdeen.Molecular and Cellular FunctionItem EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor(2016-09-16) Moll, Eva De; Fenwick, R. Bryn; Phang, Christopher T.W.; Buzon, Victor; Szulc, Elzbieta; De La Fuente, Alex; Escobedo, Albert; Garcia, Jesus; Bertoncini, Carlos W.; Estebanez-Perpina, Eva; McEwan, Iain J.; Riera, Antoni; Salvatella, Xavier; University of Aberdeen.Medical SciencesItem A New Generation of Selective Androgen Receptor Degraders : Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity(2019) Hwang, Dong-Jin; He, Yali; Ponnusamy, Suriyan; Mohler, Michael L.; Thiyagarajan, Thirumagal; McEwan, Iain J.; Narayanan, Ramesh; Miller, Duane D.; University of Aberdeen.Medical SciencesItem Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer(2017-11) Ponnusamy, Suriyan; Coss, Christopher C.; Thiyagarajan, Thirumagal; Watts, Kate; Hwang, Dong-Jin; He, Yali; Selth, Luke A.; McEwan, Iain J.; Duke, Charles B.; Pagadala, Jayaprakash; Singh, Geetika; Wake, Robert W.; Ledbetter, Christopher; Tilley, Wayne D.; Moldoveanu, Tudor; Dalton, James T.; Miller, Duane D.; Narayanan, Ramesh; University of Aberdeen.Medical SciencesItem Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer(2019-11) Ponnusamy, Suriyan; He, Yali; Hwang, Dong-Jin; Thiyagarajan, Thirumagal; Houtman, Rene; Bocharova, Vera; Sumpter, Bobby G.; Fernandez, Elias; Johnson, Daniel; Du, Ziyun; Pfeffer, Lawrence M.; Getzenberg, Robert H.; McEwan, Iain J.; Miller, Duane D.; Narayanan, Ramesh; University of Aberdeen.Medical SciencesItem Polyglutamine expansion induced dynamic misfolding of androgen receptor(2025-06) Heling, Laurens W.H.J.; Sheikhhassani, Vahid; Ng, Julian; van Vliet, Morris; Jiménez-Panizo, Alba; Alegre-Martí, Andrea; Woodard, Jaie; van Roon-Mom, Willeke; McEwan, Iain J.; Estébanez-Perpiñá, Eva; Mashaghi, Alireza; University of Aberdeen.Medical SciencesItem A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer(2019-09) Warren, Anne Y.; Massie, Charlie E.; Watt, Kate; Luko, Katarina; Orafidiya, Folake; Selth, Luke A.; Mohammed, Hisham; Chohan, Brinder Singh; Menon, Suraj; Baridi, Ajoeb; Zhao, Wanfeng; Escriu, Carlos; D'Santos, Clive; Taylor, Chris; Qureshi, Arham; Zecchini, Vincent R.; Shaw, Greg L.; Dehm, Scott M.; Mills, Ian G.; Carroll, James S.; Tilley, Wayne D.; McEwan, Iain J.; Baniahmad, Aria; Neal, David E.; Asim, Mohammad; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem A sting in the tail : The N-terminal domain of the androgen receptor as a drug target(2016-09) Monaghan, Amy E.; McEwan, Iain J.; University of Aberdeen.Medical SciencesItem Synthesis and Evaluation of Small Molecule Inhibitors of the Androgen Receptor N-Terminal Domain(2023-12-14) Henry, Martyn C.; Riley, Christopher M.; Hunter, Irene; Elwood, Jessica M. L.; Lopez-Fernandez, J. Daniel; Minty, Laura; Coe, Diane M.; McEwan, Iain J.; Jamieson, Craig; University of Aberdeen.Medical Sciences; University of Aberdeen.Molecular and Cellular Function; University of Aberdeen.Aberdeen Cancer Centre; University of Aberdeen.Institute of Medical Sciences