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In vivo modulation of cervicovaginal drug transporters and tissue distribution by film-released tenofovir and darunavir for topical prevention of HIV-1

dc.contributor.authorHijazi, Karolin
dc.contributor.authorIannelli, Francesco
dc.contributor.authorCuppone, Anna Maria
dc.contributor.authorDesjardins, Delphine
dc.contributor.authorCaldwell, Anna
dc.contributor.authorDereuddre-Bosquet, Nathalie
dc.contributor.authorScala, Carlo
dc.contributor.authorSmith, Kieron A
dc.contributor.authorMukhopadya, Indrani
dc.contributor.authorFrank, Bruce
dc.contributor.authorGwozdz, Garry
dc.contributor.authorSantoro, Francesco
dc.contributor.authorLe Grand, Roger
dc.contributor.authorPozzi, Gianni
dc.contributor.authorKelly, Charles G
dc.date.accessioned2021-02-04T00:08:12Z
dc.date.available2021-02-04T00:08:12Z
dc.date.issued2020-03-02
dc.identifier.citationHijazi , K , Iannelli , F , Cuppone , A M , Desjardins , D , Caldwell , A , Dereuddre-Bosquet , N , Scala , C , Smith , K A , Mukhopadya , I , Frank , B , Gwozdz , G , Santoro , F , Le Grand , R , Pozzi , G & Kelly , C G 2020 , ' In vivo modulation of cervicovaginal drug transporters and tissue distribution by film-released tenofovir and darunavir for topical prevention of HIV-1 ' , Molecular Pharmaceutics , vol. 17 , no. 3 , pp. 852-864 . https://doi.org/10.1021/acs.molpharmaceut.9b01121en
dc.identifier.issn1543-8384
dc.identifier.otherPURE: 156647375
dc.identifier.otherPURE UUID: dca6dff7-1fa5-452f-85c4-61a18e849990
dc.identifier.otherScopus: 85080093342
dc.identifier.otherWOS: 000518088600013
dc.identifier.urihttps://hdl.handle.net/2164/15775
dc.descriptionWe thank Gilead Science for provision of tenofovir and Janssen R&D Ireland for provision of darunavir. We thank members of the MOTIF consortium for useful discussions and exchange of ideas during the course of this study. We thank the technical staff of IDMIT, the animal care and veterinary staff at CEA, Fontenay-aux-Roses, France. Funding: this work was supported by the European Union's Seventh Programme for research, technological development and demonstration under grant agreement No 305316 as part of the MOTIF (Microbicides Formulation Through Innovative Formulation for Vaginal and Rectal Delivery) project. It has also the support of the “Investissements d’Avenir” French government program managed by the Agence Nationale de la Recherche under ANR-11-INBS-0008 funding for the Infectious Disease Models and Innovative Therapies (IDMIT, Fontenay-aux-Roses, France) infrastructure, and ANR-10-EQPX-02-01 funding for the FlowCyTech facility (IDMIT, Fontenay-aux-Roses, France).en
dc.format.extent13
dc.language.isoeng
dc.relation.ispartofMolecular Pharmaceuticsen
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.molpharmaceut.9b01121en
dc.subjectMultidrug resistance associated proteinen
dc.subjecttenofoviren
dc.subjectdarunaviren
dc.subjectmicrobicidesen
dc.subjectvaginaen
dc.subjectmacaquesen
dc.subjectmultidrug resistance associated proteinen
dc.subjectCELLSen
dc.subjectPROTEASE INHIBITORSen
dc.subjectP-GLYCOPROTEINen
dc.subjectVAGINAL RINGSen
dc.subjectEFFLUX TRANSPORTERSen
dc.subjectREVERSE-TRANSCRIPTASE INHIBITORSen
dc.subjectDISOPROXIL FUMARATEen
dc.subjectINTRACELLULAR ACCUMULATIONen
dc.subjectMULTIDRUG-RESISTANCEen
dc.subjectEXPRESSIONen
dc.subjectR Medicineen
dc.subjectDrug Discoveryen
dc.subjectMolecular Medicineen
dc.subjectPharmaceutical Scienceen
dc.subjectEuropean Commissionen
dc.subject305316en
dc.subjectSupplementary data availableen
dc.subject.lccRen
dc.titleIn vivo modulation of cervicovaginal drug transporters and tissue distribution by film-released tenofovir and darunavir for topical prevention of HIV-1en
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Dental Educationen
dc.contributor.institutionUniversity of Aberdeen.Clinical Medicineen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPostprinten
dc.identifier.doihttps://doi.org/10.1021/acs.molpharmaceut.9b01121
dc.date.embargoedUntil2021-02-04
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85080093342&partnerID=8YFLogxKen


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