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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

dc.contributor.authorNtalla, Ioanna
dc.contributor.authorWeng, Lu-Chen
dc.contributor.authorCartwright, James H
dc.contributor.authorHall, Amelia Weber
dc.contributor.authorSveinbjornsson, Gardar
dc.contributor.authorTucker, Nathan R
dc.contributor.authorChoi, Seung Hoan
dc.contributor.authorChaffin, Mark D
dc.contributor.authorRoselli, Carolina
dc.contributor.authorBarnes, Michael R
dc.contributor.authorMifsud, Borbala
dc.contributor.authorWarren, Helen R
dc.contributor.authorHayward, Caroline
dc.contributor.authorMarten, Jonathan
dc.contributor.authorCranley, James J
dc.contributor.authorConcas, Maria Pina
dc.contributor.authorGasparini, Paolo
dc.contributor.authorBoutin, Thibaud
dc.contributor.authorKolcic, Ivana
dc.contributor.authorPolasek, Ozren
dc.contributor.authorRudan, Igor
dc.contributor.authorAraujo, Nathalia M
dc.contributor.authorLima-Costa, Maria Fernanda
dc.contributor.authorRibeiro, Antonio Luiz P
dc.contributor.authorSouza, Renan P
dc.contributor.authorTarazona-Santos, Eduardo
dc.contributor.authorGiedraitis, Vilmantas
dc.contributor.authorIngelsson, Erik
dc.contributor.authorMahajan, Anubha
dc.contributor.authorMorris, Andrew P
dc.contributor.authorDel Greco M, Fabiola
dc.contributor.authorFoco, Luisa
dc.contributor.authorGögele, Martin
dc.contributor.authorHicks, Andrew A
dc.contributor.authorCook, James P
dc.contributor.authorLind, Lars
dc.contributor.authorLindgren, Cecilia M
dc.contributor.authorSundström, Johan
dc.contributor.authorNelson, Christopher P
dc.contributor.authorRiaz, Muhammad B
dc.contributor.authorSamani, Nilesh J
dc.contributor.authorSinagra, Gianfranco
dc.contributor.authorUlivi, Sheila
dc.contributor.authorKähönen, Mika
dc.contributor.authorMishra, Pashupati P
dc.contributor.authorMononen, Nina
dc.contributor.authorNikus, Kjell
dc.contributor.authorCaulfield, Mark J
dc.contributor.authorDominiczak, Anna
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorMontasser, May E
dc.contributor.authorO'Connell, Jeff R
dc.contributor.authorRyan, Kathleen
dc.contributor.authorShuldiner, Alan R
dc.contributor.authorAeschbacher, Stefanie
dc.contributor.authorConen, David
dc.contributor.authorRisch, Lorenz
dc.contributor.authorThériault, Sébastien
dc.contributor.authorHutri-Kähönen, Nina
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorBarnes, Catriona L K
dc.contributor.authorCampbell, Harry
dc.contributor.authorJoshi, Peter K
dc.contributor.authorWilson, James F
dc.contributor.authorIsaacs, Aaron
dc.contributor.authorKors, Jan A
dc.contributor.authorvan Duijn, Cornelia M
dc.contributor.authorHuang, Paul L
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHarris, Tamara B
dc.contributor.authorLauner, Lenore J
dc.contributor.authorSmith, Albert V
dc.contributor.authorBottinger, Erwin P
dc.contributor.authorLoos, Ruth J F
dc.contributor.authorNadkarni, Girish N
dc.contributor.authorPreuss, Michael H
dc.contributor.authorCorrea, Adolfo
dc.contributor.authorMei, Hao
dc.contributor.authorWilson, James
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorMüller-Nurasyid, Martina
dc.contributor.authorPeters, Annette
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorMangino, Massimo
dc.contributor.authorSpector, Timothy D
dc.contributor.authorRienstra, Michiel
dc.contributor.authorvan de Vegte, Yordi J
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorVerweij, Niek
dc.contributor.authorKääb, Stefan
dc.contributor.authorSchramm, Katharina
dc.contributor.authorSinner, Moritz F
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorCutler, Michael J
dc.contributor.authorFatkin, Diane
dc.contributor.authorLondon, Barry
dc.contributor.authorOlesen, Morten
dc.contributor.authorRoden, Dan M
dc.contributor.authorBenjamin Shoemaker, M
dc.contributor.authorGustav Smith, J
