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TGFb2 induces the soluble isoform of CTLA-4 – implications for CTLA-4 based checkpoint inhibitor antibodies in malignant melanoma

dc.contributor.authorKhanolkar, Rahul Chaitanya
dc.contributor.authorZhang, Chu
dc.contributor.authoral-Fatyan, Farah
dc.contributor.authorLawson, Linda G
dc.contributor.authorDepasquale, Ivan
dc.contributor.authorMeredith, Fiona
dc.contributor.authorMuller, Frank
dc.contributor.authorNicolson, Marianne
dc.contributor.authorDahal, Lekh Nath
dc.contributor.authorAbu Eid, Rasha
dc.contributor.authorRajpara, Sanjay
dc.contributor.authorBarker, Robert Norman
dc.contributor.authorOrmerod, Anthony
dc.contributor.authorWard, Frank James
dc.date.accessioned2022-01-07T00:07:10Z
dc.date.available2022-01-07T00:07:10Z
dc.date.issued2022-01-05
dc.identifier.citationKhanolkar , R C , Zhang , C , al-Fatyan , F , Lawson , L G , Depasquale , I , Meredith , F , Muller , F , Nicolson , M , Dahal , L N , Abu Eid , R , Rajpara , S , Barker , R N , Ormerod , A & Ward , F J 2022 , ' TGFb2 induces the soluble isoform of CTLA-4 – implications for CTLA-4 based checkpoint inhibitor antibodies in malignant melanoma ' , Frontiers in Immunology , vol. 12 , 763877 . https://doi.org/10.3389/fimmu.2021.763877en
dc.identifier.issn1664-3224
dc.identifier.otherPURE: 210105818
dc.identifier.otherPURE UUID: d1266e03-83d2-4376-a11b-02bfd5b90d9c
dc.identifier.otherScopus: 85123167616
dc.identifier.urihttps://hdl.handle.net/2164/17798
dc.descriptionFUNDING This work was funded by the Chief Scientist’s office, Scotland grant no. ETM/280. Acknowledgments Microscopy was performed in the Microscopy and Histology Core Facility at the University of Aberdeen. Flow cytometry was performed in the Iain Fraser Cytometry Centre. We are very grateful to our lab manager Ms. Gill Moir for her assistance with this work and also to the many BSc/MSc project students who worked on this project. We are extremely grateful for all of the volunteer melanoma patient donors and healthy donors that supported this work. FA-F received an Elphinstone PhD scholarship funded by the School of Medicine, Medical Sciences & Nutrition at the University of Aberdeen.en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofFrontiers in Immunologyen
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.https://creativecommons.org/licenses/by/4.0/en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectcheckpoint inhibitoren
dc.subjectCTLA-4 (cytotoxic T lymphocyte-associated antigen 4)en
dc.subjectsCTLA-4en
dc.subjectmelanomaen
dc.subjectTGFb2en
dc.subjectT cellsen
dc.subjectR Medicineen
dc.subjectChief Scientist Office (CSO)en
dc.subjectETM/280en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleTGFb2 induces the soluble isoform of CTLA-4 – implications for CTLA-4 based checkpoint inhibitor antibodies in malignant melanomaen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Dental Educationen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Data Safe Havenen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.3389/fimmu.2021.763877
dc.identifier.vol12en


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