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Item Oral Tau Aggregation Inhibitor for Alzheimer’s Disease : Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate(2022-10) Wischik, Claude M.; Bentham, P.; Gauthier, S.; Miller, S.; Kook, K.; Schelter, B. O.; University of Aberdeen.Neuroscience; University of Aberdeen.Applied Medicine; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.PhysicsItem Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model : Effects of hydromethylthionine(2022-09-01) Schwab, Karima; Chasapopoulou, Zoi; Frahm, Silke; Magbagbeolu, Mandy; Cranston, Anna; Harrington, Charles R.; Wischik, Claude M.; Theuring, Franz; Riedel, Gernot; University of Aberdeen.Applied Medicine; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Neuroscience; University of Aberdeen.Medical Sciences; University of Aberdeen.Institute of Medical SciencesItem Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis(2022-04-15) Lutter, Liisa; Al-Hilaly, Youssra K.; Serpell, Christopher J.; Tuite, Mick F.; Wischik, Claude M.; Serpell, Louise C.; Xue, Wei Feng; University of Aberdeen.Neuroscience; University of Aberdeen.Applied Medicine; University of Aberdeen.Institute of Medical SciencesItem Long-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier(2021-09-28) Bentham, Peter; Staff, Roger T.; Schelter, Bjoern O.; Shiells, Helen; Harrington, Charles R.; Wischik, Claude M.; University of Aberdeen.Medical Sciences; University of Aberdeen.Centre for Health Data Science; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Physics; University of Aberdeen.Neuroscience; University of Aberdeen.Institute of Medical Sciences; University of Aberdeen.Applied MedicineItem Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia(2020-12-25) Lemke, Nora; Melis, Valeria; Lauer, Dilyara; Magbagbeolu, Mandy; Neumann, Boris; Harrington, Charles R; Riedel, Gernot; Wischik, Claude M.; Theuring, Franz; Schwab, Karima; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia(2020-05-19) Shiells, Helen; Schelter, Bjoern O.; Bentham, Peter; Baddeley, Thomas C.; Rubino, Christopher M.; Ganesan, Harish; Hammel, Jeffrey; Vuksanovic, Vesna; Staff, Roger T.; Murray, Alison D.; Bracoud, Luc; Wischik, Damon J.; Riedel, Gernot; Gauthier, Serge; Jia, Jianping; Moebius, Hans J.; Hardlund, Jiri; Kipps, Christopher M.; Kook, Karin; Storey, John M. D.; Harrington, Charles R.; Wischik, Claude M.; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Chemistry; University of Aberdeen.Applied Medicine; University of Aberdeen.Centre for Health Data Science; University of Aberdeen.Medical Sciences; University of Aberdeen.Grampian Data Safe Haven (DaSH); University of Aberdeen.Aberdeen Biomedical Imaging CentreItem Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells : A Morphological Study(2019-09-17) Flores-Rodríguez, Paola; Harrington, Charles R.; Wischik, Claude M.; Ibarra-Bracamontes, Vanessa; Zarco, Natanael; Navarrete, Araceli; Martínez-Maldonado, Alejandra; Guadarrama-Ortíz, Parménides; Villanueva-Fierro, Ignacio; Ontiveros-Torres, Miguel Angel; Perry, George; Alonso, Alejandra D.; Florán-Garduño, Benjamin; Segovia, José; Luna-Muñoz, José; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine