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Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial

dc.contributor.authorDawson, Jesse
dc.contributor.authorRobertson, Michele
dc.contributor.authorDickie, David Alexander
dc.contributor.authorBath, Phillip
dc.contributor.authorForbes, Kirsten
dc.contributor.authorQuinn, Terence
dc.contributor.authorBroomfield, Niall M.
dc.contributor.authorDani, Krishna
dc.contributor.authorDoney, Alex
dc.contributor.authorHouston, Graeme
dc.contributor.authorLees, Kennedy R.
dc.contributor.authorMuir, Keith W.
dc.contributor.authorStruthers, Allan
dc.contributor.authorWalters, Matthew
dc.contributor.authorBarber, Mark
dc.contributor.authorBhalla, Ajay
dc.contributor.authorCameron, Alan
dc.contributor.authorDyker, Alexander
dc.contributor.authorGuyler, Paul
dc.contributor.authorHassan, Ahamad
dc.contributor.authorKearney, Mark T.
dc.contributor.authorKeegan, Breffni
dc.contributor.authorLakshmanan, Sekaran
dc.contributor.authorMacleod, Mary Joan
dc.contributor.authorRandall, Marc
dc.contributor.authorShaw, Louise
dc.contributor.authorSubramanian, Ganesh
dc.contributor.authorWerring, David
dc.contributor.authorMcConnachie, Alex
dc.date.accessioned2023-02-20T11:34:01Z
dc.date.available2023-02-20T11:34:01Z
dc.date.issued2023-03-01
dc.identifier.citationDawson , J , Robertson , M , Dickie , D A , Bath , P , Forbes , K , Quinn , T , Broomfield , N M , Dani , K , Doney , A , Houston , G , Lees , K R , Muir , K W , Struthers , A , Walters , M , Barber , M , Bhalla , A , Cameron , A , Dyker , A , Guyler , P , Hassan , A , Kearney , M T , Keegan , B , Lakshmanan , S , Macleod , M J , Randall , M , Shaw , L , Subramanian , G , Werring , D & McConnachie , A 2023 , ' Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial ' , EClinicalMedicine , vol. 57 , 101863 . https://doi.org/10.1016/j.eclinm.2023.101863en
dc.identifier.issn2589-5370
dc.identifier.otherPURE: 228431119
dc.identifier.otherPURE UUID: efdc5163-d982-456a-8146-bcb6521bc353
dc.identifier.otherRIS: urn:F198F7588192254F912BD60537171CE7
dc.identifier.otherORCID: /0000-0003-2115-8184/work/129409185
dc.identifier.otherScopus: 85148380352
dc.identifier.otherPubMed: 36864979
dc.identifier.urihttps://hdl.handle.net/2164/20110
dc.descriptionAcknowledgments This work was supported by the Stroke Association and British Heart Foundation [grant number TSA BHF 2013/01]. The work of Dr David Dickie and Dr Terry Quinn is funded by the Stroke Association. We would like to thank Christine McAlpine, Ruth Graham, Glasgow Royal Infirmary, UK; Lauren Pearce, Royal United Hospital, UK; Caroline Fornolles, Louise Tate, Frances Justin, Luton and Dunstable University Hospital, UK; Dean Waugh, Leeds Teaching Hospitals NHS Trust, UK; Donal Concannon, Altnagelvin Hospital, UK; Sharon Tysoe, Nina Francia, Nisha Menon, Raji Prabakaran, Southend University Hospital, UK; Amy Ashton, Caroline Watchurst, Marilena Marinescu, Sabaa Obarey, Scheherazade Feerick, University College London NHS Foundation Trust, UK; and Janice Irvine, Sandra Williams, and German Guzman Gutierrez, Aberdeen Royal Infirmary, UK; Caroline Fox and Joanne Topliffe, Broomfield Hospital, Essex, UK.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofEClinicalMedicineen
dc.rightsCopyright © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectStrokeen
dc.subjectAllopurinolen
dc.subjectHypertensionen
dc.subjectWhite matter hyperintensitiesen
dc.subjectR Medicineen
dc.subjectBritish Heart Foundationen
dc.subjectTSA BHF 2013/01en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleXanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trialen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Centre for Health Data Scienceen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1016/j.eclinm.2023.101863
dc.identifier.vol57en


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