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dc.contributor.authorCook, Jonathan A.
dc.contributor.authorJulious, Steven A.
dc.contributor.authorSones, William
dc.contributor.authorHampson, Lisa V.
dc.contributor.authorHewitt, Catherine
dc.contributor.authorBerlin, Jesse A.
dc.contributor.authorAshby, Deborah
dc.contributor.authorEmsley, Richard
dc.contributor.authorFergusson, Dean A.
dc.contributor.authorWalters, Stephen J.
dc.contributor.authorWilson, Edward C.F.
dc.contributor.authorMaclennan, Graeme
dc.contributor.authorStallard, Nigel
dc.contributor.authorRothwell, Joanne C.
dc.contributor.authorBland, Martin
dc.contributor.authorBrown, Louise
dc.contributor.authorRamsay, Craig R.
dc.contributor.authorCook, Andrew
dc.contributor.authorArmstrong, David
dc.contributor.authorAltman, Douglas
dc.contributor.authorVale, Luke D.
dc.date.accessioned2020-01-07T16:15:01Z
dc.date.available2020-01-07T16:15:01Z
dc.date.issued2019-10-30
dc.identifier.citationCook , J A , Julious , S A , Sones , W , Hampson , L V , Hewitt , C , Berlin , J A , Ashby , D , Emsley , R , Fergusson , D A , Walters , S J , Wilson , E C F , Maclennan , G , Stallard , N , Rothwell , J C , Bland , M , Brown , L , Ramsay , C R , Cook , A , Armstrong , D , Altman , D & Vale , L D 2019 , ' Practical help for specifying the target difference in sample size calculations for RCTs : The DELTA 2 five-stage study, including a workshop ' , Health Technology Assessment , vol. 23 , no. 60 . https://doi.org/10.3310/hta23600en
dc.identifier.issn1366-5278
dc.identifier.otherPURE: 153094439
dc.identifier.otherPURE UUID: 6cdfe5a2-b593-4140-90aa-cd0d16702536
dc.identifier.otherScopus: 85074259328
dc.identifier.otherPubMed: 31661431
dc.identifier.otherORCID: /0000-0003-4043-7349/work/84131500
dc.identifier.urihttps://hdl.handle.net/2164/13466
dc.descriptionAcknowledgements This project was funded by the MRC NIHR Methodology Research Programme in the UK in response to a commissioned call to lead a workshop on this topic in order to produce guidance. The members of the original DELTA2 group were Associate Professor Jonathan Cook, Professor Douglas Altman, Dr Jesse Berlin, Professor Martin Bland, Professor Richard Emsley, Dr Dean Fergusson, Dr Lisa Hampson, Professor Catherine Hewitt, Professor Craig Ramsay, Miss Joanne Rothwell, Dr Robert Smith, Dr William Sones, Professor Luke Vale, Professor Stephen Walters and Professor Steve Julious. As part of the process of developing this document, a 2-day workshop was held in Oxford in September 2016. The workshop participants were Professor Douglas Altman, Professor David Armstrong, Professor Deborah Ashby, Professor Martin Bland, Dr Andrew Cook, Professor Jonathan Cook, Dr David Crosby, Professor Richard Emsley, Dr Dean Fergusson, Professor Andrew Grieve, Dr Lisa Hampson, Professor Catherine Hewitt, Professor Steve Julious, Professor Graeme MacLennan, Professor Tim Maughan, Professor Jon Nicholl, Dr José Pinheiro, Professor Craig Ramsay, Miss Joanne Rothwell, Dr William Sones, Professor Nigel Stallard, Professor Luke Vale, Professor Stephen Walters and Dr Ed Wilson. The authors would like to acknowledge and thank the participants in the Delphi exercise and the one-off engagement sessions with various groups, including the SCT, PSI and JSM conference session attendees, along with the other workshop participants who kindly provided helpful input and comments on the scope and content of this document. We would also like to thank, in particular, Dr Robert Smith in his role as a member of the public who provided a helpful public perspective during the workshop and in the development and revision of this document. Finally, the authors would like to thank Stefano Vezzoli for in-depth comments that helped to refine this document, helpful feedback from the MRC Methodological Research Programme Advisory Group, and representatives of the Medicines and Healthcare products Regulatory Agency and Health and Social Care, Northern Ireland. Dedication This work is dedicated to Douglas Altman, an inspirational researcher, friend and colleague. Contributions of authors Jonathan A Cook (Professor) drafted the initial version of the manuscript, and read and approved the final version. Steven A Julious (Professor) drafted the initial version of the manuscript and read and approved the final version. William Sones (Statistician) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Lisa V Hampson (Associate Director) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Catherine Hewitt (Professor) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Jesse A Berlin (Vice President and Global Head of Epidemiology) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Deborah Ashby (Co-Director) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Richard Emsley (Professor) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Dean A Fergusson (Senior Scientist and Director) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Stephen J Walters (Professor) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Edward CF Wilson (Senior Research Associate in Health Economics) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Graeme MacLennan (Director and Professor) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Nigel Stallard (Professor) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Joanne C Rothwell (PhD student) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Martin Bland (Professor) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Louise Brown (Senior Statistician) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Craig R Ramsay (Director and Professor) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Andrew Cook (Consultant in Public Health Medicine and Fellow in Health Technology Assessment) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. David Armstrong (Professor) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Douglas Altman (Professor) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version. Luke D Vale (Professor) contributed to the development of the document, commented on the draft manuscript, and read and approved the final version.en
dc.format.extent118
dc.language.isoeng
dc.relation.ispartofHealth Technology Assessmenten
dc.rights© Queen’s Printer and Controller of HMSO 2019. This work was produced by Cook et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.en
dc.subjectR Medicineen
dc.subjectHealth Policyen
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectMRC NIHR Methodology Research Programmeen
dc.subject.lccRen
dc.titlePractical help for specifying the target difference in sample size calculations for RCTs : The DELTA2 five-stage study, including a workshopen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.The Centre for Healthcare Randomised Trials (CHaRT)en
dc.contributor.institutionUniversity of Aberdeen.Health Services Research Uniten
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Public Health, Health Services and Primary Careen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.3310/hta23600
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85074259328&partnerID=8YFLogxKen


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