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Item An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans(2024-03-01) McEwan, Andrew Robert; Hing, Benjamin; Erickson, Johanna C.; Hutchings, Greg; Urama, Charity; Norton-Hughes, Emily; D'Ippolito, Mariam; Berry, Susan; Delibegovic, Mirela; Grassmann, Felix; MacKenzie, Alasdair; University of Aberdeen.Medical Sciences; University of Aberdeen.Molecular and Cellular Function; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Applied MedicineItem Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities(2022-06) MacKenzie, Alasdair; Hay, Elizabeth A; McEwan, Andrew R; University of Aberdeen.Molecular and Cellular Function; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Institute of Medical SciencesItem The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet(2021-03) McEwan, Andrew; Erickson, Johanna Celene; Davidson, Connor; Heijkoop, Jenny; Turnbull, Yvonne; Delibegovic, Mirela; Murgatroyd , Christopher; MacKenzie, Alasdair; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medical Sciences; University of Aberdeen.Vice Principals; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Molecular and Cellular FunctionItem CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake(2019-12-13) Mcewan, Andrew; Hay, Elisabeth; Davidson, Connor; Turnbull, Yvonne; Erickson, Johanna Celene; Marini, Pietro; Wilson, Dana; McIntosh, Andrew M.; Adams, Mark J.; Murgatroyd, Chris; Barrett, Perry; Delibegovic, Mirela; Clarke, Toni-Kim; MacKenzie, Alasdair; University of Aberdeen.Medical Education; University of Aberdeen.Rowett Institute; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Medical SciencesItem Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective?(2020-10-23) McEwan, Andrew R; MacKenzie, Alasdair; University of Aberdeen.Medical SciencesItem CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake(2021-06) McEwan, Andrew R; Davidson, Connor; Hay, Elizabeth; Turnbull, Yvonne; Erickson, Johanna Celene; Marini, Pietro; Wilson, Dana; McIntosh, Andrew; Adams, Mark J.; Murgatroyd, Chris; Barrett, Perry; Delibegovic, Mirela; Clarke, Toni-Kim; MacKenzie, Alasdair; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Education; University of Aberdeen.Rowett Institute; University of Aberdeen.Vice Principals; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Molecular and Cellular FunctionItem Disease associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue specific activity of the cannabinoid‐1 receptor gene promoter; implications for cannabinoid pharmacogenetics(2020-01-01) Hay, Elizabeth A; Cowie, Philip; McEwan, Andrew R; Ross, Ruth; Pertwee, Roger G; MacKenzie, Alasdair; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical SciencesItem Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour(2019-11) Hay, Elizabeth A.; McEwan, Andrew; Wilson, Dana; Barrett, Perry; D'Agostino, Giuseppe; Pertwee, Roger G.; MacKenzie, Alasdair; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Rowett Institute; University of Aberdeen.Institute of Applied Health Sciences