This is the peer reviewed version of the following article: Westbrook, J. A., Wood, S. L., Cairns, D. A., McMahon, K. , Gahlaut, R. , Thygesen, H. , Shires, M. , Roberts, S. , Marshall, H. , Oliva, M. R., Dunning, M. J., Hanby, A. M., Selby, P. J., Speirs, V. , Mavria, G. , Coleman, R. E. and Brown, J. E. (2019), Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer. J. Pathol., 247: 381-391., which has been published in final form at https://doi.org/10.1002/path.5197. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.