Browsing by Author "Pickard, Robert"

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Ablative therapy for people with localised prostate cancer : a systematic review and economic evaluation
(2015-07-01) Ramsay, Craig R; Adewuyi, Temitope E; Gray, Joanne; Hislop, Jenni; Shirley, Mark Df; Jayakody, Shalmini; MacLennan, Graeme; Fraser, Cynthia; MacLennan, Sara; Brazzelli, Miriam; N'Dow, James; Pickard, Robert; Robertson, Clare; Rothnie, Kieran; Rushton, Stephen P; Vale, Luke; Lam, Thomas B; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Academic Urology Unit
Alternative approaches to endoscopic ablation for benign enlargement of the prostate : a systematic review of randomised controlled trials
(BMJ, 2008) Lourenco, Tania; Pickard, Robert; Vale, Luke David; Grant, Adrian Maxwell; Fraser, Cynthia Mary; MacLennan, Graeme Stewart; N'Dow, James Michael Olu; Benign Prostatic Enlargement Team; University of Aberdeen, School of Medicine & Dentistry, Division of Applied Health Sciences
Objective To compare the effectiveness and risk profile of newer methods for endoscopic ablation of the prostate against the current standard of transurethral resection. Design Systematic review and meta-analysis. Data sources Electronic and paper records in subject area up to March 2006. Review methods We searched for randomised controlled trials of endoscopic ablative interventions that included transurethral resection of prostate as one of the treatment arms. Two reviewers independently extracted data and assessed quality. Meta-analyses of prespecified outcomes were done using fixed and random effects models and reported using relative risk or weighted mean difference. Results We identified 45 randomised controlled trials meeting the inclusion criteria and reporting on 3970 participants. The reports were of moderate to poor quality, with small sample sizes. None of the newer technologies resulted in significantly greater improvement in symptoms than transurethral resection at 12 months, although a trend suggested a better outcome with holmium laser enucleation (random effects weighted mean difference -0.82, 95% confidence interval 1.76 to 0.12) and worse outcome with laser vaporisation (1.49, -0.40 to 3.39). Improvements in secondary measures, such as peak urine flow rate, were consistent with change in symptoms. Blood transfusion rates were higher for transurethral resection than for the newer methods (4.8% v 0.7%) and men undergoing laser vaporisation or diathermy vaporisation were more likely to experience urinary retention (6.7% v 2.3% and 3.6% v 1.1%). Hospital stay was up to one day shorter for the newer technologies. Conclusions Although men undergoing more modern methods of removing benign prostatic enlargement have similar outcomes to standard transurethral resection of prostate along with fewer requirements for blood transfusion and shorter hospital stay, the quality of current evidence is poor. The lack of any clearly more effective procedure suggests that transurethral resection should remain the standard approach.
Antibiotic treatment for intermittent bladder catheterisation with once daily prophylaxis (the AnTIC study) : Study protocol for a randomised controlled trial
(2016-06-04) Brennand, Catherine; von Wilamowitz-Moellendorff, Alexander; Dunn, Sarah; Wilkinson, Jennifer; Chadwick, Thomas; Ternent, Laura; Oluboyede, Yemi; Wood, Ruth; Walton, Katherine; Fader, Mandy; N'Dow, James; Abdel-Fattah, Mohamed; McClurg, Doreen; Little, Paul; Hilton, Paul; Timoney, Anthony; Morris, Nicola; Thiruchelvam, Nikesh; Larcombe, James; Harrison, Simon; Armstrong, Heather; McColl, Elaine; Pickard, Robert; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Academic Urology Unit; University of Aberdeen.Institute of Applied Health Sciences
Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital : a multicentre randomised controlled trial
(2012-12-01) Pickard, Robert; Lam, Thomas; Maclennan, Graeme; Starr, Kath; Kilonzo, Mary; McPherson, Gladys; Gillies, Katie; McDonald, Alison; Walton, Katherine; Buckley, Brian; Glazener, Cathryn; Boachie, Charles; Burr, Jennifer; Norrie, John; Vale, Luke; Grant, Adrian; N'Dow, James; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Academic Urology Unit; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Health Economics Research Unit; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Applied Medicine
Bowel dysfunction after transposition of intestinal segments into the urinary tract : 8-year prospective cohort study
(Elsevier, 2007) Somani, Bhaskar K.; Kumar, Vinod; Wong, Susan; Pickard, Robert; Ramsay, Craig R; Nabi, Ghulam; Grant, Adrian Maxwell; N'Dow, James Michael Olu; ABACUS Research Group
