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Association between COPD exacerbations and lung function decline during maintenance therapy

dc.contributor.authorKerkhof, Marjan
dc.contributor.authorVoorham, Jaco
dc.contributor.authorDorinsky, Paul
dc.contributor.authorCabrera, Claudia
dc.contributor.authorDarken, Patrick
dc.contributor.authorKocks, Janwillem WH
dc.contributor.authorSadatsafavi, Mohsen
dc.contributor.authorSin, Don D.
dc.contributor.authorCarter, Victoria
dc.contributor.authorPrice, David B.
dc.date.accessioned2020-08-18T10:50:00Z
dc.date.available2020-08-18T10:50:00Z
dc.date.issued2020-09-30
dc.identifier.citationKerkhof , M , Voorham , J , Dorinsky , P , Cabrera , C , Darken , P , Kocks , J WH , Sadatsafavi , M , Sin , D D , Carter , V & Price , D B 2020 , ' Association between COPD exacerbations and lung function decline during maintenance therapy ' , Thorax , vol. 75 , no. 9 , pp. 744-753 . https://doi.org/10.1136/thoraxjnl-2019-214457en
dc.identifier.issn0040-6376
dc.identifier.otherPURE: 170264444
dc.identifier.otherPURE UUID: adacb42d-0564-4392-9e68-8c6239881766
dc.identifier.otherPubMed: 32532852
dc.identifier.otherScopus: 85086718934
dc.identifier.otherWOS: 000566530300007
dc.identifier.urihttps://hdl.handle.net/2164/14945
dc.descriptionAcknowledgements: Writing and editorial support was provided by Dr Julia Granerod, supported by the Observational and Pragmatic Research Institute Pte. Ltd (OPRI). Funding: This study was funded by AstraZeneca.Data availability statement: Data may be obtained from a third party and are not publicly available. The dataset supporting the conclusions of this article was derived from the Clinical Practice Research Datalink (www.cprd.com) and the Optimum Patient Care Research Database (www.opcrd.co.uk). The CPRD has broad National Research Ethics Service Committee (NRES) ethics approval for purely observational research using the primary care data and established data linkages. The OPCRD has ethical approval from the National Health Service (NHS) Research Authority to hold and process anonymised research data (Research Ethics Committee reference: 5/EM/0150). This study was approved by the Anonymised Data Ethics Protocols and Transparency (ADEPT) committee – the independent scientific advisory committee for the OPCRD, and the Independent Scientific Advisory Committee (ISAC) for the CPRD. The authors do not have permission to give public access to the study dataset; researchers may request access to CPRD or OPCRD data for their own purposes. Access to CPRD can be made via the CPRD website (https://www.cprd.com/researcher/) or via the enquiries email enquiries@cprd. com. Access to OCPRD can be made via the OCPRD website(https://opcrd.co.uk/our-database/data-requests/) or via the enquiries email info@opcrd.co.uk. The study was designed, implemented, and registered in accordance with the criteria of the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (EUPAS19879).en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofThoraxen
dc.rights© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.en
dc.subjectCOPD exacerbationsen
dc.subjectCOPD pharmacologyen
dc.subjecteosinophil biologyen
dc.subjectlung physiologyen
dc.subjectOBSTRUCTIVE PULMONARY-DISEASEen
dc.subjectIMPACTen
dc.subjectBIOMARKERen
dc.subjectBLOOD EOSINOPHILSen
dc.subjectINHALED CORTICOSTEROIDSen
dc.subjectFEV1 DECLINEen
dc.subjectR Medicine (General)en
dc.subjectPulmonary and Respiratory Medicineen
dc.subject.lccR1en
dc.titleAssociation between COPD exacerbations and lung function decline during maintenance therapyen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1136/thoraxjnl-2019-214457
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85086718934&partnerID=8YFLogxKen
dc.identifier.vol75en
dc.identifier.iss9en


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