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The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors

dc.contributor.authorThompson, Aiysha
dc.contributor.authorDavies, Luke C.
dc.contributor.authorLaio, Chia-Te
dc.contributor.authorda Fonseca, Diogo M.
dc.contributor.authorGriffiths, James S.
dc.contributor.authorAndrews, Robert
dc.contributor.authorJones, Adam V.
dc.contributor.authorClement, Mathew
dc.contributor.authorBrown, Gordon D.
dc.contributor.authorHumphreys, Ian R.
dc.contributor.authorTaylor, Philip R.
dc.contributor.authorOrr, Selinda J.
dc.date.accessioned2019-07-02T10:40:11Z
dc.date.available2019-07-02T10:40:11Z
dc.date.issued2019-06-26
dc.identifier.citationThompson , A , Davies , L C , Laio , C-T , da Fonseca , D M , Griffiths , J S , Andrews , R , Jones , A V , Clement , M , Brown , G D , Humphreys , I R , Taylor , P R & Orr , S J 2019 , ' The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors ' , PLoS Pathogens , vol. 15 , no. 6 , e1007850 . https://doi.org/10.1371/journal.ppat.1007850en
dc.identifier.issn1553-7366
dc.identifier.otherPURE: 144312005
dc.identifier.otherPURE UUID: 6e52d2e0-9eac-469c-98a6-9e41a9cf7f46
dc.identifier.otherMendeley: 1c16722a-b5ed-3c4e-98d8-fb48d6ceca8a
dc.identifier.otherScopus: 85068915474
dc.identifier.otherPubMed: 31242262
dc.identifier.otherWOS: 000479154700041
dc.identifier.urihttp://hdl.handle.net/2164/12477
dc.identifier.urihttp://www.mendeley.com/research/protective-effect-inflammatory-monocytes-during-systemic-c-albicans-infection-dependent-collaboratioen
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85068915474&partnerID=8YFLogxKen
dc.descriptionAcknowledgments The authors wish to acknowledge the NIH-sponsored Mutant Mouse Regional Resource Center (MMRRC) National System as the source of genetically-altered mice (C57BL/6-Clec4etm1.1Cfg/Mmucd 031936-UCD) for use in this study. The mice were produced and deposited to the MMRRC by the Consortium for Functional Glycomics supported by the National Institute of General Medical Sciences (GM62116). We would like to thank Catherine Neiseryan and Ann Kift-Morgan for cell sorting. We would like to thank Wales Gene Park for providing computer resources that assisted this research. Funding: SJO was funded by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 099953/Z/12/Z) and by a Wellcome Trust ISSF Cross-Disciplinary Award. LCD is supported by a Henry Wellcome Trust Postdoctoral Fellowship (103973/Z/14/Z). CL is supported by a Kidney Research UK/MedImmune Joint Fellowship Award (PDF_006_20151127). GDB is funded by a Wellcome Trust Investigator Award (102705) and the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). IRH is supported by a Wellcome Trust Senior Research Fellowship (207503/Z/17/Z). PRT is supported by a Wellcome Trust Investigator Award (107964/Z/15/Z) and the UK Dementia Research Institute. Funding URLs: https://wellcome.ac.uk/ https://royalsociety.org/ https://www.kidneyresearchuk.org/ https://mrc.ukri.org/ https://ukdri.ac.uk/ The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Data Availability: All relevant data apart from RNAseq files are within the manuscript and its Supporting Information files. RNAseq data files are available from ArrayExpress (https://www.ebi.ac.uk/arrayexpress/), (accession number E-MTAB-8030).en
dc.format.extent29
dc.language.isoeng
dc.relation.ispartofPLoS Pathogensen
dc.rights© 2019 Thompson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. https://creativecommons.org/licenses/by/4.0/en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectHOST-DEFENSEen
dc.subjectDENDRITIC CELLSen
dc.subjectHUMAN DECTIN-1en
dc.subjectCANDIDAen
dc.subjectINDUCTIONen
dc.subjectPATHWAYen
dc.subjectPOLYMORPHISMen
dc.subjectRECOGNITIONen
dc.subjectRESPONSESen
dc.subjectMINCLEen
dc.subjectR Medicine (General)en
dc.subjectGeneticsen
dc.subjectMolecular Biologyen
dc.subjectVirologyen
dc.subjectParasitologyen
dc.subjectMicrobiologyen
dc.subjectImmunologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/1en
dc.subjectOtheren
dc.subjectPDF_006_20151127en
dc.subjectWellcome Trusten
dc.subject099953/Z/12/Zen
dc.subject103973/Z/14/Zen
dc.subject102705en
dc.subject207503/Z/17/Zen
dc.subject107964/Z/15/Zen
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleThe protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptorsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1371/journal.ppat.1007850
dc.identifier.urlhttp://www.mendeley.com/research/protective-effect-inflammatory-monocytes-during-systemic-c-albicans-infection-dependent-collaboratioen
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85068915474&partnerID=8YFLogxKen
dc.identifier.vol15en
dc.identifier.iss6en


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