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The molecular aetiology of tRNA synthetase depletion : induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels

dc.contributor.authorMcFarland, Matthew R.
dc.contributor.authorKeller, Corina D.
dc.contributor.authorChilders, Brandon M.
dc.contributor.authorAdeniyi, Stephen A.
dc.contributor.authorCorrigall, Holly
dc.contributor.authorRaguin, Adélaïde
dc.contributor.authorRomano, M. Carmen
dc.contributor.authorStansfield, Ian
dc.date.accessioned2019-08-29T09:00:07Z
dc.date.available2019-08-29T09:00:07Z
dc.date.issued2020-04-06
dc.identifier.citationMcFarland , M R , Keller , C D , Childers , B M , Adeniyi , S A , Corrigall , H , Raguin , A , Romano , M C & Stansfield , I 2020 , ' The molecular aetiology of tRNA synthetase depletion : induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels ' , Nucleic Acids Research , vol. 48 , no. 6 , pp. 3071-3088 . https://doi.org/10.1101/610790 , https://doi.org/10.1093/nar/gkaa055en
dc.identifier.issn0305-1048
dc.identifier.otherPURE: 155287598
dc.identifier.otherPURE UUID: b4c17428-b3c5-42be-adf7-2eed8ab8fcdc
dc.identifier.otherORCID: /0000-0002-7242-7906/work/59921156
dc.identifier.otherPubMed: 32016368
dc.identifier.otherWOS: 000525957500026
dc.identifier.otherScopus: 85082561691
dc.identifier.urihttp://hdl.handle.net/2164/12805
dc.descriptionBiotechnology and Biological Sciences Research Council (BBSRC) [BB/I020926/1 to I.S., BB/N017161/1 to I.S., M.C.R.]; BBSRC PhD studentship awards [M108703G, C103817D to I.S. and M.C.R.]. Funding for open access charge: Biotechnology and Biological Sciences Research Council.en
dc.format.extent18
dc.language.isoeng
dc.relation.ispartofNucleic Acids Researchen
dc.rightsThe copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjecttranslationen
dc.subjecttRNA synthetaseen
dc.subjectSaccharomyces cerevisiaeen
dc.subjectGCN4en
dc.subjectTotally Asymmetric Simple Exclusion Processen
dc.subjectFACTOR 2B COMPLEXen
dc.subjectTRANSLATIONAL REGULATIONen
dc.subjectESCHERICHIA-COLIen
dc.subjectYEASTen
dc.subjectMESSENGER-RNASen
dc.subjectIN-VIVOen
dc.subjectGROWTHen
dc.subjectGENOME-WIDE ANALYSISen
dc.subjectGENE-EXPRESSIONen
dc.subjectMUTATIONSen
dc.subjectR Medicine (General)en
dc.subjectGeneticsen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/I020926/1en
dc.subjectBB/N017161/1en
dc.subjectM108703Gen
dc.subjectC103817Den
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleThe molecular aetiology of tRNA synthetase depletion : induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levelsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.East Bioen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Physicsen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB)en
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPreprinten
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1101/610790
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85082561691&partnerID=8YFLogxKen
dc.identifier.vol48en
dc.identifier.iss6en


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