2 - Schools incorporating the Life Sciences and Medicine
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Item The Effects of Graded Levels of Calorie Restriction : XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice(2019-01-01) Green, Cara L; Soltow, Quinlyn A; Mitchell, Sharon E; Derous, Davina; Wang, Yingchun; Chen, Luonan; Han, Jing-Dong J; Promislow, Daniel E. L.; Lusseau, David; Douglas, Alexander; Jones, Dean P; Speakman, John R.; University of Aberdeen.East Bio; University of Aberdeen.Biological Sciences; University of Aberdeen.Energetics Research Group; University of Aberdeen.Marine Alliance for Science and Technology for Scotland (MASTS); University of Aberdeen.Energy; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Medical Statistics; University of Aberdeen.Environment and Food SecurityItem Explaining age differences in working memory : The role of updating, inhibition, and shifting(2019-06) Zuber, Sascha; Ihle, Andreas; Loaiza, Vanessa M.; Schnitzspahn, Katharina; Stahl, Christoph; Phillips, Louise H; Kaller, Christoph P; Kliegel, Matthias; University of Aberdeen.PsychologyItem The effects of graded levels of calorie restriction : VII. Topological rearrangement of hypothalamic aging networks(2016-04-23) Derous, Davina; Mitchell, Sharon E.; Green, Cara L.; Wang, Yingchun; Chen, Luonan; Promislow, Daniel E L; Lusseau, David; Speakman, John R.; Douglas, Alex; University of Aberdeen.Biological Sciences; University of Aberdeen.Energetics Research Group; University of Aberdeen.East Bio; University of Aberdeen.University of Aberdeen; University of Aberdeen.Biological Sciences; University of Aberdeen.Marine Alliance for Science and Technology for Scotland (MASTS); University of Aberdeen.Energy; University of Aberdeen.Environment and Food Security; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Medical StatisticsItem The interplay of intention maintenance and cue monitoring in younger and older adults' prospective memory(2017-10) Ballhausen, Nicola; Schnitzspahn, Katharina M.; Horn, Sebastian S.; Kliegel, Matthias; University of Aberdeen.PsychologyItem The impact of aging on the neural networks involved in gaze and emotional processing(2016-12) Ziaei, Maryam; Burianová, Hana; von Hippel, William; Ebner, Natalie C; Phillips, Louise H; Henry, Julie D; University of Aberdeen.PsychologyItem CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction(2016-04) Lipina, Christopher; Vaanholt, Lobke M.; Davidova, Anastasija; Mitchell, Sharon E.; Storey-Gordon, Emma; Hambly, Catherine; Irving, Andrew J.; Speakman, John R.; Hundal, Harinder S.; University of Aberdeen.Biological Sciences; University of Aberdeen.Energetics Research Group; University of Aberdeen.Environment and Food SecurityItem Nature or nurture; BMI and blood pressure at 90. Findings from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)(2009-12) Rea, I Maeve; Myint, Phyo K; Mueller, Heiko; Murphy, Anne; Archbold, G Pooler R; McNulty, Helene; Patterson, Chris C; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Applications Management; University of Aberdeen.Institute of Applied Health SciencesItem Age-related changes in matching novel objects across viewpoints(2011-09) Pilz, Karin S; Konar, Yaroslav; Vuong, Quoc C; Bennett, Patrick J; Sekuler, Alison B; University of Aberdeen.PsychologyItem Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over : a randomised controlled trial(BMC, 2007-05-02) McNeil, Geraldine; Avenell, Alison; Campbell, Marion Kay; Cook, Jonathan Alistair; Hannaford, Philip Christopher; Kilonzo, Mary Mueni; Milne, Anne Catherine; Ramsay, Craig R; Seymour, David Gwyn; Stephen, Audrey Isabella; Vale, Luke David; MAVIS Trial Group; University of Aberdeen, School of Medicine & Dentistry, Division of Applied Health SciencesBackground: Observational studies have frequently reported an association between cognitive function and nutrition in later life but randomised trials of B vitamins and antioxidant supplements have mostly found no beneficial effect. We examined the effect of daily supplementation with 11 vitamins and 5 minerals on cognitive function in older adults to assess the possibility that this could help to prevent cognitive decline. Methods: The study was carried out as part of a randomised double blind placebo controlled trial of micronutrient supplementation based in six primary care health centres in North East Scotland. 910 men and women aged 65 years and over living in the community were recruited and randomised: 456 to active treatment and 454 to placebo. The active treatment consisted of a single tablet containing eleven vitamins and five minerals in amounts ranging from 50–210 % of the UK Reference Nutrient Intake or matching placebo tablet taken daily for 12 months. Digit span forward and verbal fluency tests, which assess immediate memory and executive functioning respectively, were conducted at the start and end of the intervention period. Risk of micronutrient deficiency at baseline was assessed by a simple risk questionnaire. Results: For digit span forward there was no evidence of an effect of supplements in all participants or in sub-groups defined by age or risk of deficiency. For verbal fluency there was no evidence of a beneficial effect in the whole study population but there was weak evidence for a beneficial effect of supplementation in the two pre-specified subgroups: in those aged 75 years and over (n 290; mean difference between supplemented and placebo groups 2.8 (95% CI -0.6, 6.2) units) and in those at increased risk of micronutrient deficiency assessed by the risk questionnaire (n 260; mean difference between supplemented and placebo groups 2.5 (95% CI -1.0, 6.1) units). Conclusion: The results provide no evidence for a beneficial effect of daily multivitamin and multimineral supplements on these domains of cognitive function in community-living people over 65 years. However, the possibility of beneficial effects in older people and those at greater risk of nutritional deficiency deserves further attention.