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Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes

dc.contributor.authorMazzon, Michela
dc.contributor.authorCastro, Cecilia
dc.contributor.authorThaa, Bastian
dc.contributor.authorLiu, Lifeng
dc.contributor.authorMutso, Margit
dc.contributor.authorLiu, Xiang
dc.contributor.authorMahalingam, Suresh
dc.contributor.authorGriffin, Julian L
dc.contributor.authorMarsh, Mark
dc.contributor.authorMcInerney, Gerald M
dc.date.accessioned2021-11-26T10:34:01Z
dc.date.available2021-11-26T10:34:01Z
dc.date.issued2018-01-29
dc.identifier.citationMazzon , M , Castro , C , Thaa , B , Liu , L , Mutso , M , Liu , X , Mahalingam , S , Griffin , J L , Marsh , M & McInerney , G M 2018 , ' Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes ' , PLoS Pathogens , vol. 14 , no. 1 , e1006835 . https://doi.org/10.1371/journal.ppat.1006835en
dc.identifier.issn1553-7366
dc.identifier.otherPURE: 197054477
dc.identifier.otherPURE UUID: 5b033bae-e5be-4059-8d0c-9a4a76347536
dc.identifier.otherPubMed: 29377936
dc.identifier.otherPubMedCentral: PMC5805360
dc.identifier.otherScopus: 85041678829
dc.identifier.otherORCID: /0000-0003-1336-7744/work/98038723
dc.identifier.urihttps://hdl.handle.net/2164/17568
dc.descriptionAcknowledgments We thank our MRC-LMCB colleagues Dr Chiara Mencarelli who provided the rat cortical neurons used in this study, Dr Christin Luft for help with acquisition of high-content confocal images, and Dr Janos Kriston-Vizi for help with Fiji software. Dr Scott Lawrence kindly provided the SH-SY5Y cells. We thank Prof Andres Merits (University of Tartu, Estonia) for provision of nsP3 antibody and Dr Ji Luo (National Cancer Institute, USA) for provision of p85 expression plasmids.en
dc.format.extent22
dc.language.isoeng
dc.relation.ispartofPLoS Pathogensen
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectAlphavirus/pathogenicityen
dc.subjectAlphavirus Infections/metabolismen
dc.subjectAnimalsen
dc.subjectCells, Cultureden
dc.subjectCricetinaeen
dc.subjectEnzyme Activationen
dc.subjectGlucose/metabolismen
dc.subjectGlycolysis/physiologyen
dc.subjectHEK293 Cellsen
dc.subjectHost-Pathogen Interactionsen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectMice, Inbred C57BLen
dc.subjectPhosphatidylinositol 3-Kinases/metabolismen
dc.subjectProto-Oncogene Proteins c-akt/metabolismen
dc.subjectRoss River virus/physiologyen
dc.subjectSemliki forest virus/physiologyen
dc.subjectVirulenceen
dc.subjectQR355 Virologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_UU_12018/1en
dc.subjectMC_UP_A090_1006en
dc.subjectSupplementary Informationen
dc.subject.lccQR355en
dc.titleAlphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1371/journal.ppat.1006835
dc.identifier.vol14en
dc.identifier.iss1en


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