Purpose Bowel function may be disturbed after intestinal segments are transposed into the urinary tract to reconstruct or replace the bladder. In 1997, our group were the first to report major bowel dysfunction in a cohort of such patients: up to 42% of those who were asymptomatic preoperatively describing new bowel symptoms postoperatively including explosive diarrhoea, nocturnal diarrhoea, faecal urgency, faecal incontinence and flatus leakage . We now describe bowel symptoms in this same cohort eight years later (2005). Materials and Methods 116 patients were evaluable. Of the remaining 37 from the original report: 30 had died, five no longer wished to be involved, and two could not be traced. Patients were asked to complete postal questionnaires identical to those used in the first follow-up, assessing the severity of bowel symptoms and quality of life using two validated instruments. Responses were compared with those from the original study. The Nottingham Health Profile quality of life scores were also compared to age and sex matched norms. Results 96 (83%) completed eight-year follow-up questionnaires: 43 after ileal conduit diversion (Group 1), 17 after clam enterocystoplasty for overactive bladder (Group 2), 18 after reconstructed bladder for neurogenic bladder dysfunction (Group 3), and 18 with bladder replacement for non-neurogenic causes (Group 4). High prevalence rates of bowel symptoms persisted with no statistically significant differences between the two time points. Of those with symptoms in 2005, around 50% had reported similar symptoms in 1997. Clam enterocystoplasty patients (Group 2) still reported the highest prevalence (59%) of troublesome diarrhoea with one in two on regular anti-diarrhoeal medication. They also had high rates of faecal incontinence (47%), faecal urgency (41%) and nocturnal bowel movement (18%); with high proportions reporting a moderate or severe adverse effect on work (36%), social life (50%) and sex life (43%). High rates were also reported by neurogenic bladder dysfunction patients, including 50% with troublesome diarrhoea. This symptom was reported by 19% after ileal conduit and by 17% after bladder replacement for non-neurogenic causes. The impact of bowel symptoms on every-day activities and quality of life persisted, remaining most severe after clam enterocystoplasty, with 24% regretting undergoing the procedure because of subsequent bowel symptoms. Conclusions: After more than eight years, operations involving transposition of intestinal segments continue to be associated with high rates of bowel symptoms, which impact on everyday activities. These are particularly troublesome following enterocystoplasty for overactive bladder and bladder reconstruction for neurogenic bladder dysfunction. These risks should influence patient selection and potential patients should be warned prior to surgery.
The clinical and cost effectiveness of surgical interventions for stones in the lower pole of the kidney : the percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole kidney stones randomised controlled trial (PUrE RCT) protocol
(2020-06-04) McClinton, Sam; Starr, Kathryn; Thomas, Ruth; MacLennan, Graeme; Lam, Thomas; Hernandez, Rodolfo; Pickard, Robert; Anson, Ken; Clark, Terry; MacLennan, Steven; Thomas, David; Smith, Daron; Turney, Ben; McDonald, Alison; Cameron, Sarah; Wiseman, Oliver; University of Aberdeen.Applied Medicine; University of Aberdeen.Academic Urology Unit; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Centre for Healthcare Randomised Trials (CHaRT); University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Health Economics Research Unit
The clinical effectiveness of transurethral incision of the prostate : a systematic review of randomised controlled trials
(2010-02) Lourenco, Tania; Shaw, Matthew; Fraser, Cynthia Mary; MacLennan, Graeme Stewart; N'Dow, James Michael Olu; Pickard, Robert; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Academic Urology Unit; University of Aberdeen.Institute of Applied Health Sciences
Comparative Cost-effectiveness of Robot-assisted and Standard Laparoscopic Prostatectomy as Alternatives to Open Radical Prostatectomy for Treatment of Men with Localised Prostate Cancer : A Health Technology Assessment from the Perspective of the UK National Health Service
(2013-09) Close, Andrew; Robertson, Clare; Rushton, Stephen; Shirley, Mark; Vale, Luke; Ramsay, Craig; Pickard, Robert; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health Sciences
Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC) : a randomised, open-label trial
