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Alternative (backdoor) androgen production and masculinization in the human fetus

dc.contributor.authorO'Shaughnessy, Peter J.
dc.contributor.authorAntignac, Jean-Philippe
dc.contributor.authorLe Bizec, Bruno
dc.contributor.authorMorvan, Marie-Line
dc.contributor.authorSvechnikov, Konstantin
dc.contributor.authorSöder, Olle
dc.contributor.authorSavchuk, Iuliia
dc.contributor.authorMonteiro, Ana
dc.contributor.authorSoffientini, Ugo
dc.contributor.authorJohnston, Zoe C.
dc.contributor.authorBellingham, Michelle
dc.contributor.authorHough, Denise
dc.contributor.authorWalker, Natasha
dc.contributor.authorFilis, Panagiotis
dc.contributor.authorFowler , Paul A.
dc.date.accessioned2019-02-21T15:50:06Z
dc.date.available2019-02-21T15:50:06Z
dc.date.issued2019-02-14
dc.identifier.citationO'Shaughnessy , P J , Antignac , J-P , Le Bizec , B , Morvan , M-L , Svechnikov , K , Söder , O , Savchuk , I , Monteiro , A , Soffientini , U , Johnston , Z C , Bellingham , M , Hough , D , Walker , N , Filis , P & Fowler , P A 2019 , ' Alternative (backdoor) androgen production and masculinization in the human fetus ' , PLoS Biology , vol. 17 , no. 2 , e3000002 . https://doi.org/10.1371/journal.pbio.3000002 , https://doi.org/10.1371/journal.pbio.3000002.s004 , https://doi.org/10.1371/journal.pbio.3000002.s001 , https://doi.org/10.1371/journal.pbio.3000002.s002 , https://doi.org/10.1371/journal.pbio.3000002.s003 , https://doi.org/10.1371/journal.pbio.3000002.s005 , https://doi.org/10.1371/journal.pbio.3000002.s006 , https://doi.org/10.1371/journal.pbio.3000002.s007 , https://doi.org/10.1371/journal.pbio.3000002.s008 , https://doi.org/10.1371/journal.pbio.3000002.s009en
dc.identifier.issn1544-9173
dc.identifier.otherPURE: 141670906
dc.identifier.otherPURE UUID: 62d44ae4-658a-4b9d-9a25-860fc63d42cd
dc.identifier.otherScopus: 85061570315
dc.identifier.otherORCID: /0000-0002-4831-9075/work/56076470
dc.identifier.otherMendeley: 9b37ef82-c5eb-3fa0-954a-9f3038f578b8
dc.identifier.otherWOS: 000460317100008
dc.identifier.urihttp://hdl.handle.net/2164/11944
dc.descriptionFunding: The study was supported by the following grants: Chief Scientist Office (Scottish Executive, CZG/4/742) (PAF and PJOS) (http://www.cso.scot.nhs.uk/funding-2/); NHS Grampian Endowments 08/02 (PAF and PJOS) and 15/1/010 (PAF, PF, US, and PJOS) (https://www.nhsgcharities.com/); the Glasgow Children’s Hospital Research Charity Research Fund, YRSS/PHD/2016/05 (NW, MB, PJOS, and PAF) (http://www.glasgowchildrenshospitalcharity.org/research/glasgow-childrens-hospital-charity-research-fund); the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement number 212885 (PAF) (https://ec.europa.eu/research/fp7/index_en.cfm); Medical Research Council Grants MR/L010011/1 (PAF and PJOS) and MR/K501335/1 (MB, PAF, and PJOS) (https://mrc.ukri.org/); and the Kronprinsessan Lovisas Foundation, “Stiftelsen Gunvor och Josef Anérs,” the “Stiftelsen Jane och Dan Olssons,” and the “Stiftelsen Tornspiran” (KS and OS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.format.extent23
dc.language.isoeng
dc.relation.ispartofPLoS Biologyen
dc.rights© 2019 O’Shaughnessy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectandrogenen
dc.subjectalternative pathwayen
dc.subjectandrosteroneen
dc.subjectmasculinisationen
dc.subjecthumanen
dc.subjectfetalen
dc.subjecttestisen
dc.subjectplacentaen
dc.subjectadrenalen
dc.subjectliveren
dc.subjectbackdoor pathwayen
dc.subjectFETAL PLASMAen
dc.subjectWALLABY POUCH YOUNGen
dc.subject17,20-LYASE ACTIVITYen
dc.subjectENZYME EXPRESSIONen
dc.subjectMASS-SPECTROMETRYen
dc.subjectPLASMA TESTOSTERONEen
dc.subjectP450 OXIDOREDUCTASEen
dc.subjectBIOSYNTHESISen
dc.subjectGENE-EXPRESSIONen
dc.subjectMATERNAL SMOKINGen
dc.subjectR Medicineen
dc.subjectAgricultural and Biological Sciences(all)en
dc.subjectBiochemistry, Genetics and Molecular Biology(all)en
dc.subjectImmunology and Microbiology(all)en
dc.subjectNeuroscience(all)en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/L010011/1en
dc.subjectMR/K501335/1en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleAlternative (backdoor) androgen production and masculinization in the human fetusen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1371/journal.pbio.3000002
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85061570315&partnerID=8YFLogxKen
dc.identifier.urlhttp://www.mendeley.com/research/alternative-backdoor-androgen-production-masculinization-human-fetusen
dc.identifier.vol17en
dc.identifier.iss2en


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