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Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System

dc.contributor.authorPliotas, Christos
dc.contributor.authorGrayer, Samuel C
dc.contributor.authorEkkerman, Silvia
dc.contributor.authorChan, Anthony K. N.
dc.contributor.authorHealy, Jess
dc.contributor.authorMarius, Phedra
dc.contributor.authorBartlett, Wendy
dc.contributor.authorKhan, Amjad
dc.contributor.authorCortopassi, Wilian A.
dc.contributor.authorChandler, Shane A.
dc.contributor.authorRasmussen, Tim
dc.contributor.authorBenesch, Justin L. P.
dc.contributor.authorPaton, Robert S.
dc.contributor.authorClaridge, Timothy D. W.
dc.contributor.authorMiller, Samantha
dc.contributor.authorBooth, Ian R
dc.contributor.authorNaismith, James H.
dc.contributor.authorConway, Stuart J
dc.date.accessioned2018-06-28T23:03:31Z
dc.date.available2018-06-28T23:03:31Z
dc.date.issued2017-08
dc.identifier.citationPliotas , C , Grayer , S C , Ekkerman , S , Chan , A K N , Healy , J , Marius , P , Bartlett , W , Khan , A , Cortopassi , W A , Chandler , S A , Rasmussen , T , Benesch , J L P , Paton , R S , Claridge , T D W , Miller , S , Booth , I R , Naismith , J H & Conway , S J 2017 , ' Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System ' , Biochemistry , vol. 56 , no. 32 , pp. 4219-4234 . https://doi.org/10.1021/acs.biochem.7b00300en
dc.identifier.issn0006-2960
dc.identifier.otherPURE: 102014204
dc.identifier.otherPURE UUID: 59386047-5356-4fe4-a919-b2a2956f3d7e
dc.identifier.otherPubMed: 28656748
dc.identifier.otherScopus: 85027436303
dc.identifier.otherORCID: /0000-0002-8223-9693/work/76974595
dc.identifier.urihttp://hdl.handle.net/2164/10676
dc.descriptionThe project is supported by the Wellcome Trust (WT092552MA, WT100209MA) to IRB, JHN, SM, and SJC, a Biotechnology and Biological Sciences Research Council grant (BB/H017917/1), and a European Union Marie Curie ITN Award (NICHE; 289384) that supported SE. CP would also like to acknowledge additional support by a Tenovus Scotland grant award (T15/41). WAC is supported by a Science Without Borders scholarship. The authors would like to acknowledge that the work presented here made use of the Emerald High Performance Computing facility made available by the Centre for Innovation, formed by the universities of Oxford, Southampton, Bristol, and University College London in partnership with the STFC Rutherford Appleton Laboratory. RSP acknowledges the use of the EPSRC UK National Service for Computational Chemistry Software (NSCCS) at Imperial College London in carrying out this work (CHEM773). RSP is grateful to NVIDIA for the generous donation of Tesla GPUs as part of the academic partnership scheme. SJC and AC thank the European Commission for the award of a Marie Curie Fellowship to AC (660156, FLUOROKEF). SJC and SCG thank the EPSRC for studentship support forSCG. SJC thanks St. Hugh’s College, Oxford, for research support.en
dc.format.extent16
dc.language.isoeng
dc.relation.ispartofBiochemistryen
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Biochemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.biochem.7b00300en
dc.subjectBiophysical studiesen
dc.subjectcrystallographyen
dc.subjectprotein dimersen
dc.subjectmembrane proteinen
dc.subjectnucleotideen
dc.subjectQD Chemistryen
dc.subjectWellcome Trusten
dc.subjectWT092552MAen
dc.subjectWT100209MAen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/H017917/1en
dc.subjectEngineering and Physical Sciences Research Council (EPSRC)en
dc.subject.lccQDen
dc.titleAdenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux Systemen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Clinical Medicineen
dc.description.statusPeer revieweden
dc.description.versionPostprinten
dc.identifier.doihttps://doi.org/10.1021/acs.biochem.7b00300
dc.date.embargoedUntil2018-06-28


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