dc.contributor.author | Mazzon, Michela | |
dc.contributor.author | Castro, Cecilia | |
dc.contributor.author | Thaa, Bastian | |
dc.contributor.author | Liu, Lifeng | |
dc.contributor.author | Mutso, Margit | |
dc.contributor.author | Liu, Xiang | |
dc.contributor.author | Mahalingam, Suresh | |
dc.contributor.author | Griffin, Julian L | |
dc.contributor.author | Marsh, Mark | |
dc.contributor.author | McInerney, Gerald M | |
dc.date.accessioned | 2021-11-26T10:34:01Z | |
dc.date.available | 2021-11-26T10:34:01Z | |
dc.date.issued | 2018-01-29 | |
dc.identifier.citation | Mazzon , M , Castro , C , Thaa , B , Liu , L , Mutso , M , Liu , X , Mahalingam , S , Griffin , J L , Marsh , M & McInerney , G M 2018 , ' Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes ' , PLoS Pathogens , vol. 14 , no. 1 , e1006835 . https://doi.org/10.1371/journal.ppat.1006835 | en |
dc.identifier.issn | 1553-7366 | |
dc.identifier.other | PURE: 197054477 | |
dc.identifier.other | PURE UUID: 5b033bae-e5be-4059-8d0c-9a4a76347536 | |
dc.identifier.other | PubMed: 29377936 | |
dc.identifier.other | PubMedCentral: PMC5805360 | |
dc.identifier.other | Scopus: 85041678829 | |
dc.identifier.other | ORCID: /0000-0003-1336-7744/work/98038723 | |
dc.identifier.uri | https://hdl.handle.net/2164/17568 | |
dc.description | Acknowledgments We thank our MRC-LMCB colleagues Dr Chiara Mencarelli who provided the rat cortical neurons used in this study, Dr Christin Luft for help with acquisition of high-content confocal images, and Dr Janos Kriston-Vizi for help with Fiji software. Dr Scott Lawrence kindly provided the SH-SY5Y cells. We thank Prof Andres Merits (University of Tartu, Estonia) for provision of nsP3 antibody and Dr Ji Luo (National Cancer Institute, USA) for provision of p85 expression plasmids. | en |
dc.format.extent | 22 | |
dc.language.iso | eng | |
dc.relation.ispartof | PLoS Pathogens | en |
dc.rights | This is an open access article distributed under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.subject | Alphavirus/pathogenicity | en |
dc.subject | Alphavirus Infections/metabolism | en |
dc.subject | Animals | en |
dc.subject | Cells, Cultured | en |
dc.subject | Cricetinae | en |
dc.subject | Enzyme Activation | en |
dc.subject | Glucose/metabolism | en |
dc.subject | Glycolysis/physiology | en |
dc.subject | HEK293 Cells | en |
dc.subject | Host-Pathogen Interactions | en |
dc.subject | Humans | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Phosphatidylinositol 3-Kinases/metabolism | en |
dc.subject | Proto-Oncogene Proteins c-akt/metabolism | en |
dc.subject | Ross River virus/physiology | en |
dc.subject | Semliki forest virus/physiology | en |
dc.subject | Virulence | en |
dc.subject | QR355 Virology | en |
dc.subject | Medical Research Council (MRC) | en |
dc.subject | MC_UU_12018/1 | en |
dc.subject | MC_UP_A090_1006 | en |
dc.subject | Supplementary Information | en |
dc.subject.lcc | QR355 | en |
dc.title | Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes | en |
dc.type | Journal article | en |
dc.contributor.institution | University of Aberdeen.Rowett Institute | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Publisher PDF | en |
dc.identifier.doi | https://doi.org/10.1371/journal.ppat.1006835 | |
dc.identifier.vol | 14 | en |
dc.identifier.iss | 1 | en |