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Item Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain(2025-05) Coelho Dos Santos, Renato; Lee, Sophie H; Lofthouse, Richard Andrew; Melis, Valeria; Strachan, Lianne; Leith, Michael; Dreesen, Eline; Armstrong, Paul; Vorley, Thomas; Goatman, Elizabeth; Hull, Claire; Riedel, Gernot; Wischik, Claude; Harrington, Charles; University of Aberdeen.Medical Sciences; University of Aberdeen.Chemistry; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical SciencesItem Pharmacological PTP1B inhibition rescues motor learning, neuroinflammation, and hyperglycaemia in a mouse model of Alzheimer’s Disease(2025-03) Franklin, Zara; Hull, Claire; Delibegovic, Mirela; Platt, Bettina; University of Aberdeen.Medical Education; University of Aberdeen.Medical Sciences; University of Aberdeen.Cardiometabolic Disease; University of Aberdeen.Aberdeen Cardiovascular and Diabetes Centre; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.NeuroscienceItem The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice(2021-07-01) Dekeryte, Ruta; Franklin, Zara; Hull, Claire; Croce, Lorenzo; Kamli-Salino, Sarah; Helk, Oliver Walter; Hoffmann, Philip; Yang, Zhixiang; Riedel, Gernot; Delibegovic, Mirela; Platt, Bettina; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Neuroscience; University of Aberdeen.Vice Principals; University of Aberdeen.Medical Sciences - Cardiovascular GroupItem NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia(2020-12-01) Hull, Claire; Dekeryte, Ruta; Buchanan, Heather; Kamli-Salino, Sarah; Robertson, Avril; Delibegovic, Mirela; Platt, Bettina; University of Aberdeen.Medical Sciences; University of Aberdeen.Medical Sciences - Cardiovascular GroupItem Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice(2019-08-01) Dekeryte, Ruta; Hull, Claire; Plucinska, Kaja; Khan, Shakil; Kamli-Salino, Sarah; Mody, Nimesh; Morrice, Nicola; McLaughlin, Chris; Gault, Victor; Platt, Bettina; Delibegovic, Mirela; University of Aberdeen.Aberdeen Cardiovascular and Diabetes Centre; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Medical Sciences - Cardiovascular GroupItem Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia(2020-01) Hull, Claire; Dekeryte, Ruta; Koss, David J.; Crouch, Barry; Buchanan, Heather; Delibegovic, Mirela; Platt, Bettina; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Medical Sciences; University of Aberdeen.Biological Sciences; University of Aberdeen.Medical Sciences - Cardiovascular GroupItem Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer’s disease(2018-11-15) Koss, David J.; Dubini, Marina; Buchanan, Heather; Hull, Claire; Platt, Bettina; University of Aberdeen.Medical Sciences; University of Aberdeen.Biological Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition