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dc.contributor.authorLi , Zhixiu
dc.contributor.authorWu , Xin
dc.contributor.authorLeo , Paul J.
dc.contributor.authorde Guzman, Erika
dc.contributor.authorAkkoc, Nurullah
dc.contributor.authorBreban, Maxime
dc.contributor.authorMacfarlane, Gary
dc.contributor.authorMahmoudi, Mahdi
dc.contributor.authorMarzo-Ortega, Helena
dc.contributor.authorAnderson, Lisa
dc.contributor.authorWheeler, Lawrie
dc.contributor.authorChou, Chung-Tei
dc.contributor.authorHarrison , Andrew A.
dc.contributor.authorStebbings , Simon
dc.contributor.authorJones, Gareth
dc.contributor.authorBang, So-Young
dc.contributor.authorWang, Geng
dc.contributor.authorJamshidi, Ahmadreza
dc.contributor.authorFarhadi, Elham
dc.contributor.authorSong, Jing
dc.contributor.authorLin, Li
dc.contributor.authorLi, Mengmeng
dc.contributor.authorCheng-Chung Wei, James
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorWright, Margaret J.
dc.contributor.authorLee, MinJae
dc.contributor.authorWang, Yuqin
dc.contributor.authorZhan, Jian
dc.contributor.authorZhang, Jin-San
dc.contributor.authorWang, Xiaobing
dc.contributor.authorJin , Zi-Bing
dc.contributor.authorWeisman, Michael H.
dc.contributor.authorGensler, Lianne S.
dc.contributor.authorWard, Michael M.
dc.contributor.authorRahbar, Mohammad H.
dc.contributor.authorDiekman, Laura
dc.contributor.authorKim, Tae-Hwan
dc.contributor.authorReveille, John D.
dc.contributor.authorWordsworth, B. Paul
dc.contributor.authorXu , Huji
dc.contributor.authorBrown , Matthew A.
dc.date.accessioned2021-03-30T14:00:01Z
dc.date.available2021-03-30T14:00:01Z
dc.date.issued2021-08-12
dc.identifier.citationLi , Z , Wu , X , Leo , P J , de Guzman , E , Akkoc , N , Breban , M , Macfarlane , G , Mahmoudi , M , Marzo-Ortega , H , Anderson , L , Wheeler , L , Chou , C-T , Harrison , A A , Stebbings , S , Jones , G , Bang , S-Y , Wang , G , Jamshidi , A , Farhadi , E , Song , J , Lin , L , Li , M , Cheng-Chung Wei , J , Martin , N G , Wright , M J , Lee , M , Wang , Y , Zhan , J , Zhang , J-S , Wang , X , Jin , Z-B , Weisman , M H , Gensler , L S , Ward , M M , Rahbar , M H , Diekman , L , Kim , T-H , Reveille , J D , Wordsworth , B P , Xu , H & Brown , M A 2021 , ' Polygenic risk scores have high diagnostic capacity in ankylosing spondylitis ' , Annals of the Rheumatic Diseases , vol. 80 , no. 9 , annrheumdis-2020-219446 , pp. 1168-1174 . https://doi.org/10.1136/annrheumdis-2020-219446en
dc.identifier.issn0003-4967
dc.identifier.otherPURE: 190693465
dc.identifier.otherPURE UUID: 97b4d28e-a064-42f1-87ab-a84ceaaa1d19
dc.identifier.otherORCID: /0000-0003-2322-3314/work/94083582
dc.identifier.otherORCID: /0000-0003-0016-7591/work/94084261
dc.identifier.otherScopus: 85104835828
dc.identifier.otherPubMed: 34161253
dc.identifier.otherJisc: 9d9153efd9b64060a1844eb7c984272b
dc.identifier.otherWOS: 000686232600026
dc.identifier.urihttps://hdl.handle.net/2164/16156
dc.descriptionWe would like to thank all participating subjects with AS and healthy individuals who provided the DNA and clinical information necessary for this study. The TASC study was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) grants P01-052915, R01-AR046208. Funding was also received from the University of Texas Health Science Center at Houston CTSA grant UL1RR02418, Cedars-Sinai GCRC grant MO1-RR00425, Intramural Research Program, NIAMS/NIH, and Rebecca Cooper Foundation (Australia). This study was funded, in part, by Arthritis Research UK (Grants 19536 and 18797), by the Wellcome Trust (grant number 076113), and by the Oxford Comprehensive Biomedical Research Centre ankylosing spondylitis chronic disease cohort (Theme Code: A91202). JZB was funded by a grant from the Zhejiang Provincial Natural Science Foundation of China (LD18H120001LD). The New Zealand data was derived from participants in the Spondyloarthritis Genetics and the Environment Study (SAGE) and was funded by The Health Research Council, New Zealand. HX was funded by the National Natural Science Foundation of China (Grant 81430031) and China Ministry of Science and Technology (973 Program of China 2014CB541800). We acknowledge the Understanding Society: The UK Household Longitudinal Study. This is led by the Institute for Social and Economic Research at the University of Essex and funded by the Economic and Social Research Council. The survey was conducted by NatCen and the genome-wide scan data were analysed and deposited by the Wellcome Trust Sanger Institute. Information on how to access the data can be found on the Understanding Society website https: www.understandingsociety.ac.uk/. French sample collection was performed by the Groupe Française d’Etude Génétique des Spondylarthrites, coordinated by Professor Maxime Breban and funded by the Agence Nationale de Recherche GEMISA grant reference ANR-10-MIDI-0002. We acknowledge and thank the TCRI AS Group for their support in recruiting patients for the study (see below). The authors acknowledge the sharing of data and samples by the BSRBR-AS Register in Aberdeen. Chief Investigator, Prof Gary Macfarlane and Dr. Gareth Jones, Deputy Chief Investigator created the BSRBR-AS study which was commissioned by the British Society for Rheumatology, funded in part by Abbvie, Pfizer and UCB. We are grateful to every patient, past and present staff of the BSRBR-AS register team and to all clinical staff who recruited patients, followed them up and entered data – details here: https://www.abdn.ac.uk/iahs/research/epidemiology/spondyloarthritis.php#panel1011. The QIMR control samples were from parents of adolescent twins collected in the context of the Brisbane Longitudinal Twin Study 1992–2016, support by grants from NHMRC (NGM) and ARC (MJW). We thank Anjali Henders, Lisa Bowdler, Tabatha Goncales for biobank collection and Kerrie McAloney and Scott Gordon for curating samples for this study. MAB is funded by a National Health and Medical Research Council (Australia) Senior Principal Research Fellowship (1024879), and support for this study was received from a National Health and Medical Research Council (Australia) program grant (566938) and project grant (569829), and from the Australian Cancer Research Foundation and Rebecca Cooper Medical Research Foundation. We are also very grateful for the invaluable support received from the National Ankylosing Spondylitis Society (UK) and Spondyloarthritis Association of America in case recruitment. Additional financial and technical support for patient recruitment was provided by the National Institute for Health Research Oxford Musculoskeletal Biomedical Research Unit and NIHR Thames Valley Comprehensive Local Research and an unrestricted educational grant from Abbott Laboratories. This research was funded/supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London and/or the NIHR Clinical Research Facility. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofAnnals of the Rheumatic Diseasesen
dc.rights© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.en
dc.subjectAnkylosing spondylitisen
dc.subjectPolygenic risk scoreen
dc.subjectHLA-B27en
dc.subjectCRPen
dc.subjectMRIen
dc.subjectImmunologyen
dc.subjectGeneral Biochemistry, Genetics and Molecular Biologyen
dc.subjectImmunology and Allergyen
dc.subjectRheumatologyen
dc.subjectR Medicineen
dc.subjectArthritis Research UK (ARUK)en
dc.subject19536en
dc.subject18797en
dc.subjectWellcome Trusten
dc.subject076113en
dc.subjectOtheren
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titlePolygenic risk scores have high diagnostic capacity in ankylosing spondylitisen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Epidemiology Groupen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)en
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1136/annrheumdis-2020-219446
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85104835828&partnerID=8YFLogxKen


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