(2018-09-01) Fisher, Holly; Oluboyede, Yemi; Chadwick, Thomas; Abdel-Fattah, Mohamed; Brennand, Catherine; Fader, Mandy; Harrison, Simon; Hilton, Paul; Larcombe, James; Little, Paul; McClurg, Doreen; McColl, Elaine; N'Dow, James; Ternent, Laura; Thiruchelvam, Nikesh; Timoney, Anthony; Vale, Luke; Walton, Katherine; von Wilamowitz-Moellendorff, Alexander; Wilkinson, Jennifer; Wood, Ruth; Pickard, Robert; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Academic Urology Unit
Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation : the AnTIC RCT
(2018-05-31) Pickard, Robert; Chadwick, Thomas; Oluboyede, Yemi; Brennand, Catherine; von Wilamowitz-Moellendorff, Alexander; McClurg, Doreen; Wilkinson, Jennifer; Ternent, Laura; Fisher, Holly; Walton, Katherine; McColl, Elaine; Vale, Luke; Wood, Ruth; Abdel-Fattah, Mohamed; Hilton, Paul; Fader, Mandy; Harrison, Simon; Larcombe, James; Little, Paul; Timoney, Anthony; N'Dow, James; Armstrong, Heather; Morris, Nicola; Walker, Kerry; Thiruchelvam, Nikesh; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Academic Urology Unit
Male synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER) : Study protocol for a randomised controlled trial
(2018-02-21) Constable, Lynda; Cotterill, Nikki; Cooper, David; Glazener, Cathryn; Drake, Marcus J.; Forrest, Mark; Harding, Chris; Kilonzo, Mary; MacLennan, Graeme; McCormack, Kirsty; McDonald, Alison; Mundy, Anthony; Norrie, John; Pickard, Robert; Ramsay, Craig; Smith, Rebecca; Wileman, Samantha; Abrams, Paul; The MASTER Study Group; University of Aberdeen.University of Aberdeen; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Physical Sciences; University of Aberdeen.Health Economics Research Unit; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences
Medical expulsive therapy in adults with ureteric colic : a multicentre, randomised, placebo-controlled trial
(2015-07-25) Pickard, Robert; Starr, Kathryn; MacLennan, Graeme; Lam, Thomas Boon Leong; Thomas, Ruth; Burr, Jennifer; McPherson, Gladys; McDonald, Alison; Anson, Kenneth; N'Dow, James; Burgess, Neil; Clark, Terry; Kilonzo, Mary; Gillies, Kate; Shearer, Kirsty; Boachie, Charles; Cameron, Sarah; Norrie, John; McClinton, Samuel; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Academic Urology Unit; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Health Economics Research Unit
Minimally invasive therapies for the treatment of benign prostatic enlargement : systematic review of randomised controlled trials
(BMJ, 2008-10-09) Lourenco, Tania; Pickard, Robert; Vale, Luke David; Grant, Adrian Maxwell; Fraser, Cynthia Mary; MacLennan, Graeme Stewart; N'Dow, James Michael Olu; University of Aberdeen, School of Medicine & Dentistry, Division of Applied Health Sciences
Objective: To compare the effectiveness and risk profile of minimally invasive interventions against the current standard of transurethral resection of the prostate. Design Systematic review and meta-analysis of randomised controlled trials. Data sources Electronic and paper records up to March 2006. Review methods: We searched for all relevant randomised controlled trials. Two reviewers independently extracted data and assessed quality. Meta-analyses of prespecified outcomes were performed with fixed and random effects models and reported using relative risks or weighted mean difference. Results 3794 abstracts were identified; 22 randomised controlled trials met the inclusion criteria. These provided data on 2434 participants. The studies evaluated were of moderate to poor quality with small sample sizes. Minimally invasive interventions were less effective than transurethral resection of the prostate in terms of improvement in symptom scores and increase in urine flow rate, with most comparisons showing significance despite wide confidence intervals. Rates of second operation were significantly higher for minimally invasive treatments. The risk profile of minimally invasive interventions was better than that of transurethral resection, with fewer adverse events. The results, however, showed significant heterogeneity. Conclusion: Which minimally invasive intervention is the most promising remains unclear. Their place in the management of benign prostate enlargement will continue to remain controversial until well designed and well reported randomised controlled trials following CONSORT guidelines prove they are superior and more cost effective than drug treatment or that strategies of sequential surgical treatments are preferred by patients and are more cost effective than the more invasive but more effective tissue ablative interventions such as transurethral resection.
