2 - Schools incorporating the Life Sciences and Medicine
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Item A randomised controlled trial of calcium channel blockade (CCB) with Amlodipine For the treatment oF subcortical ischaEmic vasCular demenTia (AFFECT) : study protocol(2016-07-18) Greenan, Caroline; Murphy, Lynn; Yu, Ly-Mee; Kehoe, Patrick G; Coulthard, Elizabeth; Bath, Philip; Stewart, Robert; Jones, Rob; Corbett, Anne; Thomas, Alan; Connelly, Peter; Arrojo, Frank; Canning, Rachel; Wallach, Sylvia; Henderson, Catherine; McGuinness, Bernadette; O'Sullivan, Mike; Holmes, Clive; Knapp, Martin; Ballard, Clive; Passmore, Peter; AFFECT Investigators; Soiza, Roy; University of Aberdeen.Aberdeen Centre for EvaluationItem Effect of intermittent pneumatic compression on disability, living circumstances, quality of life, and hospital costs after stroke : secondary analyses from CLOTS 3, a randomised trial(2014-12) Myint, Phyo Kyaw; CLOTS (Clots in Legs Or sTockings after Stroke) Trials Collaboration; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health SciencesItem Measuring the psychosocial burden in women with low-grade abnormal cervical cytology in the TOMBOLA trial : psychometric properties of the Process and Outcome Specific Measure (POSM)(2014-11-12) Rothnie, Kieran; Cotton, Seonaidh Claire; Fielding, Shona; Gray, Nicola M; Little, Julian; Cruickshank, Margaret E; Walker, Leslie G; Avis, Mark; Sharp, Linda; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Medical EducationItem Microwave endometrial ablation versus thermal balloon endometrial ablation (MEATBall) : 5-year follow up of a randomised controlled trial(2014-05) Sambrook, A M; Elders, A; Cooper, K G; University of Aberdeen.Other Applied Health SciencesItem British randomised controlled trial of AV and VV optimization ("BRAVO") study : rationale, design, and endpoints(2014-04-03) Whinnett, Zachary I; Sohaib, S M Afzal; Jones, Siana; Kyriacou, Andreas; March, Katherine; Coady, Emma; Mayet, Jamil; Hughes, Alun D; Frenneaux, Michael; Francis, Darrel P; BRAVO Investigators; University of Aberdeen.Applied MedicineItem Body mass index, occupational activity, and leisure-time physical activity : an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort(2013) Martin, Kathryn R; Kuh, Diana; Harris, Tamara B; Guralnik, Jack M; Coggon, David; Wills, Andrew K; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Epidemiology Group; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)Item Impact of night-time symptoms in COPD : a real-world study in five European countries(2013-11-27) Price, David; Small, Mark; Milligan, Gary; Higgins, Victoria; Gil, Esther Garcia; Estruch, Jordi; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health SciencesItem Clinical and cost effectiveness of mobile phone supported self monitoring of asthma : multicentre randomised controlled trial(2012-03-23) Ryan, Dermot; Price, David; Musgrave, Stan D.; Malhotra, Shweta; Lee, Amanda J.; Ayansina, Dolapo; Sheikh, Aziz; Tarassenko, Lionel; Pagliari, Claudia; Pinnock, Hilary; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Medical StatisticsItem The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE) : study protocol for a randomized controlled trial(2011-05-23) Azuara-Blanco, Augusto; Burr, Jennifer M; Cochran, Claire; Ramsay, Craig; Vale, Luke; Foster, Paul; Friedman, David; Quayyum, Zahidul; Lai, Jimmy; Nolan, Winnie; Aung, Tin; Chew, Paul; McPherson, Gladys; McDonald, Alison; Norrie, John David Taylor; Effectiveness in Angle-closure Glaucoma of Lens Extraction (EAGLE) Study Group; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health SciencesItem The Knee Arthroplasty Trial (KAT) : design features, baseline characteristics and two-year functional outcomes after alternative approaches to knee replacement(Wiley, 2009-01-01) Campbell, Marion Kay; Fiddian, Nick; Fitzpatrick, Ray; Grant, Adrian Maxwell; Gray, Alastair; Morris, Richard; Murray, David; Rowley, David; Johnston, Linda; MacLennan, Graeme Stewart; McCormack, Kirsty; Ramsay, Craig R; Walker, Allan; KAT Trial Group; University of Aberdeen, School of Medicine & Dentistry, Division of Applied Health SciencesBackground: The aim of continued development of total knee replacement systems has been the further improvement of the quality of life and increasing the duration of prosthetic survival. Our goal was to evaluate the effects of several design features, including metal backing of the tibial component, patellar resurfacing, and a mobile bearing between the tibial and femoral components, on the function and survival of the implant. Methods: A pragmatic, multicenter, randomized, controlled trial involving 116 surgeons in thirty-four centers in the United Kingdom was performed; 2352 participants were randomly allocated to be treated with or without a metal backing of the tibial component (409), with or without patellar resurfacing (1715), and/or with or without a mobile bearing (539). Randomization to more than one comparison was allowed. The primary outcome measures were the Oxford Knee Score (OKS), Short Form-12, EuroQol-5D, and the need for additional surgery. The results up to two years postoperatively are reported. Results: Functional status and quality-of-life scores were low at baseline but improved markedly across all trial groups following knee replacement (mean overall OKS, 17.98 points at baseline and 34.82 points at two years). Most of the change was observed at three months after the surgery. Six percent of the patients had additional knee surgery within two years. There was no evidence of differences in clinical, functional, or quality-of-life measures between the randomized groups at two years. Conclusions: Patients have substantial improvement following total knee replacement. This is the first adequately powered randomized controlled trial, of which we are aware, in which the effects of metal backing, patellar resurfacing, and a mobile bearing were investigated. We found no evidence of an effect of these variants on the rate of early complications or on functional recovery up to two years after total knee replacement. Level of Evidence: Therapeutic Level I. See Instructions to Authors for a complete description of levels of evidence.