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Interleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Model

dc.contributor.authorBrice, Daniel P
dc.contributor.authorMurray, Graeme I.
dc.contributor.authorWilson, Heather M.
dc.contributor.authorPorter, Ross J.
dc.contributor.authorBerry, Susan
dc.contributor.authorDurum, Scott K.
dc.contributor.authorMcLean, Mairi H.
dc.date.accessioned2022-03-14T12:03:01Z
dc.date.available2022-03-14T12:03:01Z
dc.date.issued2022-03-11
dc.identifier.citationBrice , D P , Murray , G I , Wilson , H M , Porter , R J , Berry , S , Durum , S K & McLean , M H 2022 , ' Interleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Model ' , Biology , vol. 11 , no. 3 , 427 . https://doi.org/10.3390/biology11030427en
dc.identifier.issn2079-7737
dc.identifier.otherPURE: 214840970
dc.identifier.otherPURE UUID: f8386a1a-e419-4e52-b6e2-1360da8a4b6f
dc.identifier.otherBibtex: biology11030427
dc.identifier.otherORCID: /0000-0002-1407-7274/work/109934275
dc.identifier.otherORCID: /0000-0002-7443-2653/work/109934783
dc.identifier.otherScopus: 85126994453
dc.identifier.urihttps://hdl.handle.net/2164/18213
dc.descriptionFunding: This research was funded by CICRA (CICRA: better lives for children with crohns and colitis. Available online: https://www.cicra.org (last accessed on 23 January 2022); Ph.D. studentship to DBP) and an NHS Grampian Endowment project grant. Acknowledgments: We wish to acknowledge the Grampian Tissue Biorepository for assistance in tissue preparation. Organoids were stored at −80 ◦C at the University of Aberdeen. Graphical abstract was created using Biorender with a licence for use in publication (agreement number AD22YOD1N6). DBP now at Lydia Becker Institute of Immunology and Inflammation and Wellcome Centre for Cell-Matrix Research, University of Manchester, UKen
dc.format.extent16
dc.language.isoeng
dc.relation.ispartofBiologyen
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectIBDen
dc.subjectcolitisen
dc.subjectcytokineen
dc.subjectinterleukin-27en
dc.subjectepitheliumen
dc.subjectorganoiden
dc.subjectgastrointestinalen
dc.subjectpermeabilityen
dc.subjectR Medicineen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleInterleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Modelen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.3390/biology11030427
dc.identifier.vol11en
dc.identifier.iss3en


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