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Item Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model(2024-04-06) Zadrozny, Maciej; Drapich, Patrycja; Gasiorowska-Bien, Anna; Niewiadomski, Wiktor; Harrington, Charles R; Wischik, Claude M; Riedel, Gernot; Niewiadomska, Grazyna; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Applied MedicineItem Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice(2023-06-28) Kondak, Constantin; Leith, Michael; Baddeley, Thomas C; Santos, Renato X; Harrington, Charles R; Wischik, Claude M; Riedel, Gernot; Klein, Jochen; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Chemistry; University of Aberdeen.Medical Sciences; University of Aberdeen.Neuroscience; University of Aberdeen.Applied MedicineItem Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine(2022) Kondak, Constantin; Riedel, Gernot; Harrington, Charles R; Wischik, Claude M; Klein, Jochen; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem The Neurovascular Unit Dysfunction in Alzheimer's Disease(2021-02-18) Soto-Rojas, Luis O; Pacheco-Herrero, Mar; Martínez-Gómez, Paola A; Campa-Córdoba, B Berenice; Apátiga-Pérez, Ricardo; Villegas-Rojas, Marcos M; Harrington, Charles R; de la Cruz, Fidel; Garcés-Ramírez, Linda; Luna-Muñoz, José; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical SciencesItem Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease(2020-11-26) Arastoo, Mohammad; Lofthouse, Richard; Penny, Lewis; Harrington, Charles R; Porter, Andy; Wischik, Claude M; Palliyil, Soumya; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Tau Filament Self-Assembly and Structure : Tau as a Therapeutic Target.(2020-11-12) Oakley, Sebastian; Maina, Mahmoud B.; Marshall, Karen E.; Al-Hilaly, Youssra K; Harrington, Charles R; Wischik, Claude M; Serpell, Louise C; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer’s Disease(2020-09-10) Luna-Viramontes, Nabil Itzi; Campa-Córdoba, B. Berenice; Ontiveros-Torres, Miguel Angel; Harrington, Charles R; Villanueva-Fierro, Ignacio; Guadarrama-Ortíz, Parménides; Garcés-Ramírez, Linda; de la Cruz, Fidel; Hernandes-Alejandro, Mario; Martínez-Robles, Sandra; González-Ballesteros, Erik; Pacheco-Herrero, Mar; Luna-Muñoz, José; University of Aberdeen.Medical SciencesItem Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration(2020-03-30) Cranston, Anna L; Wysocka, Adrianna; Steczkowska, Marta; Zadrozny, Maciej; Palasz, Ewelina; Harrington, Charles R; Theuring, Franz; Wischik, Claude; Riedel, Gernot; Niewiadomska, Grazyna; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking(2017-11-24) Al-Hilaly, Youssra K; Pollack, Saskia J; Vadukul, Devkee; Citossi, Francesca; Rickard, Janet E; Simpson, Michael; Storey, John M D; Harrington, Charles R; Wischik, Claude M; Serpell, Louise C; University of Aberdeen.Applied Medicine; University of Aberdeen.Chemistry; University of Aberdeen.Medical SciencesItem Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease : a randomised, controlled, double-blind, parallel-arm, phase 3 trial(2016-12) Gauthier, Serge; Feldman, Howard H; Schneider, Lon S; Wilcock, Gordon K; Frisoni, Giovanni B; Hardlund, Jiri H; Moebius, Hans J; Bentham, Peter; Kook, Karin A; Wischik, Damon J; Schelter, Bjoern O; Davis, Charles S; Staff, Roger T; Bracoud, Luc; Shamsi, Kohkan; Storey, John M D; Harrington, Charles R; Wischik, Claude M; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Medical Sciences; University of Aberdeen.Chemistry; University of Aberdeen.Applied Medicine