Open urethroplasty versus endoscopic urethrotomy - clarifying the management of men with recurrent urethral stricture (the OPEN trial) : study protocol for a randomised controlled trial
(2015-12-30) Stephenson, Rachel; Carnell, Sonya; Johnson, Nicola; Brown, Robbie; Wilkinson, Jennifer; Mundy, Anthony; Payne, Steven; Watkin, Nick; N'Dow, James; Sinclair, Andrew; Rees, Rowland; Barclay, Stewart; Cook, Jonathan A; Goulao, Beatriz; MacLennan, Graeme; McPherson, Gladys; Jackson, Matthew; Rapley, Tim; Shen, Jing; Vale, Luke; Norrie, John; McColl, Elaine; Pickard, Robert; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Academic Urology Unit; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Aberdeen Centre for Evaluation
Photodynamic versus white light-guided treatment of non-muscle invasive bladder cancer : A study protocol for a randomised trial of clinical and cost-effectiveness
(2019-09-03) Tandogdu, Zafer; Lewis, Rebecca; Duncan, Anne; Penegar, Steven; McDonald, Alison; Vale, Luke; Shen, Jing; Kelly, John D.; Pickard, Robert; N Dow, James; Ramsay, Craig; Mostafid, Hugh; Mariappan, Paramananthan; Nabi, Ghulam; Creswell, Joanne; Lazarowicz, Henry; McGrath, John; Taylor, Ernest; Clark, Emma; Maclennan, Graeme; Norrie, John; Hall, Emma; Heer, Rakesh; University of Aberdeen.Centre for Healthcare Randomised Trials (CHaRT); University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences
Relative effectiveness of robot-assisted and standard laparoscopic prostatectomy as alternatives to open radical prostatectomy for treatment of localised prostate cancer : a systematic review and mixed treatment comparison meta-analysis
(2013-10) Robertson, Clare; Close, Andrew; Fraser, Cynthia; Gurung, Tara; Jia, Xueli; Sharma, Pawana; Vale, Luke; Ramsay, Craig; Pickard, Robert; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health Sciences
Surgical Treatment for Recurrent Bulbar Urethral Stricture : A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial)
(2020-10) Goulao, Beatriz; Carnell, Sonya; Shen, Jing; MacLennan, Graeme; Norrie, John; Cook, Jonathan; McColl, Elaine; Breckons, Matthew; Vale, Luke; Whybrow, Paul; Rapley, Tim; Forbes, Rebecca; Currer, Stephanie; Forrest, Mark; Wilkinson, Jennifer; Andrich, Daniela; Barclay, Stewart; Mundy, Anthony; N'Dow, James; Payne, Stephen; Watkin, Nick; Pickard, Robert; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Academic Urology Unit
Surgical treatments for men with benign prostatic enlargement : cost effectiveness study
(2009-04-16) Armstrong, Nigel; Vale, Luke; Deverill, Mark; Nabi, Ghulam; McClinton, Samuel; N'Dow, James; Pickard, Robert; BPE Study Group; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Academic Urology Unit; University of Aberdeen.Institute of Applied Health Sciences
TISU: Extracorporeal shockwave lithotripsy, as first treatment option, compared with direct progression to ureteroscopic treatment, for ureteric stones : study protocol for a randomised controlled trial
(2018-05-22) McClinton, Samuel; Cameron, Sarah; Starr, Kathryn; Thomas, Ruth; MacLennan, Graeme; McDonald, Alison; Lam, Thomas; N’Dow, James; Kilonzo, Mary; Pickard, Robert; Anson, Ken; Burgess, Neil; Clark, Charles Terry; MacLennan, Sara; Norrie, John; TISU Study Group; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Academic Urology Unit; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Health Economics Research Unit
Use of drug therapy in the management of symptomatic ureteric stones in hospitalised adults : a multicentre, placebo-controlled, randomised controlled trial and cost-effectiveness analysis of a calcium channel blocker (nifedipine) and an alpha-blocker (tamsulosin) (the SUSPEND trial)
(2015-08-01) Pickard, Robert; Starr, Kathryn; MacLennan, Graeme; Kilonzo, Mary; Lam, Thomas; Thomas, Ruth Elizabeth; Burr, Jennifer; Norrie, John; McPherson, Gladys; McDonald, Alison; Shearer, Kirsty; Gillies, Katie; Anson, Kenneth; Boachie, Charles; N'Dow, James; Burgess, Neil; Clark, Terry; Cameron, Sarah; McClinton, Samuel; University of Aberdeen.Academic Urology Unit; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Health Economics Research Unit; University of Aberdeen.Medicine, Medical Sciences & Nutrition