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Reactivation of epigenetically silenced miR-124 reverses the epithelial-to-mesenchymal transition and inhibits invasion in endometrial cancer cells via the direct repression of IQGAP1 expression.

dc.contributor.authorDong, Peixin
dc.contributor.authorIhira, Kei
dc.contributor.authorXiong, Ying
dc.contributor.authorWatari, Hidemichi
dc.contributor.authorHanley, Sharon J. B.
dc.contributor.authorYamada, Takahiro
dc.contributor.authorHosaka, Masayoshi
dc.contributor.authorKudo, Masataka
dc.contributor.authorYue, Junming
dc.contributor.authorSakuragi, Noriaki
dc.date.accessioned2023-02-03T16:23:01Z
dc.date.available2023-02-03T16:23:01Z
dc.date.issued2016-02-26
dc.identifier.citationDong , P , Ihira , K , Xiong , Y , Watari , H , Hanley , S J B , Yamada , T , Hosaka , M , Kudo , M , Yue , J & Sakuragi , N 2016 , ' Reactivation of epigenetically silenced miR-124 reverses the epithelial-to-mesenchymal transition and inhibits invasion in endometrial cancer cells via the direct repression of IQGAP1 expression. ' , Oncotarget , vol. 7 , no. 15 , pp. 20260-20270 . https://doi.org/10.18632/oncotarget.7754en
dc.identifier.issn1949-2553
dc.identifier.otherPURE: 226328848
dc.identifier.otherPURE UUID: 162b4088-ac88-4805-8d1e-16fcd86a296a
dc.identifier.otherRIS: urn:05E34CF4063E0B4D0DB2F8387B052D54
dc.identifier.otherORCID: /0000-0002-7554-004X/work/127304271
dc.identifier.otherScopus: 84964797413
dc.identifier.urihttps://hdl.handle.net/2164/19975
dc.descriptionACKNOWLEDGMENTS: We thank Professor Kozo Kaibuchi for providing plasmids (pEGFR-IQGAP1-WT and pEGFR empty vector) and Dr. Zhujie Xu for technical assistance. The authors wish to thank Dr. Victor Manuel Treviño Alvarado (Tecnológico de Monterrey, Campus Monterrey) for his constructive comments. CONFLICTS INTERESTS: The authors declare no conflicts of interest. GRANT SUPPORT: This work was funded by a grant from the Department of Women’s Health Educational System, a Grant-in-Aid for Scientific Research (C) (15K10697) and Science and Technology Planning Project of Guangdong Province, China (2013B021800155).en
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofOncotargeten
dc.rightsAll site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License. https://creativecommons.org/licenses/by/3.0/en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectNeoplasm Invasivenessen
dc.subjectMicroRNAs/*geneticsen
dc.subjectTumor Cells, Cultureden
dc.subjectCell Movementen
dc.subjectCell Proliferationen
dc.subjectPrognosisen
dc.subject*Epigenomicsen
dc.subject*Gene Expression Regulation, Neoplasticen
dc.subjectApoptosisen
dc.subjectBiomarkers, Tumor/geneticsen
dc.subjectDNA Methylationen
dc.subjectDNA methyltransferase inhibitoren
dc.subjectendometrial cancer cell invasionen
dc.subjectEndometrial Neoplasms/*genetics/*pathologyen
dc.subjectepigeneticsen
dc.subjectEpithelial-Mesenchymal Transitionen
dc.subjectIQGAP1en
dc.subjectmiR-124en
dc.subjectras GTPase-Activating Proteins/genetics/*metabolismen
dc.subjectSurvival Rateen
dc.titleReactivation of epigenetically silenced miR-124 reverses the epithelial-to-mesenchymal transition and inhibits invasion in endometrial cancer cells via the direct repression of IQGAP1 expression.en
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.18632/oncotarget.7754
dc.identifier.vol7en
dc.identifier.iss15en


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