5 - All research
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Item An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans(2024-03-01) McEwan, Andrew Robert; Hing, Benjamin; Erickson, Johanna C.; Hutchings, Greg; Urama, Charity; Norton-Hughes, Emily; D'Ippolito, Mariam; Berry, Susan; Delibegovic, Mirela; Grassmann, Felix; MacKenzie, Alasdair; University of Aberdeen.Medical Sciences; University of Aberdeen.Molecular and Cellular Function; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Applied MedicineItem CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake(2019-12-13) Mcewan, Andrew; Hay, Elisabeth; Davidson, Connor; Turnbull, Yvonne; Erickson, Johanna Celene; Marini, Pietro; Wilson, Dana; McIntosh, Andrew M.; Adams, Mark J.; Murgatroyd, Chris; Barrett, Perry; Delibegovic, Mirela; Clarke, Toni-Kim; MacKenzie, Alasdair; University of Aberdeen.Medical Education; University of Aberdeen.Rowett Institute; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Medical SciencesItem Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective?(2020-10-23) McEwan, Andrew R; MacKenzie, Alasdair; University of Aberdeen.Medical SciencesItem CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake(2021-06) McEwan, Andrew R; Davidson, Connor; Hay, Elizabeth; Turnbull, Yvonne; Erickson, Johanna Celene; Marini, Pietro; Wilson, Dana; McIntosh, Andrew; Adams, Mark J.; Murgatroyd, Chris; Barrett, Perry; Delibegovic, Mirela; Clarke, Toni-Kim; MacKenzie, Alasdair; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Education; University of Aberdeen.Rowett Institute; University of Aberdeen.Vice Principals; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Molecular and Cellular FunctionItem Early and reversible changes to the hippocampal proteome in mice on a high-fat diet(2019-12) McLean, Fiona H.; Campbell, Fiona M.; Sergi, Domenico; Grant, Christine; Morris, Amanda C.; Hay, Elizabeth A.; MacKenzie, Alasdair; Mayer, Claus-D.; Langston, Rosamund F.; Williams, Lynda M.; University of Aberdeen.East Bio; University of Aberdeen.Rowett Institute; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical SciencesItem Using the CRISPR/Cas9 system to understand neuropeptide biology and regulation(2017-08) Hay, Elizabeth A; Knowles, Christopher; Kolb, Andreas; MacKenzie, Alasdair; University of Aberdeen.Medical Sciences; University of Aberdeen.Rowett InstituteItem An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome(2017-08) Hay, Elizabeth Anne; Khalaf, Abdulla Razak; Marini, Pietro; Brown, Andrew; Heath, Karyn; Sheppard, Darrin; MacKenzie, Alasdair; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Medical Education; University of Aberdeen.Biological SciencesItem Exploring the effects of polymorphisms on cis-regulatory signal transduction response(2013-02) MacKenzie, Alasdair; Hing, Benjamin; Davidson, Scott; University of Aberdeen.Medical SciencesItem An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells(2015-10-08) Hay, Colin W; Hunter, Irene; MacKenzie, Alasdair; McEwan, Iain J; University of Aberdeen.Biological Sciences; University of Aberdeen.Medical SciencesItem Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes(2014-12) Richardson, Tom G; Minica, Camelia; Heron, Jon; Tavare, Jeremy; MacKenzie, Alasdair; Day, Ian; Lewis, Glyn; Hickman, Matthew; Vink, Jacqueline M; Gelernter, Joel; Kranzler, Henry R; Farrer, Lindsay A; Munafò, Marcus; Wynick, David; University of Aberdeen.Medical Sciences