Show simple item record

Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

dc.contributor.authorHigham, Jonathan
dc.contributor.authorKerr, Lyndsay
dc.contributor.authorZhang, Qian
dc.contributor.authorWalker, Rosie M
dc.contributor.authorHarris, Sarah E
dc.contributor.authorHoward, David M
dc.contributor.authorHawkins, Emma L
dc.contributor.authorSandu, Anca-Larisa
dc.contributor.authorSteele, J Douglas
dc.contributor.authorWaiter, Gordon D
dc.contributor.authorMurray, Alison D
dc.contributor.authorEvans, Kathryn L
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorVisscher, Peter M
dc.contributor.authorDeary, Ian J
dc.contributor.authorCox, Simon R
dc.contributor.authorSproul, Duncan
dc.date.accessioned2022-10-19T14:07:01Z
dc.date.available2022-10-19T14:07:01Z
dc.date.issued2022-10-17
dc.identifier.citationHigham , J , Kerr , L , Zhang , Q , Walker , R M , Harris , S E , Howard , D M , Hawkins , E L , Sandu , A-L , Steele , J D , Waiter , G D , Murray , A D , Evans , K L , McIntosh , A M , Visscher , P M , Deary , I J , Cox , S R & Sproul , D 2022 , ' Local CpG density affects the trajectory and variance of age-associated DNA methylation changes ' , Genome Biology , vol. 23 , no. 1 , 216 . https://doi.org/10.1186/s13059-022-02787-8en
dc.identifier.issn1474-760X
dc.identifier.otherPURE: 220071852
dc.identifier.otherPURE UUID: 06140561-ec17-44a1-8fdc-1a698def2ff8
dc.identifier.otherPubMed: 36253871
dc.identifier.otherORCID: /0000-0002-5555-4129/work/121536111
dc.identifier.otherORCID: /0000-0002-5313-9845/work/121540264
dc.identifier.otherScopus: 85139819868
dc.identifier.urihttps://hdl.handle.net/2164/19407
dc.descriptionAcknowledgements We thank Riccardo Marioni, Chris Haley, Ailith Ewing, David Porteous, Chris Ponting, Rob Illingworth, Tamir Chandra, Sara Hagg, Yunzhang Wang, Chantriolnt-Andreas Kapourani, Nick Gilbert, Hannes Becher and members of the Sproul lab for helpful discussions about the study and the manuscript. This work has made use of the resources provided by the University of Edinburgh digital research services and the MRC IGC compute cluster. We are grateful to all the families who took part in the Generation Scotland study along with the general practitioners and the Scottish School of Primary Care for their help in recruiting them, and the entire Generation Scotland team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, healthcare assistants, and nurses. Peer review information Anahita Bishop and Kevin Pang were the primary editors of this article and managed its editorial process and peer review in collaboration with the rest of the editorial team. Review history The review history is available as Additional file 3. Funding DS is a Cancer Research UK Career Development fellow (reference C47648/A20837), and work in his laboratory is also supported by an MRC university grant to the MRC Human Genetics Unit. LK is a cross-disciplinary postdoctoral fellow supported by funding from the University of Edinburgh and Medical Research Council (MC_UU_00009/2). S.R.C. and I.J.D. were supported by a National Institutes of Health (NIH) research grant R01AG054628, and S.R.C is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (221890/Z/20/Z). AMM is supported by the Wellcome Trust (104036/Z/14/Z, 216767/Z/19/Z, 220857/Z/20/Z) and UKRI MRC (MC_PC_17209, MR/S035818/1). PMV acknowledges support from the Australian National Health and Medical Research Council (1113400) and the Australian Research Council (FL180100072). DMH is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Reference 213674/Z/18/Z). We thank the LBC1936 participants and team members who contributed to the study. Further study information can be found at https://www.ed.ac.uk/lothian-birth-cohorts. The LBC1936 is supported by a jointly funded grant from the BBSRC and ESRC (BB/W008793/1), and also by Age UK (Disconnected Mind project), the Medical Research Council (G0701120, G1001245, MR/M013111/1, MR/R024065/1), and the University of Edinburgh. Genotyping of LBC1936 was funded by the BBSRC (BB/F019394/1), and methylation typing of LBC1936 was supported by Centre for Cognitive Ageing and Cognitive Epidemiology (Pilot Fund award), Age UK, The Wellcome Trust Institutional Strategic Support Fund, The University of Edinburgh, and The University of Queensland. Work on Generation Scotland was supported by a Wellcome Strategic Award “STratifying Resilience and Depression Longitudinally” (STRADL; 104036/Z/14/Z) to AMM, KLE, and others, and an MRC Mental Health Data Pathfinder Grant (MC_PC_17209) to AMM. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). DNA methylation profiling and analysis of the GS:SFHS samples was supported by Wellcome Investigator Award 220857/Z/20/Z and Grant 104036/Z/14/Z (PI: AM McIntosh) and through funding from NARSAD (Ref: 27404; awardee: Dr DM Howard) and the Royal College of Physicians of Edinburgh (Sim Fellowship; Awardee: Dr HC Whalley).en
dc.format.extent28
dc.language.isoeng
dc.relation.ispartofGenome Biologyen
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicineen
dc.subjectCancer Research UKen
dc.subjectC47648/A20837en
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_UU_00009/2en
dc.subjectMC_PC_17209en
dc.subjectMR/S035818/1en
dc.subjectG0701120en
dc.subjectG1001245en
dc.subjectMR/M013111/1en
dc.subjectWellcome Trusten
dc.subject221890/Z/20/Zen
dc.subject104036/Z/14/Zen
dc.subject216767/Z/19/Zen
dc.subject220857/Z/20/Zen
dc.subjectMR/R024065/1en
dc.subjectEconomic and Social Research Council (ESRC)en
dc.subjectBB/W008793/1en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/W008793/1en
dc.subjectBB/F019394/1)en
dc.subjectChief Scientist Office (CSO)en
dc.subjectCZD/16/6en
dc.subjectOtheren
dc.subjectHR03006en
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleLocal CpG density affects the trajectory and variance of age-associated DNA methylation changesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1186/s13059-022-02787-8
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85139819868&partnerID=8YFLogxKen
dc.identifier.vol23en
dc.identifier.iss1en


Files in this item

Thumbnail
Name:
Higham_etal_GB_Local_GP_Densit ...
Size:
34.59Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record