Browsing by Author "Zwarenstein, Merrick"
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Item Comments, Suggestions and Criticisms of the PRECIS-2 Design Tool : A Citation Analysis(2024-12) Willis, Andrew; Shiely, Frances; Treweek, Shaun; Taljaard, Monica; Loudon, Kirsty; Howie, Alison; Zwarenstein, Merrick; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health SciencesItem Consensus Statement for Protocols of Factorial Randomized Trials : Extension of the SPIRIT 2013 Statement(2023-12-05) Kahan, Brennan C.; Hall, Sophie S.; Beller, Elaine M.; Birchenall, Megan; Elbourne, Diana; Juszczak, Edmund; Little, Paul; Fletcher, John; Golub, Robert M.; Goulao, Beatriz; Hopewell, Sally; Islam, Nazrul; Zwarenstein, Merrick; Chan, An-Wen; Montgomery, Alan A.; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Centre for Healthcare Randomised Trials (CHaRT)Item CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE) : checklist with explanation and elaboration(2021-04-29) Kwakkenbos, Linda; Imran, Mahrukh; McCall, Stephen J; McCord, Kimberly A; Fröbert, Ole; Hemkens, Lars G; Zwarenstein, Merrick; Relton, Clare; Rice, Danielle B; Langan, Sinéad M; Benchimol, Eric I; Thabane, Lehana; Campbell, Marion K; Sampson, Margaret; Erlinge, David; Verkooijen, Helena M; Moher, David; Boutron, Isabelle; Ravaud, Philippe; Nicholl, Jon; Uher, Rudolf; Sauvé, Maureen; Fletcher, John; Torgerson, David; Gale, Chris; Juszczak, Edmund; Thombs, Brett D; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Vice Principals; University of Aberdeen.Institute of Applied Health SciencesItem Developing a framework for the ethical design and conduct of pragmatic trials in healthcare : a mixed methods research protocol(2018-09-27) Taljaard, Monica; Weijer, Charles; Grimshaw, Jeremy M; Ali, Adnan; Brehaut, Jamie C; Campbell, Marion K; Carroll, Kelly; Edwards, Sarah; Eldridge, Sandra; Forrest, Christopher B; Giraudeau, Bruno; Goldstein, Cory E; Graham, Ian D; Hemming, Karla; Hey, Spencer Phillips; Horn, Austin R; Jairath, Vipul; Klassen, Terry P; London, Alex John; Marlin, Susan; Marshall, John C; McIntyre, Lauralyn; McKenzie, Joanne E; Nicholls, Stuart G; Alison Paprica, P; Zwarenstein, Merrick; Fergusson, Dean A; University of Aberdeen.Vice Principals; University of Aberdeen.Institute of Applied Health SciencesItem Feedback GAP : study protocol for a cluster-randomized trial of goal setting and action plans to increase the effectiveness of audit and feedback interventions in primary care(2010-12-17) Ivers, Noah M; Tu, Karen; Francis, Jill; Barnsley, Jan; Shah, Baiju; Upshur, Ross; Kiss, Alex; Grimshaw, Jeremy M; Zwarenstein, Merrick; University of Aberdeen.Other Applied Health SciencesItem Guidance for protocol content and reporting of factorial randomised trials : explanation and elaboration of the CONSORT 2010 and SPIRIT 2013 extensions(2025-02) Kahan, Brennan C; Juszczak, Edmund; Beller, Elaine; Birchenall, Megan; Chan, An-Wen; Hall, Sophie; Little, Paul; Fletcher, John; Golub, Robert M; Goulao, Beatriz; Hopewell, Sally; Islam, Nazrul; Zwarenstein, Merrick; Elbourne, Diana R.; Montgomery , Alan; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Centre for Healthcare Randomised Trials (CHaRT)Item The importance of decision intent within descriptions of pragmatic trials(2020-09) Nicholls, Stuart G.; Zwarenstein, Merrick; Hey, Spencer P.; Giraudeau, Bruno; Campbell, Marion K.; Taljaard, Monica; University of Aberdeen.Vice Principals; University of Aberdeen.Institute of Applied Health SciencesItem Looking inside the black box : a theory-based process evaluation alongside a randomised controlled trial of printed educational materials (the Ontario printed educational message, OPEM) to improve referral and prescribing practices in primary care in Ontario, Canada(BioMed Central, 2007-11-26) Grimshaw, Jeremy; Zwarenstein, Merrick; Tetroe, Jacqueline; Godin, Gaston; Graham, Ian D.; Lemyre, Louise; Eccles, Martin P.; Johnston, Marie; Francis, Jillian Joy; Hux, Jan; O'Rourke, Keith; Legare, France; Presseau, JustinBackground: Randomised