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3-Fluoro-4-hydroxyprolines : Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

dc.contributor.authorTesta, Andrea
dc.contributor.authorLucas, Xavier
dc.contributor.authorCastro, Guilherme V.
dc.contributor.authorChan, Kwok-Ho
dc.contributor.authorWright, Jane E.
dc.contributor.authorRuncie, Andrew C.
dc.contributor.authorGadd, Morgan S.
dc.contributor.authorHarrison, William T. A.
dc.contributor.authorKo, Eun-Jung
dc.contributor.authorFletcher, Daniel
dc.contributor.authorCiulli, Alessio
dc.date.accessioned2018-07-16T11:53:09Z
dc.date.available2018-07-16T11:53:09Z
dc.date.issued2018-07-25
dc.identifier.citationTesta , A , Lucas , X , Castro , G V , Chan , K-H , Wright , J E , Runcie , A C , Gadd , M S , Harrison , W T A , Ko , E-J , Fletcher , D & Ciulli , A 2018 , ' 3-Fluoro-4-hydroxyprolines : Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation ' , Journal of the American Chemical Society , vol. 140 , no. 29 , pp. 9299-9313 . https://doi.org/10.1021/jacs.8b05807 , https://doi.org/10.1021/jacs.9b03833en
dc.identifier.issn0002-7863
dc.identifier.otherPURE: 125973411
dc.identifier.otherPURE UUID: 77896a5b-69a4-40cf-8fdb-c2d4a55669db
dc.identifier.otherScopus: 85049368469
dc.identifier.urihttp://hdl.handle.net/2164/10750
dc.descriptionCorrection published online 24th April 2019, in issue 8th May 2019. J. Am. Chem. Soc.2019141187644 Funding Sources This project has received funding from the European Research Council (ERC) under the European Union’s Seventh Framework Programme (FP7/2007-2013) as a Starting Grant to A.C. (grant agreement No. ERC-2012-StG-311460 DrugE3CRLs). X.L. and K.-H. C. were supported by Marie Skłodowska-Curie Actions Individual Fellowships from the European Commission (H2020-MSCA-IF-2015-806323 and H2020-MSCA-IF-2014-655516, respectively). G. C. was supported by a Ph.D. Studentship from the Ministério da Educação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, No. 7148-14-3). Biophysics and drug discovery activities are supported by Wellcome Trust strategic awards to Dundee (100476/Z/12/Z and 094090/Z/10/Z, respectively). We thank Professor B. Linclau for helpful discussions, P. Fyfe for support with in-house X-ray facilities, and to the Diamond Light Source for beamtime (BAG proposal MX10071) and beamline support at beamline I04-1.en
dc.format.extent15
dc.language.isoeng
dc.relation.ispartofJournal of the American Chemical Societyen
dc.rightsACS AuthorChoice - This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. https://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html https://creativecommons.org/licenses/by/4.0/en
dc.rightsThis is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. https://creativecommons.org/licenses/by/4.0/en
dc.subjectQD Chemistryen
dc.subjectEuropean Research Councilen
dc.subjectFP7/2007-2013en
dc.subjectERC-2012-StG-311460 DrugE3CRLsen
dc.subjectEuropean Commissionen
dc.subjectH2020-MSCA-IF-2015-806323en
dc.subjectH2020-MSCA-IF-2014-655516en
dc.subjectWellcome Trusten
dc.subject100476/Z/12/Zen
dc.subject094090/Z/10/Zen
dc.subjectSupplementary Dataen
dc.subject.lccQDen
dc.title3-Fluoro-4-hydroxyprolines : Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradationen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.description.versionOtheren
dc.identifier.doihttps://doi.org/10.1021/jacs.8b05807
dc.identifier.vol140en
dc.identifier.iss29en


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