dc.contributor.author | Testa, Andrea | |
dc.contributor.author | Lucas, Xavier | |
dc.contributor.author | Castro, Guilherme V. | |
dc.contributor.author | Chan, Kwok-Ho | |
dc.contributor.author | Wright, Jane E. | |
dc.contributor.author | Runcie, Andrew C. | |
dc.contributor.author | Gadd, Morgan S. | |
dc.contributor.author | Harrison, William T. A. | |
dc.contributor.author | Ko, Eun-Jung | |
dc.contributor.author | Fletcher, Daniel | |
dc.contributor.author | Ciulli, Alessio | |
dc.date.accessioned | 2018-07-16T11:53:09Z | |
dc.date.available | 2018-07-16T11:53:09Z | |
dc.date.issued | 2018-07-25 | |
dc.identifier.citation | Testa , A , Lucas , X , Castro , G V , Chan , K-H , Wright , J E , Runcie , A C , Gadd , M S , Harrison , W T A , Ko , E-J , Fletcher , D & Ciulli , A 2018 , ' 3-Fluoro-4-hydroxyprolines : Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation ' , Journal of the American Chemical Society , vol. 140 , no. 29 , pp. 9299-9313 . https://doi.org/10.1021/jacs.8b05807 , https://doi.org/10.1021/jacs.9b03833 | en |
dc.identifier.issn | 0002-7863 | |
dc.identifier.other | PURE: 125973411 | |
dc.identifier.other | PURE UUID: 77896a5b-69a4-40cf-8fdb-c2d4a55669db | |
dc.identifier.other | Scopus: 85049368469 | |
dc.identifier.uri | http://hdl.handle.net/2164/10750 | |
dc.description | Correction published online 24th April 2019, in issue 8th May 2019. J. Am. Chem. Soc.2019141187644 Funding Sources This project has received funding from the European Research Council (ERC) under the European Union’s Seventh Framework Programme (FP7/2007-2013) as a Starting Grant to A.C. (grant agreement No. ERC-2012-StG-311460 DrugE3CRLs). X.L. and K.-H. C. were supported by Marie Skłodowska-Curie Actions Individual Fellowships from the European Commission (H2020-MSCA-IF-2015-806323 and H2020-MSCA-IF-2014-655516, respectively). G. C. was supported by a Ph.D. Studentship from the Ministério da Educação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, No. 7148-14-3). Biophysics and drug discovery activities are supported by Wellcome Trust strategic awards to Dundee (100476/Z/12/Z and 094090/Z/10/Z, respectively). We thank Professor B. Linclau for helpful discussions, P. Fyfe for support with in-house X-ray facilities, and to the Diamond Light Source for beamtime (BAG proposal MX10071) and beamline support at beamline I04-1. | en |
dc.format.extent | 15 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of the American Chemical Society | en |
dc.rights | ACS AuthorChoice - This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. https://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html https://creativecommons.org/licenses/by/4.0/ | en |
dc.rights | This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. https://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | QD Chemistry | en |
dc.subject | European Research Council | en |
dc.subject | FP7/2007-2013 | en |
dc.subject | ERC-2012-StG-311460 DrugE3CRLs | en |
dc.subject | European Commission | en |
dc.subject | H2020-MSCA-IF-2015-806323 | en |
dc.subject | H2020-MSCA-IF-2014-655516 | en |
dc.subject | Wellcome Trust | en |
dc.subject | 100476/Z/12/Z | en |
dc.subject | 094090/Z/10/Z | en |
dc.subject | Supplementary Data | en |
dc.subject.lcc | QD | en |
dc.title | 3-Fluoro-4-hydroxyprolines : Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation | en |
dc.type | Journal article | en |
dc.contributor.institution | University of Aberdeen.Chemistry | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Publisher PDF | en |
dc.description.version | Other | en |
dc.identifier.doi | https://doi.org/10.1021/jacs.8b05807 | |
dc.identifier.vol | 140 | en |
dc.identifier.iss | 29 | en |