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A Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metabolite

dc.contributor.authorMaglangit, Fleurdeliz
dc.contributor.authorFang, Qing
dc.contributor.authorKyeremeh, Kwaku
dc.contributor.authorSternberg, Jeremy M
dc.contributor.authorEbel, Rainer
dc.contributor.authorDeng, Hai
dc.date.accessioned2020-01-15T09:45:01Z
dc.date.available2020-01-15T09:45:01Z
dc.date.issued2020-01-08
dc.identifier.citationMaglangit , F , Fang , Q , Kyeremeh , K , Sternberg , J M , Ebel , R & Deng , H 2020 , ' A Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metabolite ' , Molecules , vol. 25 , no. 2 , 256 . https://doi.org/10.3390/molecules25020256en
dc.identifier.issn1420-3049
dc.identifier.otherPURE: 154586916
dc.identifier.otherPURE UUID: dec30545-b488-4f17-ae65-c9ef27793516
dc.identifier.otherPubMed: 31936318
dc.identifier.otherScopus: 85077857962
dc.identifier.otherWOS: 000515381800018
dc.identifier.otherORCID: /0000-0002-8479-5482/work/75817053
dc.identifier.otherunpaywall: 10.3390/molecules25020256
dc.identifier.urihttps://hdl.handle.net/2164/13522
dc.descriptionFM thanks the University of the Philippines Faculty, Reps, and Staff Development Program (FRASDP) for the PhD grant fellowship. HD and KK are grateful for the financial support of the Leverhulme Trust‐Royal Society Africa award (AA090088) and the jointly funded UK Medical Research Council–UK Department for International Development (MRC/DFID) Concordat Agreement African Research Leaders Award (MR/S00520X/1). RE is grateful to British Council/Newton Fund for financial support through the Institutional Links scheme (Project No. 261781172). QF is grateful to the University of Aberdeen Elphinstone Scholarship and the Scottish Funding Council/ScotCHEM for financial support through PEER/PERCE Fundingen
dc.format.extent16
dc.language.isoeng
dc.relation.ispartofMoleculesen
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectsilent genesen
dc.subjectcryptic genesen
dc.subjectco-cultureen
dc.subjectStreptomyces sp. MA37en
dc.subjectPseudomonas sp.en
dc.subjectindolocarbazoleen
dc.subjectalkaloiden
dc.subjectAFRICAN TRYPANOSOMESen
dc.subjectPHASE-IIen
dc.subjectPseudomonas spen
dc.subjectINDOLOCARBAZOLEen
dc.subjectPROTEIN-KINASESen
dc.subjectGENE-CLUSTERen
dc.subjectCHEMICAL DIVERSITYen
dc.subjectCHROMOPYRROLIC ACIDen
dc.subjectStreptomyces spen
dc.subjectANTITUMOR SUBSTANCEen
dc.subjectMA37en
dc.subjectREBECCAMYCIN ANALOGen
dc.subjectHETEROLOGOUS EXPRESSIONen
dc.subjectIndolocarbazoleen
dc.subjectAlkaloiden
dc.subjectSilent genesen
dc.subjectCryptic genesen
dc.subjectCo-cultureen
dc.subjectQD Chemistryen
dc.subjectDrug Discoveryen
dc.subjectAnalytical Chemistryen
dc.subjectChemistry (miscellaneous)en
dc.subjectMolecular Medicineen
dc.subjectPhysical and Theoretical Chemistryen
dc.subjectPharmaceutical Scienceen
dc.subjectOrganic Chemistryen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/S00520X/1en
dc.subjectSupplementary Dataen
dc.subject.lccQDen
dc.titleA Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metaboliteen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Natural & Computing Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.3390/molecules25020256
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85077857962&partnerID=8YFLogxKen
dc.identifier.vol25en
dc.identifier.iss2en


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