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Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects

dc.contributor.authorHendawy, O. M.
dc.contributor.authorGomaa, Hesham A.M.
dc.contributor.authorAlzarea, Sami I.
dc.contributor.authorAlshammari, Mutariah S.
dc.contributor.authorMohamed, Fatma A.M.
dc.contributor.authorMostafa, Yaser A.
dc.contributor.authorAbdelazeem, Ahmed H.
dc.contributor.authorAbdelrahman, Mostafa H.
dc.contributor.authorTrembleau, Laurent
dc.contributor.authorYoussif, Bahaa G.M.
dc.date.accessioned2022-08-23T23:07:22Z
dc.date.available2022-08-23T23:07:22Z
dc.date.issued2021-11-01
dc.identifier.citationHendawy , O M , Gomaa , H A M , Alzarea , S I , Alshammari , M S , Mohamed , F A M , Mostafa , Y A , Abdelazeem , A H , Abdelrahman , M H , Trembleau , L & Youssif , B G M 2021 , ' Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects ' , Bioorganic Chemistry , vol. 116 , 105302 . https://doi.org/10.1016/j.bioorg.2021.105302en
dc.identifier.issn0045-2068
dc.identifier.otherPURE: 200868606
dc.identifier.otherPURE UUID: 7d1c98a9-938b-46c0-8aa9-d6a2141d72f1
dc.identifier.otherScopus: 85113795824
dc.identifier.otherORCID: /0000-0001-6376-9077/work/100717603
dc.identifier.urihttps://hdl.handle.net/2164/19093
dc.descriptionFunding Information: The authors extend their appreciation to the Deanship of Scientific Research at Jouf University for funding this work through research grant number (DSR2020-04-421 )en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofBioorganic Chemistryen
dc.rightsthis manuscript is available under CC BY NC ND licence.https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectCardiomyopathyen
dc.subjectCOX-2/sEHen
dc.subjectNSAIDSen
dc.subjectPyrazolesen
dc.subjectQD Chemistryen
dc.subjectBiochemistryen
dc.subjectMolecular Biologyen
dc.subjectDrug Discoveryen
dc.subjectOrganic Chemistryen
dc.subjectSupplementary Dataen
dc.subjecthttps://doi. org/10.1016/j.bioorg.2021.105302en
dc.subject.lccQDen
dc.titleNovel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effectsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.description.statusPeer revieweden
dc.description.versionPostprinten
dc.identifier.doihttps://doi.org/10.1016/j.bioorg.2021.105302
dc.date.embargoedUntil2022-08-24
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85113795824&partnerID=8YFLogxKen
dc.identifier.vol116en


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