dc.contributor.authorBiggs, Mary L
dc.contributor.authorBis, Joshua C
dc.contributor.authorBrody, Jennifer A
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorRice, Kenneth
dc.contributor.authorSotoodehnia, Nona
dc.contributor.authorDe Grandi, Alessandro
dc.contributor.authorFuchsberger, Christian
dc.contributor.authorPattaro, Cristian
dc.contributor.authorPramstaller, Peter P
dc.contributor.authorFord, Ian
dc.contributor.authorWouter Jukema, J
dc.contributor.authorMacfarlane, Peter W
dc.contributor.authorTrompet, Stella
dc.contributor.authorDörr, Marcus
dc.contributor.authorFelix, Stephan B
dc.contributor.authorVölker, Uwe
dc.contributor.authorWeiss, Stefan
dc.contributor.authorHavulinna, Aki S
dc.contributor.authorJula, Antti
dc.contributor.authorSääksjärvi, Katri
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorHeckbert, Susan R
dc.contributor.authorLin, Henry J
dc.contributor.authorRotter, Jerome I
dc.contributor.authorTaylor, Kent D
dc.contributor.authorYao, Jie
dc.contributor.authorde Mutsert, Renée
dc.contributor.authorMaan, Arie C
dc.contributor.authorMook-Kanamori, Dennis O
dc.contributor.authorNoordam, Raymond
dc.contributor.authorCucca, Francesco
dc.contributor.authorDing, Jun
dc.contributor.authorLakatta, Edward G
dc.contributor.authorQian, Yong
dc.contributor.authorTarasov, Kirill V
dc.contributor.authorLevy, Daniel
dc.contributor.authorLin, Honghuang
dc.contributor.authorNewton-Cheh, Christopher H
dc.contributor.authorLunetta, Kathryn L
dc.contributor.authorMurray, Alison D
dc.contributor.authorPorteous, David J
dc.contributor.authorSmith, Blair H
dc.contributor.authorStricker, Bruno H
dc.contributor.authorUitterlinden, André
dc.contributor.authorvan den Berg, Marten E
dc.contributor.authorHaessler, Jeffrey
dc.contributor.authorJackson, Rebecca D
dc.contributor.authorKooperberg, Charles
dc.contributor.authorPeters, Ulrike
dc.contributor.authorReiner, Alexander P
dc.contributor.authorWhitsel, Eric A
dc.contributor.authorAlonso, Alvaro
dc.contributor.authorArking, Dan E
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorEhret, Georg B
dc.contributor.authorSoliman, Elsayed Z
dc.contributor.authorAvery, Christy L
dc.contributor.authorGogarten, Stephanie M
dc.contributor.authorKerr, Kathleen F
dc.contributor.authorLaurie, Cathy C
dc.contributor.authorSeyerle, Amanda A
dc.contributor.authorStilp, Adrienne
dc.contributor.authorAssa, Solmaz
dc.contributor.authorAbdullah Said, M
dc.contributor.authorYldau van der Ende, M
dc.contributor.authorLambiase, Pier D
dc.contributor.authorOrini, Michele
dc.contributor.authorRamirez, Julia
dc.contributor.authorVan Duijvenboden, Stefan
dc.contributor.authorArnar, David O
dc.contributor.authorGudbjartsson, Daniel F
dc.contributor.authorHolm, Hilma
dc.contributor.authorSulem, Patrick
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorThorolfsdottir, Rosa B
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorBenjamin, Emelia J
dc.contributor.authorTinker, Andrew
dc.contributor.authorStefansson, Kari
dc.contributor.authorEllinor, Patrick T
dc.contributor.authorJamshidi, Yalda
dc.contributor.authorLubitz, Steven A
dc.contributor.authorMunroe, Patricia B
dc.date.accessioned2020-06-29T16:40:01Z
dc.date.available2020-06-29T16:40:01Z
dc.date.issued2020-05-21
dc.identifier.citationNtalla , I , Weng , L-C , Cartwright , J H , Hall , A W , Sveinbjornsson , G , Tucker , N R , Choi , S H , Chaffin , M D , Roselli , C , Barnes , M R , Mifsud , B , Warren , H R , Hayward , C , Marten , J , Cranley , J J , Concas , M P , Gasparini , P , Boutin , T , Kolcic , I , Polasek , O , Rudan , I , Araujo , N M , Lima-Costa , M F , Ribeiro , A L P , Souza , R P , Tarazona-Santos , E , Giedraitis , V , Ingelsson , E , Mahajan , A , Morris , A P , Del Greco M , F , Foco , L , Gögele , M , Hicks , A A , Cook , J P , Lind , L , Lindgren , C M , Sundström , J , Nelson , C P , Riaz , M B , Samani , N J , Sinagra , G , Ulivi , S , Kähönen , M , Mishra , P P , Mononen , N , Nikus , K , Caulfield , M J , Dominiczak , A , Padmanabhan , S , Montasser , M E , O'Connell , J R , Ryan , K , Shuldiner , A R , Aeschbacher , S , Conen , D , Risch , L , Thériault , S , Hutri-Kähönen , N , Lehtimäki , T , Lyytikäinen , L-P , Raitakari , O T , Barnes , C L K , Campbell , H , Joshi , P K , Wilson , J F , Isaacs , A , Kors , J A , van Duijn , C M , Huang , P L , Gudnason , V , Harris , T B , Launer , L J , Smith , A V , Bottinger , E P , Loos , R J F , Nadkarni , G N , Preuss , M H , Correa , A , Mei , H , Wilson , J , Meitinger , T , Müller-Nurasyid , M , Peters , A , Waldenberger , M , Mangino , M , Spector , T D , Rienstra , M , van de Vegte , Y J , van der Harst , P , Verweij , N , Kääb , S , Schramm , K , Sinner , M F , Strauch , K , Cutler , M J , Fatkin , D , London , B , Olesen , M , Roden , D M , Benjamin Shoemaker , M , Gustav Smith , J , Biggs , M L , Bis , J C , Brody , J A , Psaty , B M , Rice , K , Sotoodehnia , N , De Grandi , A , Fuchsberger , C , Pattaro , C , Pramstaller , P P , Ford , I , Wouter Jukema , J , Macfarlane , P W , Trompet , S , Dörr , M , Felix , S B , Völker , U , Weiss , S , Havulinna , A S , Jula , A , Sääksjärvi , K , Salomaa , V , Guo , X , Heckbert , S R , Lin , H J , Rotter , J I , Taylor , K D , Yao , J , de Mutsert , R , Maan , A C , Mook-Kanamori , D O , Noordam , R , Cucca , F , Ding , J , Lakatta , E G , Qian , Y , Tarasov , K V , Levy , D , Lin , H , Newton-Cheh , C H , Lunetta , K L , Murray , A D , Porteous , D J , Smith , B H , Stricker , B H , Uitterlinden , A , van den Berg , M E , Haessler , J , Jackson , R D , Kooperberg , C , Peters , U , Reiner , A P , Whitsel , E A , Alonso , A , Arking , D E , Boerwinkle , E , Ehret , G B , Soliman , E Z , Avery , C L , Gogarten , S M , Kerr , K F , Laurie , C C , Seyerle , A A , Stilp , A , Assa , S , Abdullah Said , M , Yldau van der Ende , M , Lambiase , P D , Orini , M , Ramirez , J , Van Duijvenboden , S , Arnar , D O , Gudbjartsson , D F , Holm , H , Sulem , P , Thorleifsson , G , Thorolfsdottir , R B , Thorsteinsdottir , U , Benjamin , E J , Tinker , A , Stefansson , K , Ellinor , P T , Jamshidi , Y , Lubitz , S A & Munroe , P B 2020 , ' Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction ' , Nature Communications , vol. 11 , 2542 . https://doi.org/10.1038/s41467-020-15706-xen
dc.identifier.issn2041-1723
dc.identifier.otherPURE: 159502023
dc.identifier.otherPURE UUID: daee48ed-8897-47c2-b7fd-70b73e2944ad
dc.identifier.otherPubMed: 32439900
dc.identifier.otherPubMed: 32439900
dc.identifier.otherPubMedCentral: PMC7242331
dc.identifier.otherScopus: 85085157192
dc.identifier.otherWOS: 000537067700001
dc.identifier.urihttps://hdl.handle.net/2164/14604
dc.descriptionAcknowledgements We provide all investigator and study-specific acknowledgements in Supplementary Note 1, and funding sources in Supplementary Note 2.en
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectcardiovascular diseasesen
dc.subjectcardiovascular geneticsen
dc.subjectgenome-wide association studiesen
dc.subjectCARDIOMYOPATHYen
dc.subjectDECREASEen
dc.subjectRISKen
dc.subjectBRADYCARDIAen
dc.subjectATRIAL-FIBRILLATIONen
dc.subjectELEMENTSen
dc.subjectCALCINEURINen
dc.subjectMUTATIONSen
dc.subjectDURATIONen
dc.subjectGENOME-WIDE ASSOCIATIONen
dc.subjectR Medicineen
dc.subjectPhysics and Astronomy(all)en
dc.subjectChemistry(all)en
dc.subjectBiochemistry, Genetics and Molecular Biology(all)en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleMulti-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conductionen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1038/s41467-020-15706-x
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85085157192&partnerID=8YFLogxKen
dc.identifier.vol11en


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