5 - All research
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Item Risk of Bowel Obstruction in Patients Undergoing Neoadjuvant Chemotherapy for High-risk Colon Cancer : A Nested Case-control-matched Analysis of an International, Multicenter, Randomized Controlled Trial (FOxTROT)(2024-08-01) FOxTROT Collaborating Group; Glasbey, James; University of Aberdeen.Other Applied Health SciencesItem Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer : a study protocol of a randomised phase II trial (PRIME-RT)(2021-08-26) Hanna, Catherine R.; O’Cathail, Sean M.; Graham, Janet S.; Saunders, Mark; Samuel, Leslie; Harrison, Mark; Devlin, Lynsey; Edwards, Joanne; Gaya, Daniel R.; Kelly, Caroline A.; Lewsley, Liz-Anne; Maka, Noori; Morrison, Paula; Dinnett, Louise; Dillon, Susan; Gourlay, Jacqueline; Platt, Jonathan J.; Thomson, Fiona; Adams, Richard A.; Roxburgh, Campbell S. D.; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Medical EducationItem Mathematical model of brain tumour growth with drug resistance(2021-12-01) Trobia, José; Tian, Kun; Batista, Antonio Marcos; Grebogi, Celso; Ren, Hai-Peng; Santos, Moises Souza; Protachevicz, Paulo Ricardo; Borges, Fernando da Silva; Jr, José Danilo Szezech; Viana, Ricardo Luiz; Caldas, Iberê Luiz; Iarosz, Kelly Cristiane; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Natural & Computing SciencesItem Effects of drug resistance in the tumour-immune system with chemotherapy treatment(2020) Trobia, José; Gabrick, Enrique C.; Seifert, Evandro G.; Borges, Fernando S.; Protachevicz, Paulo Ricardo; Szezech Jr, Jose D.; Iarosz, Kelly C.; Santos, Moises S.; Caldas, Iberê L.; Tian, Kun; Ren, Hai Peng; Grebogi, Celso; Batista, Antonio M.; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB)Item Tumour chemotherapy strategy based on impulse control theory(2017-03-06) Ren, Hai-Peng; Yang, Yan; Baptista, M. S.; Grebogi, Celso; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Physics; University of Aberdeen.EnergyItem Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat(2017-11-01) Galley, Helen F; McCormick, Barry; Wilson, Kirsten L.; Lowes, Damon A.; Colvin, Lesley; Torsney, Carole; University of Aberdeen.Applied MedicineItem Mathematical model of brain tumour with glia-neuron interactions and chemotherapy treatment(2015-03-07) Iarosz, Kelly C.; Borges, Fernando S.; Batista, Antonio M.; Baptista, M. S.; Siqueira, Regiane A. N.; Viana, Ricardo L.; Lopes, Sergio R.; Baptista, M. S.; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Physics; University of Aberdeen.EnergyItem Model for tumour growth with treatment by continuous and pulsed chemotherapy(2014-02) Borges, F. S.; Iarosz, K. C.; Ren, H. P.; Batista, A. M.; Baptista, M. S.; Viana, R. L.; Lopes, S. R.; Grebogi, C.; University of Aberdeen.Physics; University of Aberdeen.Energy; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Environment and Food SecurityItem Influence of chemoresistance and p53 status on fluoro-2-deoxy-D-glucose incorporation in cancer(2010-01) Smith, Tim A D; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical SciencesItem Symposium 4: Hot topics on parenteral nutrition. A review of the use of glutamine supplementation in the nutritional support of patients undergoing bone-marrow transplantation and traditional cancer therapy(Cambridge University Press, 2009) Crowther, MarkThe relationship between glutamine and malignancy can be traced back to the 1950s and the requirement for glutamine for malignant-cell growth in culture. Later studies demonstrated an association between the rate of proliferation of the malignant cells and glutamine usage. The excessive use of glutamine by malignant cells was seen as an opportunity for the development of a treatment using glutamine analogues, but unfortunately excessive toxicity was observed during clinical studies. In animal models glutamine supplementation, initially thought to increase tumour growth, actually causes tumour regression as a result of improved immune clearance of the tumour and appears to reduce the severity of the side effects of chemo- and radiotherapy. This finding led to human studies in both traditional cancer therapy and bone-marrow transplantation, which are reviewed here. Unfortunately, the majority of the studies performed are small and have poor methodological reporting. There is clinical heterogeneity in terms of routes of administration, dosing schedules, chemotherapy regimens and diseases. Studies of glutamine in non-bone-marrow transplantation chemo- and/or radiotherapy treatment suggest a possible trend towards reductions in objective mucositis but no effect on subjective symptoms. There is no evidence for its effect on other clinical outcomes. For bone-marrow transplantation there appears to be some benefit from oral glutamine in reducing mucositis and graft v. host disease, while intravenous glutamine may reduce infections but at the expense of an increased relapse rate. Good-quality studies are required in this area.