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Item Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis : a Systematic Review and Meta-Analysis of Preclinical Research(2020-05-25) Elliott, Elizabeth; Bailey, Olivia; Waldron, Fergal M.; Hardingham, Giles E.; Chandran, Siddharthan; Gregory, Jenna M.; University of Aberdeen.Medical SciencesItem Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis : a systematic review and meta-analysis(2019-08-06) Mehta, Arpan R.; Walters, Rachel; Waldron, Fergal M.; Pal, Suvankar; Selvaraj, Bhuvaneish T.; Macleod, Malcolm R.; Hardingham, Giles E.; Chandran, Siddharthan; Gregory, Jenna; University of Aberdeen.Medical SciencesItem Random forest modelling of neuropathological features identifies microglial activation as an accurate pathological classifier of C9orf72-related amyotrophic lateral sclerosis(bioRxiv, 2021-12-10) Rifai, Olivia M.; Longden, James; O’Shaughnessy, Judi; Sewell, Michael D.E.; McDade, Karina; Daniels, Michael J.D.; Abrahams, Sharon; Chandran, Siddharthan; McColl, Barry; Sibley, Christopher R.; Gregory, Jenna M.; University of Aberdeen.Medical Sciences; University of Aberdeen.NeuroscienceItem Neuronal clusterin expression is associated with cognitive protection in amyotrophic lateral sclerosis(2020-05-18) Gregory, J. M.; Elliott, E.; McDade, K.; Bak, T.; Pal, Suvankar; Chandran, Siddharthan; Abrahams, Sharon; Smith, C.; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical SciencesItem Improved detection of RNA foci in C9orf72 amyotrophic lateral sclerosis post-mortem tissue using BaseScope™ shows a lack of association with cognitive dysfunction(2020-01) Mehta, Arpan R.; Barton, Samantha K.; McDade, Karina; Abrahams, Sharon; Chandran, Siddharthan; Smith, Colin; Gregory, Jenna; University of Aberdeen.Medical SciencesItem Executive, language and fluency dysfunction are markers of localised TDP-43 cerebral pathology in non-demented ALS(2020-02) Gregory, Jenna; McDade, Karina; Bak, Thomas H; Pal, Suvankar; Chandran, Siddharthan; Smith, Colin; Abrahams, Sharon; University of Aberdeen.Medical SciencesItem Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?(2019-05-21) Barton, Samantha Kate; Gregory, Jenna; Chandran, Siddharthan; Turner , Bradley J; University of Aberdeen.Medical SciencesItem A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease(MedRxiv, 2022-04-22) Wong, Charis; Gregory, Jenna; Liao, Jing; Egan, Kieren; Vesterinen, Hanna M.; Khan, Aimal Ahmad; Anwar, Maarij; Beagan, Caitlin; Brown, Fraser; Cafferkey, John; Cardinali, Alessandra; Chiam, Jane Yi; Chiang, Claire; Collins, Victoria; Dormido, Joyce; Elliott, Elizabeth; Foley, Peter; Foo, Yu Cheng; Fulton-Humble, Lily; Gane, Angus B.; Glasmacher, Stella; Heffernan, Áine; Jayaprakash, Kiran; Jayasuriya, Nimesh; Kaddouri, Amina; Kiernan, Jamie; Langlands, Gavin; Leighton, Danielle; Liu, Jiaming; Lyon, James; Mehta, Arpan R.; Meng, Alyssa; Nguyen, Vivienne; Park, Kyu Hyung; Quigley, Suzanne; Rashid, Yousuf; Salzinger, Andrea; Shiell, Bethany; Singh, Ankur; Soane, Tim; Thompson, Alexandra; Tomala, Olaf; Waldron, Fergal M.; Selvaraj, Bhuvaneish T.; Chataway, Jeremy; Swingler, Robert; Connick, Peter; Pal, Suvankar; Chandran, Siddharthan; Macleod, Malcolm R.; University of Aberdeen.Neuroscience; University of Aberdeen.Medical SciencesItem Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology(2022-01-10) Jiwaji, Zoeb; Tiwari, Sachin S.; Avilés-Reyes, Rolando X.; Hooley, Monique; Hampton, David; Torvell, Megan; Johnson, Delinda A.; McQueen, Jamie; Baxter, Paul; Sabari-Sankar, Kayalvizhi; Qiu, Jing; He, Xin; Fowler, Jill; Febery, James; Gregory, Jenna; Rose, Jamie; Tulloch, Jane; Loan, Jamie; Story, David; McDade, Karina; Smith, Amy M.; Greer, Peta; Ball, Matthew; Kind, Peter C.; Matthews, Paul M.; Smith, Colin; Dando, Owen; Spires-Jones, Tara L.; Johnson, Jeffrey A.; Chandran, Siddharthan; Hardingham, Giles E.Item Probing TDP-43 condensation using an in silico designed aptamer(2022-06-23) Zacco, Elsa; Kantelberg, Owen; Milanetti, Edoardo; Armaos, Alexandros; Panei, Francesco Paolo; Gregory, Jenna; Jeacock, Kiani; Clarke, David J.; Chandran, Siddharthan; Ruocco, Giancarlo; Gustincich, Stefano; Horrocks, Mathew; Pastore, Annalisa; Tartaglia, Gian Gaetano; University of Aberdeen.Medical Sciences; University of Aberdeen.Neuroscience