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Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

dc.contributor.authorAvgustinova, Alexandra
dc.contributor.authorIravani, Marjan
dc.contributor.authorRobertson, David
dc.contributor.authorFearns, Antony
dc.contributor.authorGao, Qiong
dc.contributor.authorKlingbeil, Pamela
dc.contributor.authorHanby, Andrew M
dc.contributor.authorSpeirs, Valerie
dc.contributor.authorSahai, Erik
dc.contributor.authorCalvo, Fernando
dc.contributor.authorIsacke, Clare M
dc.date.accessioned2018-07-20T15:48:04Z
dc.date.available2018-07-20T15:48:04Z
dc.date.issued2016-01-18
dc.identifier.citationAvgustinova , A , Iravani , M , Robertson , D , Fearns , A , Gao , Q , Klingbeil , P , Hanby , A M , Speirs , V , Sahai , E , Calvo , F & Isacke , C M 2016 , ' Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness ' , Nature Communications , vol. 7 , 10305 . https://doi.org/10.1038/ncomms10305en
dc.identifier.issn2041-1723
dc.identifier.otherPURE: 129546814
dc.identifier.otherPURE UUID: a0bffde8-73e3-4ceb-9564-54e053d6a112
dc.identifier.otherPubMed: 26777421
dc.identifier.otherPubMedCentral: PMC4735631
dc.identifier.otherScopus: 84954525154
dc.identifier.otherORCID: /0000-0002-0602-4666/work/72631293
dc.identifier.urihttp://hdl.handle.net/2164/10774
dc.descriptionThis work was funded by Breakthrough Breast Cancer (recently merged with Breast Cancer Campaign forming Breast Cancer Now; C.M.I.), Cancer Research UK (A.A., E.S. and CMI) and Breast Cancer Campaign (V.S. and A.H.). F.C. is currently funded by The Institute of Cancer Research and Worldwide Cancer Research. We acknowledge NHS funding to the NIHR Biomedical Research Centre at The Royal Marsden and the ICR. We thank the Breakthrough Histopathology Facility, Cambridge Genomic Services for the gene expression analysis, Balazs Gyorffy for providing the clinical breast cancer outcome data, Antoinette van Weverwijk for help with the in vivo assays, Fredrik Wallberg for help with the FACSorting, Andrea Morandi for help with the TMA analysis, Patricia Salinas for the Wnt7a cDNA construct and helpful discussions and Lorenzo Melchor for the pDEST/pHIV-H2BmRFP-rfa_verB Gateway cloning vector.en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAnimalsen
dc.subjectBreast Neoplasmsen
dc.subjectFemaleen
dc.subjectFibroblastsen
dc.subjectGene Expression Regulation, Neoplasticen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectNIH 3T3 Cellsen
dc.subjectWnt Proteinsen
dc.subjectJournal Articleen
dc.subjectResearch Support, Non-U.S. Gov'ten
dc.subjectR Medicineen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleTumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressivenessen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1038/ncomms10305
dc.identifier.vol7en


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