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Item Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine(2022) Kondak, Constantin; Riedel, Gernot; Harrington, Charles R; Wischik, Claude M; Klein, Jochen; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem The Neurovascular Unit Dysfunction in Alzheimer's Disease(2021-02-18) Soto-Rojas, Luis O; Pacheco-Herrero, Mar; Martínez-Gómez, Paola A; Campa-Córdoba, B Berenice; Apátiga-Pérez, Ricardo; Villegas-Rojas, Marcos M; Harrington, Charles R; de la Cruz, Fidel; Garcés-Ramírez, Linda; Luna-Muñoz, José; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical SciencesItem Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease(2020-11-26) Arastoo, Mohammad; Lofthouse, Richard; Penny, Lewis; Harrington, Charles R; Porter, Andy; Wischik, Claude M; Palliyil, Soumya; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration(2020-03-30) Cranston, Anna L; Wysocka, Adrianna; Steczkowska, Marta; Zadrozny, Maciej; Palasz, Ewelina; Harrington, Charles R; Theuring, Franz; Wischik, Claude; Riedel, Gernot; Niewiadomska, Grazyna; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain(2020-03-01) Al-Hilaly, Youssra K; Foster, Bronwen E; Biasetti, Luca; Lutter, Liisa; Pollack, Saskia J; Rickard, Janet E; Storey, John M D; Harrington, Charles R; Xue, Wei-Feng; Wischik, Claude M; Serpell, Louise C; University of Aberdeen.Applied Medicine; University of Aberdeen.Chemistry; University of Aberdeen.Medical SciencesItem Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development(2018-03-13) Wischik, Claude M; Schelter, Björn O; Wischik, Damon J; Storey, John M D; Harrington, Charles R; University of Aberdeen.Applied Medicine; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Chemistry; University of Aberdeen.Medical SciencesItem Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease : Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial(2017-11-28) Wilcock, Gordon K; Gauthier, Serge; Frisoni, Giovanni B; Jia, Jianping; Hardlund, Jiri H; Moebius, Hans J; Bentham, Peter; Kook, Karin A; Schelter, Bjoern Olaf; Wischik, Damon J; Davis, Charles S; Staff, Roger T; Vuksanovic, Vesna; Ahearn, Trevor; Bracoud, Luc; Shamsi, Kohkan; Marek, Ken; Seibyl, John; Riedel, Gernot; Storey, John M. D.; Harrington, Charles R; Wischik, Claude M; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Aberdeen Biomedical Imaging Centre; University of Aberdeen.Chemistry