Applied Medicine (Department)
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Item Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)(2019) König, Magdalena; Berlin, Beata; Schwab, Karima; Frahm, Silke; Theuring, Franz; Wischik, Claude M; Harrington, Charles R; Riedel, Gernot; Klein, Jochen; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical SciencesItem A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy(2018-01-10) Schwab, Karima; Frahm, Silke; Horsley, David; Rickard, Janet E; Melis, Valeria; Goatman, Elizabeth A; Magbagbeolu, Mandy; Douglas, Morag; Leith, Michael G; Baddeley, Thomas C.; Storey, John M D; Riedel, Gernot; Wischik, Claude M; Harrington, Charles R; Theuring, Franz; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Sciences; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.ChemistryItem Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease(2018-02-26) Frahm, Silke; Melis, Valeria; Horsley, David; Rickard, Janet; Riedel, Gernot; Fadda, Paula; Scherma, Maria; Harrington, Charles; Wischik, Claude; Theuring, Franz; Schwab, Karima; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease : Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial(2017-11-28) Wilcock, Gordon K; Gauthier, Serge; Frisoni, Giovanni B; Jia, Jianping; Hardlund, Jiri H; Moebius, Hans J; Bentham, Peter; Kook, Karin A; Schelter, Bjoern Olaf; Wischik, Damon J; Davis, Charles S; Staff, Roger T; Vuksanovic, Vesna; Ahearn, Trevor; Bracoud, Luc; Shamsi, Kohkan; Marek, Ken; Seibyl, John; Riedel, Gernot; Storey, John M. D.; Harrington, Charles R; Wischik, Claude M; University of Aberdeen.Physics; University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB); University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Aberdeen Biomedical Imaging Centre; University of Aberdeen.ChemistryItem Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology(2016-07) Koss, David J.; Robinson, Lianne; Drever, Benjamin D.; Plucinska, Kaja; Stoppelkamp, Sandra; Veselcic, Peter; Riedel, Gernot; Platt, Bettina; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Applied MedicineItem Neuronal human BACE1 knock-in induces systemic diabetes in mice(2016-07) Plucinska, Kaja; Dekeryte, Ruta; Koss, David; Shearer, Kirsty; Mody, Nimesh; Whitfield, Phillip D.; Doherty, Mary K.; Mingarelli, Marco; Welch, Andy; Riedel, Gernot; Delibegovic, Mirela; Platt, Bettina; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Medical Sciences - Cardiovascular Group; University of Aberdeen.Applied Medicine; University of Aberdeen.Medical Education; University of Aberdeen.Aberdeen Biomedical Imaging CentreItem In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin(2016-07) Santoro, Matteo; Maetzler, Walter; Stathakos, Petros; Martin, Heather L.; Hobert, Markus A.; Rattray, Tim W.; Gasser, Thomas; Forrester, John V.; Berg, Daniela; Tracey, Kevin J.; Riedel, Gernot; Teismann, Peter; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied MedicineItem Evidence for a role of adaptive immune response in the disease pathogenesis of the MPTP mouse model of Parkinson’s disease(2016-03-01) Martin, Heather L.; Santoro, Matteo; Mustafa, Sarah; Riedel, Gernot; Forrester, John V.; Teismann, Peter; University of Aberdeen.Medical Sciences; University of Aberdeen.Medicine, Medical Sciences & Nutrition; University of Aberdeen.Applied MedicineItem Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models(2015-06) Melis, Valeria; Magbagbeolu, Mandy; Rickard, Janet E; Horsley, David; Davidson, Kathleen; Harrington, Kathleen A; Goatman, Keith; Goatman, Elizabeth A; Deiana, Serena; Close, Steve P; Zabke, Claudia; Stamer, Karsten; Dietze, Silke; Schwab, Karima; Storey, John M D; Harrington, Charles R; Wischik, Claude M; Theuring, Franz; Riedel, Gernot; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Epidemiology Group; University of Aberdeen.Chemistry; University of Aberdeen.Medical SciencesItem Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1(2011-11-11) Platt, Bettina; Drever, Benjamin; Koss, David; Stoppelkamp, Sandra; Jyoti, Amar; Plano, Andrea; Utan, Aneli; Merrick, Georgina; Ryan, Duncan; Melis, Valeria; Wan, Hong; Mingarelli, Marco; Porcu, Emanuele; Scrocchi, Louise; Welch, Andy; Riedel, Gernot; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Aberdeen Biomedical Imaging Centre