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Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance

dc.contributor.authorKang, Eunchai
dc.contributor.authorSong, Juan
dc.contributor.authorLin, Yuting
dc.contributor.authorPark, Jaesuk
dc.contributor.authorLee, Jennifer H.
dc.contributor.authorHussani, Qassim
dc.contributor.authorGu, Yan
dc.contributor.authorGe, Shaoyu
dc.contributor.authorLi, Weidong
dc.contributor.authorHsu, Kuei-sen
dc.contributor.authorBerninger, Benedikt
dc.contributor.authorChristian, Kimberly M.
dc.contributor.authorSong, Hongjun
dc.contributor.authorMing, Guo-li
dc.date.accessioned2020-07-27T11:35:01Z
dc.date.available2020-07-27T11:35:01Z
dc.date.issued2019-08-06
dc.identifier.citationKang , E , Song , J , Lin , Y , Park , J , Lee , J H , Hussani , Q , Gu , Y , Ge , S , Li , W , Hsu , K , Berninger , B , Christian , K M , Song , H & Ming , G 2019 , ' Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance ' , Cell Reports , vol. 28 , no. 6 , pp. 1419-1428.e3 . https://doi.org/10.1016/j.celrep.2019.07.024en
dc.identifier.issn2211-1247
dc.identifier.otherPURE: 163811857
dc.identifier.otherPURE UUID: f8a56764-8019-4761-9a7b-edbc7a34284e
dc.identifier.otherScopus: 85069820573
dc.identifier.otherPubMed: 31390557
dc.identifier.otherORCID: /0000-0001-6884-622X/work/78070589
dc.identifier.urihttps://hdl.handle.net/2164/14779
dc.descriptionAcknowledgments: We thank members of the Ming and Song laboratories for comments and suggestions, D. Johnson for technical support, and J. Schnoll for lab coordination. This work was supported by grants from the National Institutes of Health (NIH) (R01MH105128 and R35NS097370 to G.-L.M. and R37NS047344 to H.S.) and from the National Alliance for Research on Schizophrenia and Depression (NARSAD) to G.-L.M., H.S., and E.K. Author Contributions: E.K. and J.S contributed equally to this work. J.S. performed electrophysiological analysis and E.K. performed morphological analysis. Y.L. and K.-S.H. contributed to electrophysiology data collection, Y.G. and S.G. helped with some of the retrovirus production, and B.B. helped with rabies synaptic tracing. J.P., J.H.L., Q.H., W.L., and K.M.C. contributed to additional data collection. E.K., J.S., H.S., and G-L.M. designed the project and wrote the manuscript.en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofCell Reportsen
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectcircuit developmenten
dc.subjectdepolarizing GABAen
dc.subjectDISC1en
dc.subjectexcitation/inhibition imbalanceen
dc.subjectGABA polarity switchen
dc.subjectGABA signalingen
dc.subjecthomeostasisen
dc.subjectmental disorderen
dc.subjectParvalbumin interneuronen
dc.subjectsynapse formationen
dc.subjectR Medicine (General)en
dc.subjectBiochemistry, Genetics and Molecular Biology(all)en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleInterplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalanceen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2019.07.024
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85069820573&partnerID=8YFLogxKen
dc.identifier.vol28en
dc.identifier.iss6en


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