5 - All research
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Item Pharmacological PTP1B inhibition rescues motor learning, neuroinflammation, and hyperglycaemia in a mouse model of Alzheimer’s Disease(2025-03) Franklin, Zara; Hull, Claire; Delibegovic, Mirela; Platt, Bettina; University of Aberdeen.Medical Education; University of Aberdeen.Medical Sciences; University of Aberdeen.Cardiometabolic Disease; University of Aberdeen.Aberdeen Cardiovascular and Diabetes Centre; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.NeuroscienceItem Effects of age and dietary methionine restriction on cognitive and behavioural phenotypes in the rTg4510 mouse model of frontotemporal dementia(2025-02) Souza Matos, Marina; Sil, Annesha; Riedel, Gernot; Platt, Bettina; Delibegovic, Mirela; University of Aberdeen.Medical Sciences; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Cardiometabolic Disease; University of Aberdeen.Aberdeen Cardiovascular and Diabetes Centre; University of Aberdeen.Medical Sciences - Cardiovascular GroupItem The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice(2021-07-01) Dekeryte, Ruta; Franklin, Zara; Hull, Claire; Croce, Lorenzo; Kamli-Salino, Sarah; Helk, Oliver Walter; Hoffmann, Philip; Yang, Zhixiang; Riedel, Gernot; Delibegovic, Mirela; Platt, Bettina; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Neuroscience; University of Aberdeen.Vice Principals; University of Aberdeen.Medical Sciences - Cardiovascular GroupItem Sex Differences in Behavior and Molecular Pathology in the 5XFAD Model(2022-01-18) Sil, Annesha; Erfani, Arina; Lamb, Nicola; Copland, Rachel; Platt, Bettina; Riedel, Gernot; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.NeuroscienceItem NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia(2020-12-01) Hull, Claire; Dekeryte, Ruta; Buchanan, Heather; Kamli-Salino, Sarah; Robertson, Avril; Delibegovic, Mirela; Platt, Bettina; University of Aberdeen.Medical Sciences; University of Aberdeen.Medical Sciences - Cardiovascular GroupItem Effects of dietary restriction on metabolic and cognitive health(2021-05) Delibegovic, Mirela; Souza Matos, Marina; Platt, Bettina; University of Aberdeen.Vice Principals; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.NeuroscienceItem Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease(2020-08-31) Dey, Madhurima; Gunn-Moore, Frank J; Platt, Bettina; Smith, Terry K; University of Aberdeen.Medical SciencesItem Synaptic Loss, ER Stress and Neuro-inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease(2020-08) Buchanan, Heather; Mackay, Murray; Palmer, Kerri; Tothová, Karolína; Katsur, Miroslava; Platt, Bettina; Koss, David J.; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Medical SciencesItem Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice(2019-08-01) Dekeryte, Ruta; Hull, Claire; Plucinska, Kaja; Khan, Shakil; Kamli-Salino, Sarah; Mody, Nimesh; Morrice, Nicola; McLaughlin, Chris; Gault, Victor; Platt, Bettina; Delibegovic, Mirela; University of Aberdeen.Aberdeen Cardiovascular and Diabetes Centre; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Medical Sciences - Cardiovascular GroupItem Decay in Retinoic Acid Signaling in Varied Models of Alzheimer’s Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes(2020-02-04) Khatib, Thabat; Chisholm, David R; Whiting, Andrew; Platt, Bettina; McCaffery, Peter; University of Aberdeen.Medical Sciences
