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Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population

dc.contributor.authorClarke, T-K
dc.contributor.authorLupton, M. K.
dc.contributor.authorFernandez-Pujals, A. M.
dc.contributor.authorStarr, J.
dc.contributor.authorDavies, G.
dc.contributor.authorCox, S.
dc.contributor.authorPattie, A.
dc.contributor.authorLiewald, D. C.
dc.contributor.authorHall, L. S.
dc.contributor.authorMacIntyre, D. J.
dc.contributor.authorSmith, B. H.
dc.contributor.authorHocking, L. J.
dc.contributor.authorPadmanabhan, S.
dc.contributor.authorThomson, P. A.
dc.contributor.authorHayward, C.
dc.contributor.authorHansell, N. K.
dc.contributor.authorMontgomery, G. W.
dc.contributor.authorMedland, S. E.
dc.contributor.authorMartin, N. G.
dc.contributor.authorWright, M. J.
dc.contributor.authorPorteous, D. J.
dc.contributor.authorDeary, I. J.
dc.contributor.authorMcIntosh, A. M.
dc.date.accessioned2016-03-28T16:00:11Z
dc.date.available2016-03-28T16:00:11Z
dc.date.issued2016-03
dc.identifier.citationClarke , T-K , Lupton , M K , Fernandez-Pujals , A M , Starr , J , Davies , G , Cox , S , Pattie , A , Liewald , D C , Hall , L S , MacIntyre , D J , Smith , B H , Hocking , L J , Padmanabhan , S , Thomson , P A , Hayward , C , Hansell , N K , Montgomery , G W , Medland , S E , Martin , N G , Wright , M J , Porteous , D J , Deary , I J & McIntosh , A M 2016 , ' Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population ' , Molecular Psychiatry , vol. 21 , no. 3 , pp. 419-425 . https://doi.org/10.1038/mp.2015.12en
dc.identifier.issn1359-4184
dc.identifier.otherPURE: 64326572
dc.identifier.otherPURE UUID: 110cb993-4fa6-40ce-9c84-a15d60fce3b9
dc.identifier.otherWOS: 000370820900015
dc.identifier.otherScopus: 84958882630
dc.identifier.urihttp://hdl.handle.net/2164/5770
dc.descriptionAcknowledgements Generation Scotland has received core funding from the Chief Scientist Office of the Scottish Government Health Directorates CZD/16/6 and the Scottish Funding Council HR03006. We are grateful to all the families who took part, the general practitioners and the Scottish School of Primary Care for their help in recruiting them and the whole Generation Scotland team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, health-care assistants and nurses. We acknowledge with gratitude the financial support received for this work from the Dr Mortimer and Theresa Sackler Foundation. For the Lothian Birth Cohorts (LBC1921 and LBC1936), we thank Paul Redmond for database management assistance; Alan Gow, Martha Whiteman, Alison Pattie, Michelle Taylor, Janie Corley, Caroline Brett and Caroline Cameron for data collection and data entry; nurses and staff at the Wellcome Trust Clinical Research Facility, where blood extraction and genotyping was performed; staff at the Lothian Health Board; and the staff at the SCRE Centre, University of Glasgow. The research was supported by a program grant from Age UK (Disconnected Mind) and by grants from the Biotechnology and Biological Sciences Research Council (BBSRC). The work was undertaken by The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1). Funding from the Medical Research Council (MRC) and BBSRC is gratefully acknowledged. DJM is an NRS Career Research Fellow funded by the CSO. BATS were funded by the Australian Research Council (A79600334, A79906588, A79801419, DP0212016, DP0664638, and DP1093900) and the National Health and Medical Research Council (389875) Australia. MKL is supported by a Perpetual Foundation Wilson Fellowship. SEM is supported by a Future Fellowship (FT110100548) from the Australian Research Council. GWM is supported by a National Health and Medical Research Council (NHMRC), Australia, Fellowship (619667). We thank the twins and siblings for their participation, Marlene Grace, Ann Eldridge and Natalie Garden for cognitive assessments, Kerrie McAloney, Daniel Park, David Smyth and Harry Beeby for research support, Anjali Henders and staff in the Molecular Epidemiology Laboratory for DNA sample processing and preparation and Scott Gordon for quality control and management of the genotypes. This work is supported by a Stragetic Award from the Wellcome Trust, reference 104036/Z/14/Z.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofMolecular Psychiatryen
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if thematerial is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectChief Scientist Office (CSO)en
dc.subjectCZD/16/6en
dc.subjectMedical Research Council (MRC)en
dc.subject619667en
dc.subject389875en
dc.subjectScottish Funding Councilen
dc.subjectHR03006en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subject.lccRC0321en
dc.titleCommon polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general populationen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Life Sciences & Medicineen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1038/mp.2015.12
dc.identifier.vol21en
dc.identifier.iss3en


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