controlled trials of implementation strategies tell us whether (or not) an intervention results in changes in professional behaviour but little about the causal mechanisms that produce any change. Theory-based process evaluations collect data on theoretical constructs alongside randomised trials to explore possible causal mechanisms and effect modifiers. This is similar to measuring intermediate endpoints in clinical trials to further understand the biological basis of any observed effects (for example, measuring lipid profiles alongside trials of lipid lowering drugs where the primary endpoint could be reduction in vascular related deaths). This study protocol describes a theory-based process evaluation alongside the Ontario Printed Educational Message (OPEM) trial. We hypothesize that the OPEM interventions are most likely to operate through changes in physicians' behavioural intentions due to improved attitudes or subjective norms with little or no change in perceived behavioural control. We will test this hypothesis using a well-validated social cognition model, the theory of planned behaviour (TPB) that incorporates these constructs. Methods/design: We will develop theory-based surveys using standard methods based upon the TPB for the second and third replications, and survey a subsample of Ontario family physicians from each arm of the trial two months before and six months after the dissemination of the index edition of informed, the evidence based newsletter used for the interventions. In the third replication, our study will converge with the "TRY-ME" protocol (a second study conducted alongside the OPEM trial), in which the content of educational messages was constructed using both standard methods and methods informed by psychological theory. We will modify Dillman's total design method to maximise response rates. Preliminary analyses will initially assess the internal reliability of the measures and use regression to explore the relationships between predictor and dependent variable (intention to advise diabetic patients to have annual retinopathy screening and to prescribe thiazide diuretics for first line treatment of uncomplicated hypertension). We will then compare groups using methods appropriate for comparing independent samples to determine whether there have been changes in the predicted constructs (attitudes, subjective norms, or intentions) across the study groups as hypothesised, and will assess the convergence between the process evaluation results and the main trial results.Item Looking inside the black box : results of a theory-based process evaluation exploring the results of a randomized controlled trial of printed educational messages to increase primary care physicians' diabetic retinopathy referrals [Trial registration number ISRCTN72772651](2014-08-06) Grimshaw, Jeremy M; Presseau, Justin; Tetroe, Jacqueline; Eccles, Martin P; Francis, Jill J; Godin, Gaston; Graham, Ian D; Hux, Janet E; Johnston, Marie; Légaré, France; Lemyre, Louise; Robinson, Nicole; Zwarenstein, Merrick; University of Aberdeen.Registry; University of Aberdeen.Other Applied Health SciencesItem Making clinical trials more relevant : improving and validating the PRECIS tool for matching trial design decisions to trial purpose(2013-04-27) Loudon, Kirsty; Zwarenstein, Merrick; Sullivan, Frank; Donnan, Peter; Treweek, Shaun; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health SciencesItem Methods and results used in the development of a consensus-driven extension to the Consolidated Standards of Reporting Trials (CONSORT) statement for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE)(2021-04-29) Imran, Mahrukh; Kwakkenbos, Linda; McCall, Stephen J; McCord, Kimberly A; Fröbert, Ole; Hemkens, Lars G; Zwarenstein, Merrick; Relton, Clare; Rice, Danielle B; Langan, Sinéad M; Benchimol, Eric I; Thabane, Lehana; Campbell, Marion K; Sampson, Margaret; Erlinge, David; Verkooijen, Helena M; Moher, David; Boutron, Isabelle; Ravaud, Philippe; Nicholl, Jon; Uher, Rudolf; Sauvé, Maureen; Fletcher, John; Torgerson, David; Gale, Chris; Juszczak, Edmund; Thombs, Brett D; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Vice Principals; University of Aberdeen.Institute of Applied Health SciencesItem PRECIS-2 for retrospective assessment of RCTs in systematic reviews : some thoughts on intention, dichotomization and applicability of RCTs(2020-10-01) Zwarenstein, Merrick; Thorpe, Kevin; Treweek, Shaun; Loudon, Kirsty; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health SciencesItem PRECIS-2 helps researchers design more applicable RCTs while CONSORT Extension for Pragmatic Trials helps knowledge users decide whether to apply them(2017-04) Zwarenstein, Merrick; Treweek, Shaun; Loudon, Kirsty; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health SciencesItem The PRECIS-2 tool : designing trials that are fit for purpose(2015-05-08) Loudon, Kirsty; Treweek, Shaun; Sullivan, Frank; Donnan, Peter; Thorpe, Kevin E; Zwarenstein, Merrick; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health SciencesItem The PRECIS-2 tool has good inter-rater reliability and modest discriminant validity(2017-08) Loudon, Kirsty; Zwarenstein, Merrick; Sullivan, Frank; Donnan, Peter; Gágyor, Ildikó; Hobbelen, Hans; Althabe, Fernando; Krishnan, Jerry A; Treweek, Shaun; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health SciencesItem Printed educational messages fail to increase use of thiazides as first-line medication for hypertension in primary care : a cluster randomized controlled trial [ISRCTN72772651](2016-09-17) Zwarenstein, Merrick; Grimshaw, Jeremy M; Presseau, Justin; Francis, Jill J; Godin, Gaston; Johnston, Marie; Eccles, Martin P; Tetroe, Jacqueline; Shiller, Susan K; Croxford, Ruth; Kelsall, Diane; Paterson, J Michael; Austin, Peter C; Tu, Karen; Yun, Lingsong; Hux, Janet E; University of Aberdeen.Other Applied Health SciencesItem Protocol for a scoping review to support development of a CONSORT extension for randomised controlled trials using cohorts and routinely collected health data(2018-08-05) Kwakkenbos, Linda; Imran, Mahrukh; McCord, Kimberly A; Sampson, Margaret; Fröbert, Ole; Gale, Chris; Hemkens, Lars G; Langan, Sinead M; Moher, David; Relton, Clare; Zwarenstein, Merrick; Benchimol, Eric I; Boutron, Isabelle; Campbell, Marion K; Erlinge, David; Jawad, Sena; Ravaud, Philippe; Rice, Danielle B; Sauve, Maureen; van Staa, Tjeerd P; Thabane, Lehana; Uher, Rudolf; Verkooijen, Helena M; Juszczak, Edmund; Thombs, Brett D; University of Aberdeen.Vice Principals; University of Aberdeen.Institute of Applied Health SciencesItem Protocol for the development of a CONSORT extension for RCTs using cohorts and routinely collected health data(2018-10-29) Kwakkenbos, Linda; Juszczak, Edmund; Hemkens, Lars G; Sampson, Margaret; Fröbert, Ole; Relton, Clare; Gale, Chris; Zwarenstein, Merrick; Langan, Sinéad M; Moher, David; Boutron, Isabelle; Ravaud, Philippe; Campbell, Marion K; Mc Cord, Kimberly A; van Staa, Tjeerd P; Thabane, Lehana; Uher, Rudolf; Verkooijen, Helena M; Benchimol, Eric I; Erlinge, David; Sauvé, Maureen; Torgerson, David; Thombs, Brett D; University of Aberdeen.Vice Principals; University of Aberdeen.Institute of Applied Health SciencesItem Randomised trials conducted using cohorts : a scoping review(2024-03-08) Nickolls, Beverley Jane; Relton, Clare; Hemkens, Lars; Zwarenstein, Merrick; Eldridge, Sandra; McCall, Stephen J; Griffin, Xavier Luke; Sohanpal, Ratna; Verkooijen, Helena M; Maguire, Jonathon L; McCord, Kimberly A; University of Aberdeen.Aberdeen Centre for Women’s Health Research; University of Aberdeen.Other Applied Health SciencesItem Rating of Included Trials on the Efficacy-Effectiveness Spectrum : development of a new tool for systematic reviews(2017-04) Wieland, L. Susan; Berman, Brian M.; Altman, Douglas G.; Barth, Jürgen; Bouter, Lex M.; D’Adamo, Christopher R.; Linde, Klaus; Moher, David; Mullins, Daniel; Treweek, Shaun; Tunis, Sean; van der Windt, Danielle A.; Zwarenstein, Merrick; Witt, Claudia; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health Sciences