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pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis : a case series linking archival surgical biopsies with clinical phenotypic data

dc.contributor.authorPattle, Samuel B.
dc.contributor.authorO'shaughnessy, Judi
dc.contributor.authorKantelberg, Owen
dc.contributor.authorRifai, Olivia M
dc.contributor.authorPate, Judith
dc.contributor.authorNellany, Kristine
dc.contributor.authorHays, Nadine
dc.contributor.authorArends, Mark J.
dc.contributor.authorHorrocks, Mathew
dc.contributor.authorWaldron, Fergal M
dc.contributor.authorGregory, Jenna
dc.date.accessioned2022-09-28T11:11:01Z
dc.date.available2022-09-28T11:11:01Z
dc.date.issued2023-01
dc.identifier.citationPattle , S B , O'shaughnessy , J , Kantelberg , O , Rifai , O M , Pate , J , Nellany , K , Hays , N , Arends , M J , Horrocks , M , Waldron , F M & Gregory , J 2023 , ' pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis : a case series linking archival surgical biopsies with clinical phenotypic data ' , Journal of Pathology: Clinical Research , vol. 9 , no. 1 , pp. 44-55 . https://doi.org/10.1002/cjp2.297en
dc.identifier.issn2056-4538
dc.identifier.otherPURE: 219632653
dc.identifier.otherPURE UUID: 4bda130a-0f76-4c79-80a6-7255ec37d627
dc.identifier.otherORCID: /0000-0003-3337-4079/work/121060124
dc.identifier.otherScopus: 85139604897
dc.identifier.otherORCID: /0000-0003-2622-0776/work/122445594
dc.identifier.otherWOS: 000866526100001
dc.identifier.urihttps://hdl.handle.net/2164/19245
dc.descriptionAcknowledgements The authors would like to thank the staff at the NHS Lothian BioResource (Vishad Patel and Craig Marshall) and the NHS Grampian biorepository (Joan Wilson) and the staff and corefunded resources of the imaging and histology core facility at the Institute of Medical Sciences (Gillian Milne, Lucinda Wight, and Debbie Wilkinson). This study was funded by the Pathological Society/Jean Shanks Foundation (JSPS CLSG 202002 to JMG and JO’S), The Royal Society (RGS\R1\221396 to JMG) and the Wellcome Trust (108890/Z/15/Z to OR). Funders had no role in study design, data collection, data analyses, interpretation, or writing the manuscripten
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofJournal of Pathology: Clinical Researchen
dc.rights2022 The Authors. The Journal of Pathology: Clinical Research published by The Pathological Society of Great Britain and Ireland and John Wiley &Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectALSen
dc.subjectTDP-43en
dc.subjectGastrointestinal tracten
dc.subjectNon-CNS tissueen
dc.subjecthuman tissueen
dc.subjectpathologyen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subject108890/Z/15/Zen
dc.subjectOtheren
dc.subjectRGS\R1\221396en
dc.subjectJSPS CLSG 202002en
dc.subject.lccRen
dc.titlepTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis : a case series linking archival surgical biopsies with clinical phenotypic dataen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1002/cjp2.297
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85139604897&partnerID=8YFLogxKen
dc.identifier.vol9en
dc.identifier.iss1en


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