Browsing by Author "Melis, Valeria"
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Item Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1(2011-11-11) Platt, Bettina; Drever, Benjamin; Koss, David; Stoppelkamp, Sandra; Jyoti, Amar; Plano, Andrea; Utan, Aneli; Merrick, Georgina; Ryan, Duncan; Melis, Valeria; Wan, Hong; Mingarelli, Marco; Porcu, Emanuele; Scrocchi, Louise; Welch, Andy; Riedel, Gernot; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Aberdeen Biomedical Imaging CentreItem Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease(2018-02-26) Frahm, Silke; Melis, Valeria; Horsley, David; Rickard, Janet; Riedel, Gernot; Fadda, Paula; Scherma, Maria; Harrington, Charles; Wischik, Claude; Theuring, Franz; Schwab, Karima; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia(2020-12-25) Lemke, Nora; Melis, Valeria; Lauer, Dilyara; Magbagbeolu, Mandy; Neumann, Boris; Harrington, Charles R; Riedel, Gernot; Wischik, Claude M.; Theuring, Franz; Schwab, Karima; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models(2015-06) Melis, Valeria; Magbagbeolu, Mandy; Rickard, Janet E; Horsley, David; Davidson, Kathleen; Harrington, Kathleen A; Goatman, Keith; Goatman, Elizabeth A; Deiana, Serena; Close, Steve P; Zabke, Claudia; Stamer, Karsten; Dietze, Silke; Schwab, Karima; Storey, John M D; Harrington, Charles R; Wischik, Claude M; Theuring, Franz; Riedel, Gernot; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Epidemiology Group; University of Aberdeen.Chemistry; University of Aberdeen.Medical SciencesItem High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease(2024-10-02) Arastoo, Mohammad; Penny, Lewis Kirk; Lofthouse, Richard Andrew; Abdallah, Aya; Abrahamsson, Anna; Marini, Pietro; Melis, Valeria; Riedel, Gernot; Harrington, Charles; Wischik, Claude; Porter, Andrew; Palliyil, Soumya; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Medical Education; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Microbiology and ImmunityItem HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine(2022-04-07) Santos, Renato X.; Melis, Valeria; Goatman, Elizabeth A.; Leith, Michael; Baddeley, Thomas C.; Storey, John M.D.; Riedel, Gernot; Wischik, Claude M.; Harrington, Charles R.; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Chemistry; University of Aberdeen.NeuroscienceItem Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain(2025-05) Coelho Dos Santos, Renato; Lee, Sophie H; Lofthouse, Richard Andrew; Melis, Valeria; Strachan, Lianne; Leith, Michael; Dreesen, Eline; Armstrong, Paul; Vorley, Thomas; Goatman, Elizabeth; Hull, Claire; Riedel, Gernot; Wischik, Claude; Harrington, Charles; University of Aberdeen.Medical Sciences; University of Aberdeen.Chemistry; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical SciencesItem LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy(2024-05-05) Schwab, Karima; Frahm, Silke; Magbagbeolu, Mandy; Horsley, David; Goatman, Elizabeth; Melis, Valeria; Theuring, Franz; Ishaq, Ahtsham; Storey, John M. D.; Harrington, Charles; Wischik, Claude; Riedel, Gernot; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Chemistry; University of Aberdeen.NeuroscienceItem Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model(2020-03-31) Riedel, Gernot; Klein, Jochen; Niewiadomska, Grazyna; Kondak, Constantin; Schwab, Karima; Lauer, Dilyara; Magbagbeolu, Mandy; Steczkowska, Marta; Zadrozny, Maciej; Wydrych, Malgorzata; Cranston, Anna; Melis, Valeria; Santos, Renato X.; Theuring, Franz; Harrington, Charles R.; Wischik, Claude M.; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Applied MedicineItem A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy(2018-01-10) Schwab, Karima; Frahm, Silke; Horsley, David; Rickard, Janet E; Melis, Valeria; Goatman, Elizabeth A; Magbagbeolu, Mandy; Douglas, Morag; Leith, Michael G; Baddeley, Thomas C.; Storey, John M D; Riedel, Gernot; Wischik, Claude M; Harrington, Charles R; Theuring, Franz; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.ChemistryItem Proteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks(2021-08-22) Schwab, Karima; Melis, Valeria; Harrington, Charles R.; Wischik, Claude M.; Magbagbeolu, Mandy; Theuring, Franz; Riedel, Gernot; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.NeuroscienceItem Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia(2025-01) Schwab, Karima; Strachan, Lianne; Anschuetz, Anne; Dreesen, Eline Stefanie; Magbagbeolu, Mandy; Melis, Valeria; Theuring, Franz; Harrington, Charles; Wischik, Claude; Riedel, Gernot; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical Sciences