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dc.contributor.authorAl-Hilaly, Youssra K
dc.contributor.authorFoster, Bronwen E
dc.contributor.authorBiasetti, Luca
dc.contributor.authorLutter, Liisa
dc.contributor.authorPollack, Saskia J
dc.contributor.authorRickard, Janet E
dc.contributor.authorStorey, John M D
dc.contributor.authorHarrington, Charles R
dc.contributor.authorXue, Wei-Feng
dc.contributor.authorWischik, Claude M
dc.contributor.authorSerpell, Louise C
dc.date.accessioned2019-12-20T15:55:00Z
dc.date.available2019-12-20T15:55:00Z
dc.date.issued2020-03-01
dc.identifier.citationAl-Hilaly , Y K , Foster , B E , Biasetti , L , Lutter , L , Pollack , S J , Rickard , J E , Storey , J M D , Harrington , C R , Xue , W-F , Wischik , C M & Serpell , L C 2020 , ' Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain ' , FEBS LETTERS , vol. 594 , no. 5 , pp. 944-950 . https://doi.org/10.1002/1873-3468.13675en
dc.identifier.issn0014-5793
dc.identifier.otherPURE: 153094830
dc.identifier.otherPURE UUID: 63643b6d-e8d0-4e07-a87c-36d1b19f9107
dc.identifier.otherPubMed: 31721178
dc.identifier.otherScopus: 85075938961
dc.identifier.otherORCID: /0000-0002-5261-5467/work/73579166
dc.identifier.urihttps://hdl.handle.net/2164/13414
dc.descriptionAcknowledgements We acknowledge Biochemical society for funding forBF. YA acknowledges Mustansiriyah University,Baghdad, Iraq (www.uomustansiriyah.edu.iq), for sup-port. We thank Pascale Schellenberger for valuablehelp and training with TEM. The human tissue wasprovided by the London Neurodegenerative DiseasesBrain Bank. Respectfully, we thank the anonymoustissue donors and their next of kin. We thank fundingfrom the BBSRC (BB/S003312/1, WFX and LCS) andthe EPSRC (EP/R513246/1, LL).Author contributionsYA managed the project, conceived the idea and pre-pared the samples. YA and BF collected and analysedthe TEM data; LB provided training and sectioned thebrain sample; YA, LL and WFX collected the AFMdata; and LL and WFX analysed the AFM data. JERprepared the purified dGAE protein. YA, BF and LSwrote the first draft and all authors reviewed themanuscript and approved the final version. CH, CWand LS managed the overall project. Ethics AD brain tissue was provided by the London Neu-rodegenerative Diseases Brain Bank, Institute of Psy-chiatry, King’s College, London, under Local EthicsCommittee guidelines, and informed consent for braindonation was obtained from the next of kin by theLondon Neurodegenerative Diseases Brain Bank.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofFEBS LETTERSen
dc.rights© 2019 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/en
dc.subjectAlzheimer’s diseaseen
dc.subjectneurofibrillary tanglesen
dc.subjectpaired helical filamentsen
dc.subjecttauen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectGeneticsen
dc.subjectMolecular Biologyen
dc.subjectBiophysicsen
dc.subjectStructural Biologyen
dc.subjectBiochemistryen
dc.subjectCell Biologyen
dc.subjectEngineering and Physical Sciences Research Council (EPSRC)en
dc.subjectEP/R513246/1, LLen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/S003312/en
dc.subject.lccRC0321en
dc.titleTau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brainen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Chemistry (Research Theme)en
dc.contributor.institutionUniversity of Aberdeen.Clinical Medicineen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1002/1873-3468.13675
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85075938961&partnerID=8YFLogxKen


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